Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis

MEK drives BRAF activation through allosteric control of KSR proteins

(2018) Hugo Lavoie et al.   NATURE

The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants

(2018) Jimin Yuan et al.   ONCOGENE

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

(2016) Scott A. Foster et al.   CANCER CELL

Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120

(2016) S.-H. Chen et al.   Cancer Discovery

Alike but Different: RAF Paralogs and Their Signaling Outputs

(2015) Enrico Desideri et al.   CELL

MAP2K1andMAP3K1mutations in langerhans cell histiocytosis

(2015) David S. Nelson et al.   GENES CHROMOSOMES & CANCER

Extreme Outlier Analysis Identifies Occult Mitogen-Activated Protein Kinase Pathway Mutations in Patients With Low-Grade Serous Ovarian Cancer

(2015) Rachel N. Grisham et al.   JOURNAL OF CLINICAL ONCOLOGY

The Tetrahymena telomerase p75–p45–p19 subcomplex is a unique CST complex

(2015) Bingbing Wan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Grb2 monomer–dimer equilibrium determines normal versus oncogenic function

(2015) Zamal Ahmed et al.   Nature Communications

Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms

(2015) E. L. Diamond et al.   Cancer Discovery

The Tetrahymena telomerase p75–p45–p19 subcomplex is a unique CST complex

(2015) Bingbing Wan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

High prevalence of somatic MAP2K1 mutations in BRAF V600E-negative Langerhans cell histiocytosis

(2014) N. A. Brown et al.   BLOOD

Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis

(2014) R. Chakraborty et al.   BLOOD

Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling

(2014) Jacob R. Haling et al.   CANCER CELL

Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors

(2014) Piro Lito et al.   CANCER CELL

“RAF” neighborhood: Protein-protein interaction in the Raf/Mek/Erk pathway

(2014) Botond Cseh et al.   FEBS LETTERS

Kinase Regulation by Hydrophobic Spine Assembly in Cancer

(2014) Jiancheng Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

Kinases and Pseudokinases: Lessons from RAF

(2014) A. S. Shaw et al.   MOLECULAR AND CELLULAR BIOLOGY

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation

(2014) Neroshan Thevakumaran et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Calmodulin and PI(3,4,5)P3 cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production

(2014) X. Wang et al.   Science Signaling

Oncogene Mimicry as a Mechanism of Primary Resistance to BRAF Inhibitors

(2014) Martin L. Sos et al.   Cell Reports

Pseudokinases from a structural perspective

(2013) Susan S. Taylor et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers

(2013) Jiancheng Hu et al.   CELL

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

(2013) Georgia Hatzivassiliou et al.   NATURE

High prevalence of MAP2K1 mutations in variant and IGHV4-34–expressing hairy-cell leukemias

(2013) Joshua J Waterfall et al.   NATURE GENETICS

The Salmonella Kinase SteC Targets the MAP Kinase MEK to Regulate the Host Actin Cytoskeleton

(2012) Charlotte Odendall et al.   Cell Host & Microbe

Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling

(2012) Michael Röring et al.   EMBO JOURNAL

MEK1/2 dual-specificity protein kinases: Structure and regulation

(2011) Robert Roskoski   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

(2011) Poulikos I. Poulikakos et al.   NATURE

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

(2011) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein kinases: evolution of dynamic regulatory proteins

(2010) Susan S. Taylor et al.   TRENDS IN BIOCHEMICAL SCIENCES

Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors

(2009) Thierry O. Fischmann et al.   BIOCHEMISTRY

A Mek1–Mek2 heterodimer determines the strength and duration of the Erk signal

(2009) Federica Catalanotti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lsc activity is controlled by oligomerization and regulates integrin adhesion

(2007) Jiancheng Hu et al.   MOLECULAR IMMUNOLOGY