The LKB1–AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria

AMPK-α1 or AMPK-α2 Deletion in Smooth Muscles Does Not Affect the Hypoxic Ventilatory Response or Systemic Arterial Blood Pressure Regulation During Hypoxia

(2018) Sandy MacMillan et al.   Frontiers in Physiology

AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species

(2017) Rebecca C. Rabinovitch et al.   Cell Reports

Protective Roles of Endothelial AMP-Activated Protein Kinase Against Hypoxia-Induced Pulmonary Hypertension in MiceNovelty and Significance

(2016) Junichi Omura et al.   CIRCULATION RESEARCH

AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours

(2016) Fiona A. Ross et al.   FEBS Journal

AMP-activated protein kinase inhibits Kv1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation

(2016) Javier Moral-Sanz et al.   JOURNAL OF PHYSIOLOGY-LONDON

The responses of pulmonary and systemic circulation and airway to anaphylactic mediators in anesthetized BALB/c mice

(2016) Mofei Wang et al.   LIFE SCIENCES

AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism

(2015) Miranda M. Sung et al.   CARDIOVASCULAR RESEARCH

Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction

(2015) Bethany E. Schaffer et al.   Cell Metabolism

Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK

(2014) Roger W. Hunter et al.   CHEMISTRY & BIOLOGY

AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity

(2014) Louise Lantier et al.   FASEB JOURNAL

Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP

(2014) F. Romana Auciello et al.   FEBS LETTERS

The Sugen 5416/Hypoxia Mouse Model of Pulmonary Hypertension Revisited: Long-Term Follow-Up

(2014) Sally H. Vitali et al.   Pulmonary Circulation

Decreased Kv1.5 expression in intrauterine growth retardation rats with exaggerated pulmonary hypertension

(2013) Ying Lv et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Adenosine Monophosphate–Activated Protein Kinase Is Required for Pulmonary Artery Smooth Muscle Cell Survival and the Development of Hypoxic Pulmonary Hypertension

(2013) Joyce Christina F. Ibe et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

(2013) Graeme J. Gowans et al.   Cell Metabolism

Mammalian Target of Rapamycin Complex 2 (mTORC2) Coordinates Pulmonary Artery Smooth Muscle Cell Metabolism, Proliferation, and Survival in Pulmonary Arterial Hypertension

(2013) Dmitry A. Goncharov et al.   CIRCULATION

Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2

(2013) Siddhesh Aras et al.   NUCLEIC ACIDS RESEARCH

Hypoxic Pulmonary Vasoconstriction

(2012) J. T. Sylvester et al.   PHYSIOLOGICAL REVIEWS

A Fluorescent Reporter of AMPK Activity and Cellular Energy Stress

(2011) Peiling Tsou et al.   Cell Metabolism

Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels

(2011) P. T. Mungai et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability

(2011) N. Ikematsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New perspectives for the treatment of pulmonary hypertension

(2010) Reshma S Baliga et al.   BRITISH JOURNAL OF PHARMACOLOGY

Noninvasive Assessment of Murine Pulmonary Arterial Pressure

(2010) Hélène B. Thibault et al.   Circulation-Cardiovascular Imaging

Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)

(2009) et al.   EUROPEAN HEART JOURNAL

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

(2009) Brooke M. Emerling et al.   FREE RADICAL BIOLOGY AND MEDICINE

AMPKα2 counteracts the development of cardiac hypertrophy induced by isoproterenol

(2008) Elham Zarrinpashneh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SM22 -targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis

(2008) N. El-Bizri et al.   DEVELOPMENT

AMP-activated protein kinase and hypoxic pulmonary vasoconstriction

(2008) Tom P. Robertson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY