Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances
Authors
Keywords
-
Journal
eLife
Volume 8, Issue -, Pages -
Publisher
eLife Sciences Publications, Ltd
Online
2019-01-15
DOI
10.7554/elife.39856
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer
- (2018) Valentina Grossi et al. NUCLEIC ACIDS RESEARCH
- The MR-Base platform supports systematic causal inference across the human phenome
- (2018) Gibran Hemani et al. eLife
- Relatedness disequilibrium regression estimates heritability without environmental bias
- (2018) Alexander I. Young et al. NATURE GENETICS
- Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
- (2018) Amit V. Khera et al. NATURE GENETICS
- Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating
- (2018) J. Graham Ruby et al. GENETICS
- Four Genome-Wide Association Studies Identify New Extreme Longevity Variants
- (2017) Paola Sebastiani et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Rare and low-frequency coding variants alter human adult height
- (2017) Eirini Marouli et al. NATURE
- Genetic effects on gene expression across human tissues
- (2017) François Aguet et al. NATURE
- A Novel Approach for Pathway Analysis of GWAS Data Highlights Role of BMP Signaling and Muscle Cell Differentiation in Colorectal Cancer Susceptibility
- (2017) Aniket Mishra et al. Twin Research and Human Genetics
- Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity
- (2017) Peter K. Joshi et al. Nature Communications
- Bayesian association scan reveals loci associated with human lifespan and linked biomarkers
- (2017) Aaron F. McDaid et al. Nature Communications
- Identification and characterization of two functional variants in the human longevity gene FOXO3
- (2017) Friederike Flachsbart et al. Nature Communications
- The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature
- (2017) Danny Ben-Avraham et al. Science Advances
- Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants
- (2016) Luke C. Pilling et al. Aging-US
- PhenoScanner: a database of human genotype–phenotype associations
- (2016) James R. Staley et al. BIOINFORMATICS
- Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
- (2016) Zhihong Zhu et al. NATURE GENETICS
- The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)
- (2016) Jacqueline MacArthur et al. NUCLEIC ACIDS RESEARCH
- Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan
- (2016) Peter K. Joshi et al. Nature Communications
- Novel loci and pathways significantly associated with longevity
- (2016) Yi Zeng et al. Scientific Reports
- Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics
- (2016) David Lamparter et al. PLoS Computational Biology
- Estimated Life Expectancy in a Scottish Cohort With Type 1 Diabetes, 2008-2010
- (2015) Shona J. Livingstone et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Increasing Sibling Relative Risk of Survival to Older and Older Ages and the Importance of Precise Definitions of “Aging,” “Life Span,” and “Longevity”
- (2015) Paola Sebastiani et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Partitioning heritability by functional annotation using genome-wide association summary statistics
- (2015) Hilary K Finucane et al. NATURE GENETICS
- LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
- (2015) Brendan K Bulik-Sullivan et al. NATURE GENETICS
- Efficient Bayesian mixed-model analysis increases association power in large cohorts
- (2015) Po-Ru Loh et al. NATURE GENETICS
- The transcriptional landscape of age in human peripheral blood
- (2015) Marjolein J. Peters et al. Nature Communications
- Biological interpretation of genome-wide association studies using predicted gene functions
- (2015) Tune H. Pers et al. Nature Communications
- Involvement of oxysterols in age-related diseases and ageing processes
- (2014) Amira Zarrouk et al. AGEING RESEARCH REVIEWS
- PRSice: Polygenic Risk Score software
- (2014) Jack Euesden et al. BIOINFORMATICS
- Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
- (2014) Joris Deelen et al. HUMAN MOLECULAR GENETICS
- Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu
- (2014) Liis Leitsalu et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy
- (2014) Linda Broer et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Defining the role of common variation in the genomic and biological architecture of adult human height
- (2014) Andrew R Wood et al. NATURE GENETICS
- The Effects of Continuous Theta Burst Stimulation to the Left Dorsolateral Prefrontal Cortex on Executive Function, Food Cravings, and Snack Food Consumption
- (2014) Cassandra J. Lowe et al. PSYCHOSOMATIC MEDICINE
- VEGAS2: Software for More Flexible Gene-Based Testing
- (2014) Aniket Mishra et al. Twin Research and Human Genetics
- Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study
- (2013) Marian Beekman et al. AGING CELL
- Identifying the genomic determinants of aging and longevity in human population studies: Progress and challenges
- (2013) Joris Deelen et al. BIOESSAYS
- RegScan: a GWAS tool for quick estimation of allele effects on continuous traits and their combinations
- (2013) T. Haller et al. BRIEFINGS IN BIOINFORMATICS
- Gene set analysis methods: statistical models and methodological differences
- (2013) H. Maciejewski BRIEFINGS IN BIOINFORMATICS
- Systematic identification of trans eQTLs as putative drivers of known disease associations
- (2013) Harm-Jan Westra et al. NATURE GENETICS
- Dorsolateral prefrontal and orbitofrontal cortex interactions during self-control of cigarette craving
- (2013) Takuya Hayashi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The ageing cortical synapse: hallmarks and implications for cognitive decline
- (2012) John H. Morrison et al. NATURE REVIEWS NEUROSCIENCE
- Genetic Signatures of Exceptional Longevity in Humans
- (2012) Paola Sebastiani et al. PLoS One
- Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
- (2011) Joris Deelen et al. AGING CELL
- Meta-Analysis of Genome-wide Association Studies with Overlapping Subjects
- (2009) Dan-Yu Lin et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Association ofFOXO3Avariation with human longevity confirmed in German centenarians
- (2009) Friederike Flachsbart et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- General Cardiovascular Risk Profile for Use in Primary Care
- (2008) Ralph B. D’Agostino et al. CIRCULATION
- Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
- (2008) Jason D Cooper et al. NATURE GENETICS
- Common variants at CD40 and other loci confer risk of rheumatoid arthritis
- (2008) Soumya Raychaudhuri et al. NATURE GENETICS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started