Peroxisome Proliferator-activated Receptors and Alzheimer's Disease: Hitting the Blood–Brain Barrier
Published 2013 View Full Article
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Title
Peroxisome Proliferator-activated Receptors and Alzheimer's Disease: Hitting the Blood–Brain Barrier
Authors
Keywords
Blood–brain barrier, Oxidative stress, Alzheimers disease, PPARs
Journal
MOLECULAR NEUROBIOLOGY
Volume 48, Issue 3, Pages 438-451
Publisher
Springer Nature
Online
2013-03-13
DOI
10.1007/s12035-013-8435-5
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Note: Only part of the references are listed.- Activation of Peroxisome Proliferator-Activated Receptor (PPAR ) Suppresses Rho GTPases in Human Brain Microvascular Endothelial Cells and Inhibits Adhesion and Transendothelial Migration of HIV-1 Infected Monocytes
- (2014) S. H. Ramirez et al. JOURNAL OF IMMUNOLOGY
- Neurovascular Dysfunction and Faulty Amyloid -Peptide Clearance in Alzheimer Disease
- (2013) A. P. Sagare et al. Cold Spring Harbor Perspectives in Medicine
- Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease
- (2013) D. M. Holtzman et al. Cold Spring Harbor Perspectives in Medicine
- Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood–brain barrier: Protection by the antioxidant N-acetylcysteine
- (2012) Michelle A. Erickson et al. BRAIN BEHAVIOR AND IMMUNITY
- Pioglitazone treatment increases COX-2-derived prostacyclin production and reduces oxidative stress in hypertensive rats: role in vascular function
- (2012) Raquel Hernanz et al. BRITISH JOURNAL OF PHARMACOLOGY
- Blood-brain barrier dysfunction and epilepsy: Pathophysiologic role and therapeutic approaches
- (2012) Nicola Marchi et al. EPILEPSIA
- Blood-brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy
- (2012) Uwe Heinemann et al. GLIA
- Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity
- (2012) Andrew D. Patterson et al. HEPATOLOGY
- Peroxisome Proliferator-Activated Receptor-γ Activation With Angiotensin II Type 1 Receptor Blockade Is Pivotal for the Prevention of Blood-Brain Barrier Impairment and Cognitive Decline in Type 2 Diabetic Mice
- (2012) Li-Juan Min et al. HYPERTENSION
- Apolipoprotein E3 (ApoE3) but Not ApoE4 Protects against Synaptic Loss through Increased Expression of Protein Kinase Cϵ
- (2012) Abhik Sen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- No Evidence for Additional Blood–Brain Barrier P-Glycoprotein Dysfunction in Alzheimer's Disease Patients with Microbleeds
- (2012) Daniëlle ME van Assema et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease
- (2012) Rashid Deane et al. JOURNAL OF CLINICAL INVESTIGATION
- 1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells
- (2012) Matthew R. Durk et al. JOURNAL OF NEUROCHEMISTRY
- Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier
- (2012) Michelle A Erickson et al. Journal of Neuroinflammation
- LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid-
- (2012) T. Kanekiyo et al. JOURNAL OF NEUROSCIENCE
- A 1-42-RAGE Interaction Disrupts Tight Junctions of the Blood-Brain Barrier Via Ca2+-Calcineurin Signaling
- (2012) S.-Y. Kook et al. JOURNAL OF NEUROSCIENCE
- Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease
- (2012) S. Mandrekar-Colucci et al. JOURNAL OF NEUROSCIENCE
- PPAR gamma activation protects the brain against microvascular dysfunction in sepsis
- (2012) C.V. Araújo et al. MICROVASCULAR RESEARCH
- Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) and Neurodegenerative Disorders
- (2012) Yu-Chang Chen et al. MOLECULAR NEUROBIOLOGY
- The Ethics of Early Evidence — Preparing for a Possible Breakthrough in Alzheimer's Disease
- (2012) Justin Lowenthal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Preclinical Success against Alzheimer's Disease with an Old Drug
- (2012) Frank M. LaFerla NEW ENGLAND JOURNAL OF MEDICINE
- Metabolic Health and Nuclear-Receptor Sensitivity
- (2012) Anthony N. Hollenberg NEW ENGLAND JOURNAL OF MEDICINE
- Protection from liver fibrosis by a peroxisome proliferator-activated receptor agonist
- (2012) K. Iwaisako et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver
- (2012) N. Sehgal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ApoE-Directed Therapeutics Rapidly Clear -Amyloid and Reverse Deficits in AD Mouse Models
- (2012) P. E. Cramer et al. SCIENCE
- PPAR and Oxidative Stress: Con() Catenating NRF2 and FOXO
- (2012) Simone Polvani et al. PPAR Research
- New Insights into the Role of Peroxisome Proliferator-Activated Receptors in Regulating the Inflammatory Response after Tissue Injury
- (2012) Miriam D. Neher et al. PPAR Research
- Perlecan and the Blood-Brain Barrier: Beneficial Proteolysis?
- (2012) Jill Roberts et al. Frontiers in Pharmacology
- Blood–brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene
- (2012) Daniëlle ME van Assema et al. EJNMMI Research
- Nuclear receptors as therapeutic targets for Alzheimer's disease
- (2011) Shweta Mandrekar-Colucci et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- PPARα and PPARγ protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling
- (2011) Wen Huang et al. FASEB JOURNAL
- Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter
- (2011) Elodie Martin et al. HUMAN MOLECULAR GENETICS
- Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in anin VitroBlood-Brain Barrier Model
- (2011) Kazuchika Nishitsuji et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Peroxisome Proliferator-activated Receptor α (PPARα) Induces PPARγ Coactivator 1α (PGC-1α) Gene Expression and Contributes to Thermogenic Activation of Brown Fat
- (2011) Elayne Hondares et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice
- (2011) Markus Krohn et al. JOURNAL OF CLINICAL INVESTIGATION
- Peroxisome proliferator-activated receptor-γ activation reduces cyclooxygenase-2 expression in vascular smooth muscle cells from hypertensive rats by interfering with oxidative stress
- (2011) Angela Martín et al. JOURNAL OF HYPERTENSION
- From the liver to the blood-brain barrier: An interconnected system regulating brain amyloid-β levels
- (2011) Abhay P. Sagare et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Peripheral reduction of β-amyloid is sufficient to reduce brain β-amyloid: Implications for Alzheimer's disease
- (2011) J. Gregor Sutcliffe et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Alzheimer's disease
- (2011) Clive Ballard et al. LANCET
- Carbon nanotube-mediated wireless cell permeabilization: drug and gene uptake
- (2011) Vittoria Raffa et al. Nanomedicine
- The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
- (2011) Eric Karran et al. NATURE REVIEWS DRUG DISCOVERY
- Association of ApoE and LRP mRNA levels with dementia and AD neuropathology
- (2011) Afia Akram et al. NEUROBIOLOGY OF AGING
- Peroxisome Proliferator-Activated Receptor Regulation of miR-15a in Ischemia-Induced Cerebral Vascular Endothelial Injury
- (2010) K. J. Yin et al. JOURNAL OF NEUROSCIENCE
- Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress
- (2010) K N Manolopoulos et al. MOLECULAR PSYCHIATRY
- Neuropathology of Alzheimer's Disease
- (2010) Daniel P. Perl MOUNT SINAI JOURNAL OF MEDICINE
- Association of CLU and PICALM variants with Alzheimer's disease
- (2010) M. Ilyas Kamboh et al. NEUROBIOLOGY OF AGING
- Peripherally Applied A -Containing Inoculates Induce Cerebral -Amyloidosis
- (2010) Y. S. Eisele et al. SCIENCE
- Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease
- (2009) Robert D. Bell et al. ACTA NEUROPATHOLOGICA
- The Role of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) in Alzheimer’s Disease
- (2009) Qingguang Jiang et al. CNS DRUGS
- A PPARdelta Agonist Reduces Amyloid Burden and Brain Inflammation in a Transgenic Mouse Model of Alzheimers Disease
- (2009) Sergey Kalinin et al. Current Alzheimer Research
- Peroxisome Proliferator-Activated Receptor-α Activation Protects Brain Capillary Endothelial Cells from Oxygen-Glucose Deprivation-Induced Hyperpermeability in the Blood-Brain Barrier
- (2009) Caroline Mysiorek et al. CURRENT NEUROVASCULAR RESEARCH
- Brain drug targeting: a computational approach for overcoming blood–brain barrier
- (2009) Ahmad Reza Mehdipour et al. DRUG DISCOVERY TODAY
- PPARα and PPARγ attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities
- (2009) Wen Huang et al. FASEB JOURNAL
- PGC-1α and PGC-1β Regulate Mitochondrial Density in Neurons
- (2009) Przemyslaw Wareski et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model of Alzheimer's disease
- (2009) E M Toledo et al. MOLECULAR PSYCHIATRY
- Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
- (2009) Guojun Bu NATURE REVIEWS NEUROSCIENCE
- Structure and function of the blood–brain barrier
- (2009) N. Joan Abbott et al. NEUROBIOLOGY OF DISEASE
- Neuropsychological Assessment of Dementia
- (2008) David P. Salmon et al. Annual Review of Psychology
- Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease
- (2008) Nikolai D Belyaev et al. EMBO REPORTS
- The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease
- (2008) Nibaldo C Inestrosa et al. Molecular Neurodegeneration
- In Vivo Imaging Reveals Selective Peroxisome Proliferator Activated Receptor Modulator Activity of the Synthetic Ligand 3-(1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid (MK-886)
- (2008) A. Biserni et al. MOLECULAR PHARMACOLOGY
- Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis
- (2008) Scott A. Small et al. NEURON
- ApoE Promotes the Proteolytic Degradation of Aβ
- (2008) Qingguang Jiang et al. NEURON
- The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
- (2008) Berislav V. Zlokovic NEURON
- Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease
- (2008) P. Hemachandra Reddy et al. TRENDS IN MOLECULAR MEDICINE
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