Abnormal T Cell Frequencies, Including Cytomegalovirus-Associated Expansions, Distinguish Seroconverted Subjects at Risk for Type 1 Diabetes

Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes

(2018) Lorraine Yeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity

(2018) John B. Harley et al.   NATURE GENETICS

MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A

(2018) Lauren J. Howson et al.   Nature Communications

Pre-diagnostic genotyping identifies T1D subjects with impaired Treg IL-2 signaling and an elevated proportion of FOXP3+IL-17+ cells

(2017) A K Marwaha et al.   GENES AND IMMUNITY

Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection

(2017) Nicola L. Harris et al.   IMMUNITY

Duodenal Mucosa of Patients With Type 1 Diabetes Shows Distinctive Inflammatory Profile and Microbiota

(2017) Silvia Pellegrini et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Autoreactive T cells in type 1 diabetes

(2017) Alberto Pugliese   JOURNAL OF CLINICAL INVESTIGATION

Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002–2012

(2017) Elizabeth J. Mayer-Davis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines

(2017) Joana Dias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin (IL)-18 Binding Protein Deficiency Disrupts Natural Killer Cell Maturation and Diminishes Circulating IL-18

(2017) Robert Z. Harms et al.   Frontiers in Immunology

Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis

(2017) Chunguang Chen et al.   Molecular Metabolism

MAIT cells are reduced in frequency and functionally impaired in human T lymphotropic virus type 1 infection: Potential clinical implications

(2017) Dominic Paquin-Proulx et al.   PLoS One

Life and death of β cells in Type 1 diabetes: A comprehensive review

(2016) Nicholas S. Wilcox et al.   JOURNAL OF AUTOIMMUNITY

Environmental risk factors for type 1 diabetes

(2016) Marian Rewers et al.   LANCET

Genetic risk factors for type 1 diabetes

(2016) Flemming Pociot et al.   LANCET

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18–dependent activation

(2016) Liyen Loh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of the Phenotype and Function of the Subpopulations of Mucosal-Associated Invariant T Cells

(2016) J. Brozova et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

MAIT cells are activated during human viral infections

(2016) Bonnie van Wilgenburg et al.   Nature Communications

The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes

(2015) Aleksandar D. Kostic et al.   Cell Host & Microbe

The implications of autoantibodies to a single islet antigen in relatives with normal glucose tolerance: development of other autoantibodies and progression to type 1 diabetes

(2015) Polly J. Bingley et al.   DIABETOLOGIA

Reduced Numbers and Proapoptotic Features of Mucosal-associated Invariant T Cells as a Characteristic Finding in Patients with Inflammatory Bowel Disease

(2015) Eitaro Hiejima et al.   INFLAMMATORY BOWEL DISEASES

HIV-specific CD8+ T cell mediated viral suppression correlates with the expression of CD57

(2015) Sanne Skov Jensen et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells

(2015) Sidonia B. G. Eckle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β Cell death and dysfunction during type 1 diabetes development in at-risk individuals

(2015) Kevan C. Herold et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered CD161bright CD8+ Mucosal Associated Invariant T (MAIT)-Like Cell Dynamics and Increased Differentiation States among Juvenile Type 1 Diabetics

(2015) Robert Z. Harms et al.   PLoS One

Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes

(2014) Lars Krogvold et al.   DIABETES

A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

(2014) R. C. Ferreira et al.   DIABETES

Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study

(2014) Lars Krogvold et al.   DIABETOLOGIA

CD8+MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL-18 serum levels in multiple sclerosis

(2014) Anne Willing et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mucosal-Associated Invariant T Cell Deficiency in Systemic Lupus Erythematosus

(2014) Young-Nan Cho et al.   JOURNAL OF IMMUNOLOGY

Enteric Mucosa Integrity in the Presence of a Preserved Innate Interleukin 22 Compartment in HIV Type 1–Treated Individuals

(2014) Susana M. Fernandes et al.   JOURNAL OF INFECTIOUS DISEASES

MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets

(2014) A Kurioka et al.   Mucosal Immunology

Impact of HIV on CD8+ T Cell CD57 Expression Is Distinct from That of CMV and Aging

(2014) Sulggi A. Lee et al.   PLoS One

Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development

(2014) Edwin Leeansyah et al.   Nature Communications

The who's who of T-cell differentiation: Human memory T-cell subsets

(2013) Yolanda D. Mahnke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

(2013) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Probability state modeling of memory CD8+ T-cell differentiation

(2013) Margaret S. Inokuma et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

Persistent Changes in Circulating and Intestinal γδ T Cell Subsets, Invariant Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Children and Adults with Coeliac Disease

(2013) Margaret R. Dunne et al.   PLoS One

Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans

(2013) D. Sugiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAIT Cells Detect and Efficiently Lyse Bacterially-Infected Epithelial Cells

(2013) Lionel Le Bourhis et al.   PLoS Pathogens

Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection

(2012) E. Leeansyah et al.   BLOOD

Early and nonreversible decrease of CD161++/MAIT cells in HIV infection

(2012) C. Cosgrove et al.   BLOOD

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis

(2012) C J Kim et al.   Mucosal Immunology

Hygiene Hypothesis and Autoimmune Diseases

(2011) Graham A. W. Rook   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Expression and Regulation of Chemokines in Murine and Human Type 1 Diabetes

(2011) S. A. Sarkar et al.   DIABETES

Age of Islet Autoantibody Appearance and Mean Levels of Insulin, but Not GAD or IA-2 Autoantibodies, Predict Age of Diagnosis of Type 1 Diabetes: Diabetes Autoimmunity Study in the Young

(2011) A. K. Steck et al.   DIABETES CARE

Development of Autoantibodies in the TrialNet Natural History Study

(2011) K. Vehik et al.   DIABETES CARE

CD8+ T Cells: Foot Soldiers of the Immune System

(2011) Nu Zhang et al.   IMMUNITY

Susceptibility of Human Pancreatic β Cells for Cytomegalovirus Infection and the Effects on Cellular Immunogenicity

(2011) Maaike J. Smelt et al.   PANCREAS

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Changes in histone acetylation and methylation that are important for persistent but not transient expression of CCR4 in human CD4+ T cells

(2010) Satya P. Singh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Proliferation Capacity and Cytotoxic Activity Are Mediated by Functionally and Phenotypically Distinct Virus-Specific CD8 T Cells Defined by Interleukin-7R  (CD127) and Perforin Expression

(2010) C. Cellerai et al.   JOURNAL OF VIROLOGY

Immunotherapy for the Prevention and Treatment of Type 1 Diabetes: Human trials and a look into the future

(2009) M. Rewers et al.   DIABETES CARE

CD127low/- and FoxP3+ Expression Levels Characterize Different Regulatory T-Cell Populations in Human Peripheral Blood

(2009) Sandra Klein et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

Stepwise Development of MAIT Cells in Mouse and Human

(2009) Emmanuel Martin et al.   PLOS BIOLOGY

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes

(2008) A. L. Putnam et al.   DIABETES

CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

(2008) Ania Skowera et al.   JOURNAL OF CLINICAL INVESTIGATION

Human cytomegalovirus: Latency and reactivation in the myeloid lineage

(2008) John Sinclair   JOURNAL OF CLINICAL VIROLOGY

The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression

(2008) P. K. Chattopadhyay et al.   JOURNAL OF LEUKOCYTE BIOLOGY