Pre-diagnostic genotyping identifies T1D subjects with impaired Treg IL-2 signaling and an elevated proportion of FOXP3+IL-17+ cells
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Title
Pre-diagnostic genotyping identifies T1D subjects with impaired Treg IL-2 signaling and an elevated proportion of FOXP3+IL-17+ cells
Authors
Keywords
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Journal
GENES AND IMMUNITY
Volume 18, Issue 1, Pages 15-21
Publisher
Springer Nature
Online
2017-01-05
DOI
10.1038/gene.2016.44
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Note: Only part of the references are listed.- Targeting the IL-17/IFN-γ axis as a potential new clinical therapy for type 1 diabetes
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- Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial
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- CD4+FOXP3+ T Regulatory Cells in Human Autoimmunity: More Than a Numbers Game
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- Cutting Edge: Increased IL-17-Secreting T Cells in Children with New-Onset Type 1 Diabetes
- (2010) A. K. Marwaha et al. JOURNAL OF IMMUNOLOGY
- Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects
- (2009) S. A. Long et al. DIABETES
- The type I diabetes association of the IL2RA locus
- (2009) H-Q Qu et al. GENES AND IMMUNITY
- Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor
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- A cis-Acting Regulatory Variant in the IL2RA Locus
- (2009) H.-Q. Qu et al. JOURNAL OF IMMUNOLOGY
- Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
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- IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production
- (2009) Lisa M. Maier et al. PLoS Genetics
- A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3
- (2008) P. Concannon et al. DIABETES
- Genetic Association between the Interleukin-2 Receptor-α Gene and Mode of Onset of Type 1 Diabetes in the Japanese Population
- (2008) Eiji Kawasaki et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- The TrialNet Natural History Study of the Development of Type 1 Diabetes: objectives, design, and initial results
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