Myelin-reactive antibodies initiate T cell-mediated CNS autoimmune disease by opsonization of endogenous antigen

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B Cell Antigen Presentation Is Sufficient To Drive Neuroinflammation in an Animal Model of Multiple Sclerosis

(2015) Chelsea R. Parker Harp et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of action of therapeutic antibodies for cancer

(2015) J.M. Redman et al.   MOLECULAR IMMUNOLOGY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Proinflammatory GM-CSF–producing B cells in multiple sclerosis and B cell depletion therapy

(2015) Rui Li et al.   Science Translational Medicine

Tumor Antigen-Specific Monoclonal Antibodies and Induction of T-Cell Immunity

(2014) Sumita Trivedi et al.   SEMINARS IN ONCOLOGY

Neuromyelitis Optica Spectrum Disorders With Aquaporin-4 and Myelin-Oligodendrocyte Glycoprotein Antibodies

(2014) Joanna Kitley et al.   JAMA Neurology

Intrathecal anti-CD20 efficiently depletes meningeal B cells in CNS autoimmunity

(2014) Klaus Lehmann-Horn et al.   Annals of Clinical and Translational Neurology

The Pathology of an Autoimmune Astrocytopathy: Lessons Learned from Neuromyelitis Optica

(2013) Claudia F. Lucchinetti et al.   BRAIN PATHOLOGY

Diagnosis and Management of Paraneoplastic Neurologic Disorders

(2013) Myrna R. Rosenfeld et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

MHC class II–dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies

(2013) Nicolas Molnarfi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crosstalk between Human IgG Isotypes and Murine Effector Cells

(2012) M. B. Overdijk et al.   JOURNAL OF IMMUNOLOGY

Immunotherapy for Alzheimer's Disease: Rational Basis in Ongoing Clinical Trials

(2011) Manuel Menendez-Gonzalez et al.   CURRENT PHARMACEUTICAL DESIGN

Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

(2011) Allal Boutajangout et al.   JOURNAL OF NEUROCHEMISTRY

Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders

(2011) Simone Mader et al.   Journal of Neuroinflammation

Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial

(2011) Ludwig Kappos et al.   LANCET

B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity

(2010) Martin S. Weber et al.   ANNALS OF NEUROLOGY

Temporal dynamics of anti-MOG antibodies in CNS demyelinating diseases

(2010) Franziska Di Pauli et al.   CLINICAL IMMUNOLOGY

The role of dendritic cells in the pathogenesis of systemic lupus erythematosus

(2010) Justin H Fransen et al.   ARTHRITIS RESEARCH & THERAPY

Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells

(2009) Bernadette Pöllinger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce “oligoclonal bands”

(2009) Hans-Christian von Büdingen et al.   JOURNAL OF NEUROIMMUNOLOGY

Surgical excision of CNS-draining lymph nodes reduces relapse severity in chronic-relapsing experimental autoimmune encephalomyelitis

(2008) Marloes van Zwam et al.   JOURNAL OF PATHOLOGY

Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis

(2008) Birgit Obermeier et al.   NATURE MEDICINE

Systemic Lupus Erythematosus

(2008) Anisur Rahman et al.   NEW ENGLAND JOURNAL OF MEDICINE

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE