A pH probe inhibits senescence in mesenchymal stem cells

Rapid Nuclear Exclusion of Hcm1 in Aging Saccharomyces cerevisiae Leads to Vacuolar Alkalization and Replicative Senescence

(2018) Ata Ghavidel et al.   G3-Genes Genomes Genetics

Regulation of V-ATPase activity

(2017) Michael Forgac   Frontiers in Bioscience-Landmark

Bone mesenchymal stem cell-conditioned medium decreases the generation of astrocytes during the process of neural stem cells differentiation

(2017) Huang Fang et al.   JOURNAL OF SPINAL CORD MEDICINE

Caloric Restriction-Induced Extension of Chronological Lifespan Requires Intact Respiration in Budding Yeast

(2017) Young-Yon Kwon et al.   MOLECULES AND CELLS

Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?

(2017) Janusz Blasiak et al.   Oxidative Medicine and Cellular Longevity

Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

(2016) Daniel J. Colacurcio et al.   AGEING RESEARCH REVIEWS

Human Mesenchymal Stem Cells Genetically Engineered to Overexpress Brain-derived Neurotrophic Factor Improve Outcomes in Huntington's Disease Mouse Models

(2016) Kari Pollock et al.   MOLECULAR THERAPY

Characterization of bone marrow-derived mesenchymal stem cells in aging

(2015) Natasha Baker et al.   BONE

Orexin/Hypocretin Activates mTOR Complex 1 (mTORC1) via an Erk/Akt-independent and Calcium-stimulated Lysosome v-ATPase Pathway

(2014) Zhiqiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a small molecule preventing BMSC senescence in vitro by improving intracellular homeostasis via ANXA7 and Hmbox1

(2014) Fang-Wu Wang et al.   RSC Advances

Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification

(2014) Christoph Ruckenstuhl et al.   PLoS Genetics

Autophagy-lysosome pathway associated neuropathology and axonal degeneration in the brains of alpha-galactosidase A-deficient mice

(2014) Michael P Nelson et al.   Acta Neuropathologica Communications

Mesenchymal Stem Cells for Treatment of Myocardial Infarction

(2014) Il-Kwon Ko et al.   International Journal of Stem Cells

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

Lysosomal Membrane Proteins and Their Central Role in Physiology

(2013) Michael Schwake et al.   TRAFFIC

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome

(2012) Line De Kimpe et al.   AGE

Cathepsin Cleavage of Sirtuin 1 in Endothelial Progenitor Cells Mediates Stress-Induced Premature Senescence

(2012) Jun Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

(2012) Adam L. Hughes et al.   NATURE

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Ion flux and the function of endosomes and lysosomes: pH is just the start

(2010) Cameron C. Scott et al.   BIOESSAYS

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE