Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1I249/M280 Variant

Multiple Sclerosis

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Lipocalin-2 regulates adult neurogenesis and contextual discriminative behaviours

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Fractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy

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CX3CR1-dependent recruitment of mature NK cells into the central nervous system contributes to control autoimmune neuroinflammation

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Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant

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Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina

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Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

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The role of fractalkine (CX3CL1) in regulation of CD4+ cell migration to the central nervous system in patients with relapsing–remitting multiple sclerosis

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Functional classification of memory CD8+ T cells by CX3CR1 expression

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Lipocalin-2 Protein Deficiency Ameliorates Experimental Autoimmune Encephalomyelitis

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Comparison of microglia and infiltrating CD11c+ cells as antigen presenting cells for T cell proliferation and cytokine response

(2014) Agnieszka Wlodarczyk et al.   Journal of Neuroinflammation

Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis

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Regulation of Adaptive Immunity by the Fractalkine Receptor during Autoimmune Inflammation

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Epigenome-wide differences in pathology-free regions of multiple sclerosis–affected brains

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Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

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Lipocalin 2 Deficiency Dysregulates Iron Homeostasis and Exacerbates Endotoxin-Induced Sepsis

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The association of V249I and T280M fractalkine receptor haplotypes with disease course of multiple sclerosis

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The Protein Data Bank at 40: Reflecting on the Past to Prepare for the Future

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Lipocalin 2 is present in the EAE brain and is modulated by natalizumab

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Analyses of phenotypic and functional characteristics of CX3CR1-expressing natural killer cells

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Lipocalin-2 Is a Chemokine Inducer in the Central Nervous System

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The Fractalkine Receptor but Not CCR2 Is Present on Microglia from Embryonic Development throughout Adulthood

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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

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Reorganizing the protein space at the Universal Protein Resource (UniProt)

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Isolation of Brain and Spinal Cord Mononuclear Cells Using Percoll Gradients

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Transplantation of Ciliary Neurotrophic Factor-Expressing Adult Oligodendrocyte Precursor Cells Promotes Remyelination and Functional Recovery after SpinalCord Injury

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Regulation of Tau Pathology by the Microglial Fractalkine Receptor

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Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

Iron is essential for oligodendrocyte genesis following intraspinal macrophage activation

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Protein structure prediction on the Web: a case study using the Phyre server

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Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues

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Deletion of the mouse RegIII  (Reg2) gene disrupts ciliary neurotrophic factor signaling and delays myelination of mouse cranial motor neurons

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QMEAN: A comprehensive scoring function for model quality assessment

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