The principal pathways involved in thein vivomodulation of hypoxic pulmonary vasoconstriction, pulmonary arterial remodelling and pulmonary hypertension

2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension

(2015) Nazzareno Galiè et al.   EUROPEAN HEART JOURNAL

Exaggerated Hypoxic Pulmonary Vasoconstriction Without Susceptibility to High Altitude Pulmonary Edema

(2015) Christoph Dehnert et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Sarpogrelate hydrochloride, a serotonin 5HT2A receptor antagonist, ameliorates the development of chronic hypoxic pulmonary hypertension in rats

(2015) Erquan Zhang et al.   Journal of Anesthesia

Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice

(2015) Michael Seimetz et al.   PLoS One

Bosentan in Pulmonary Hypertension Associated with Fibrotic Idiopathic Interstitial Pneumonia

(2014) Tamera J. Corte et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Stimulation of Soluble Guanylate Cyclase Prevents Cigarette Smoke–induced Pulmonary Hypertension and Emphysema

(2014) Norbert Weissmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

P2Y1 and P2Y12 receptors in hypoxia- and adenosine diphosphate-induced pulmonary vasoconstriction in vivo in the pig

(2014) David Kylhammar et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Regulation of the skeletal muscle blood flow in humans

(2014) Stefan P. Mortensen et al.   EXPERIMENTAL PHYSIOLOGY

Tadalafil in patients with chronic obstructive pulmonary disease: a randomised, double-blind, parallel-group, placebo-controlled trial

(2014) Andrew R Goudie et al.   Lancet Respiratory Medicine

Sildenafil to improve respiratory rehabilitation outcomes in COPD: a controlled trial

(2013) Isabel Blanco et al.   EUROPEAN RESPIRATORY JOURNAL

Pulmonary hypertension and the right ventricle in hypoxia

(2013) Robert Naeije et al.   EXPERIMENTAL PHYSIOLOGY

Pulmonary Hypertension in Chronic Lung Diseases

(2013) Werner Seeger et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

sGC stimulation totally reverses hypoxia-induced pulmonary vasoconstriction alone and combined with dual endothelin-receptor blockade in a porcine model

(2012) J. Lundgren et al.   Acta Physiologica

Cyclooxygenase-2 inhibition and thromboxane A2 receptor antagonism attenuate hypoxic pulmonary vasoconstriction in a porcine model

(2012) D. Kylhammar et al.   Acta Physiologica

Efficacy of tadalafil in chronic hypobaric hypoxia-induced pulmonary hypertension: possible mechanisms

(2012) Masrat Rashid et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Mechanisms of pulmonary hypertension in chronic obstructive pulmonary disease: A pathophysiologic review

(2012) Jeremy P. Wrobel et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Prevalence, predictors, and survival in pulmonary hypertension related to end-stage chronic obstructive pulmonary disease

(2012) Kasper Hasseriis Andersen et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Pulmonary arterial lesions in explanted lungs after transplantation correlate with severity of pulmonary hypertension in chronic obstructive pulmonary disease

(2012) Jørn Carlsen et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Hypoxic Pulmonary Vasoconstriction

(2012) J. T. Sylvester et al.   PHYSIOLOGICAL REVIEWS

Pulmonary Hypertension as a Prognostic Indicator at the Initial Evaluation in Idiopathic Pulmonary Fibrosis

(2012) Motohiro Kimura et al.   RESPIRATION

Furegrelate, a Thromboxane Synthase Inhibitor, Blunts the Development of Pulmonary Arterial Hypertension in Neonatal Piglets

(2012) Dinesh K. Hirenallur-S et al.   Pulmonary Circulation

Bosentan Effects in Hypoxic Pulmonary Vasoconstriction: Preliminary Study in Subjects with or without High Altitude Pulmonary Edema-History

(2012) Isabelle Pham et al.   Pulmonary Circulation

Dual endothelin receptor blockade with tezosentan markedly attenuates hypoxia-induced pulmonary vasoconstriction in a porcine model

(2011) P. Hedelin et al.   Acta Physiologica

Endothelium-mediated control of vascular tone: COX-1 and COX-2 products

(2011) Michel Félétou et al.   BRITISH JOURNAL OF PHARMACOLOGY

Analysis of responses to the Rho-kinase inhibitor Y-27632 in the pulmonary and systemic vascular bed of the rat

(2010) David B. Casey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelin receptors blockade blunts hypoxia-induced increase in PAP in humans

(2010) I. Pham et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

BAY 41-2272 inhibits the development of chronic hypoxic pulmonary hypertension in rats

(2010) Lise Bech Thorsen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Treprostinil inhibits the recruitment of bone marrow-derived circulating fibrocytes in chronic hypoxic pulmonary hypertension

(2010) V. S. Nikam et al.   EUROPEAN RESPIRATORY JOURNAL

Pulmonary artery pressure limits exercise capacity at high altitude

(2010) R. Naeije et al.   EUROPEAN RESPIRATORY JOURNAL

Effects of inhaled nitric oxide at rest and during exercise in idiopathic pulmonary fibrosis

(2010) Isabel Blanco et al.   JOURNAL OF APPLIED PHYSIOLOGY

Regulation of the Pulmonary Circulation in the Fetus and Newborn

(2010) Yuansheng Gao et al.   PHYSIOLOGICAL REVIEWS

New Insights in the Pathogenesis of High-Altitude Pulmonary Edema

(2010) Urs Scherrer et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Effects of hypercapnia with and without acidosis on hypoxic pulmonary vasoconstriction

(2009) Farzaneh Ketabchi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Dexamethasone But Not Tadalafil Improves Exercise Capacity in Adults Prone to High-Altitude Pulmonary Edema

(2009) Manuel Fischler et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hemodynamic and Gas Exchange Effects of Sildenafil in Patients with Chronic Obstructive Pulmonary Disease and Pulmonary Hypertension

(2009) Isabel Blanco et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bosentan Decreases Pulmonary Vascular Resistance and Improves Exercise Capacity in Acute Hypoxia

(2009) Vitalie Faoro et al.   CHEST

First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension

(2009) F. Grimminger et al.   EUROPEAN RESPIRATORY JOURNAL

Ventilation-perfusion imbalance and chronic obstructive pulmonary disease staging severity

(2009) Roberto Rodríguez-Roisin et al.   JOURNAL OF APPLIED PHYSIOLOGY

Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat

(2008) Adeleke M. Badejo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Plasma Pro-Adrenomedullin But Not Plasma Pro-Endothelin Predicts Survival in Exacerbations of COPD

(2008) Daiana Stolz et al.   CHEST

Absence of Cyclooxygenase-2 Exacerbates Hypoxia-Induced Pulmonary Hypertension and Enhances Contractility of Vascular Smooth Muscle Cells

(2008) Laura E. Fredenburgh et al.   CIRCULATION

Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension

(2008) R. T. Schermuly et al.   EUROPEAN RESPIRATORY JOURNAL

A randomised, controlled trial of bosentan in severe COPD

(2008) D. Stolz et al.   EUROPEAN RESPIRATORY JOURNAL

Intravenous Tezosentan and Vardenafil Attenuate Acute Hypoxic Pulmonary Hypertension

(2008) Ralf Geiger et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Sildenafil Acutely Reverses the Hypoxic Pulmonary Vasoconstriction Response of the Newborn Pig

(2008) Rogerio Tessler et al.   PEDIATRIC RESEARCH

Luminal ATP-induced contraction of rabbit pulmonary arteries and role of purinoceptors in the regulation of pulmonary arterial pressure

(2008) Eun Bok Baek et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Thromboxane A2: Physiology/pathophysiology, cellular signal transduction and pharmacology

(2008) Norimichi Nakahata   PHARMACOLOGY & THERAPEUTICS

Pharmacological characterization of 3-azabicyclo[3,2,1] octane-1-yl-l-leucyl-d-tryptophanyl-d-4-Cl-phenylalanine: A novel ETA receptor-selective antagonist

(2008) Xin Li et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Inhalation of the ETA receptor antagonist LU-135252 selectively attenuates hypoxic pulmonary vasoconstriction

(2007) Bodil Petersen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY