The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants
Authors
Keywords
-
Journal
ONCOGENE
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2018-06-21
DOI
10.1038/s41388-018-0365-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profiles
- (2017) P Jain et al. ONCOGENE
- The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function
- (2017) Lixin Wan et al. Cancer Discovery
- Alternative genetic mechanisms of BRAF activation in Langerhans cell histiocytosis
- (2016) Rikhia Chakraborty et al. BLOOD
- Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2
- (2016) Scott A. Foster et al. CANCER CELL
- How Do Protein Kinases Take a Selfie (Autophosphorylate)?
- (2016) Jonah Beenstock et al. TRENDS IN BIOCHEMICAL SCIENCES
- Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120
- (2016) S.-H. Chen et al. Cancer Discovery
- Alike but Different: RAF Paralogs and Their Signaling Outputs
- (2015) Enrico Desideri et al. CELL
- The distribution ofBRAFgene fusions in solid tumors and response to targeted therapy
- (2015) Jeffrey S. Ross et al. INTERNATIONAL JOURNAL OF CANCER
- Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer
- (2015) Christopher C. Valley et al. MOLECULAR BIOLOGY OF THE CELL
- Regulation of RAF protein kinases in ERK signalling
- (2015) Hugo Lavoie et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway
- (2015) Xiaolin Nan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Landscape of gene fusions in epithelial cancers: seq and ye shall find
- (2015) Chandan Kumar-Sinha et al. Genome Medicine
- Somatic activating ARAF mutations in Langerhans cell histiocytosis
- (2014) D. S. Nelson et al. BLOOD
- Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling
- (2014) Jacob R. Haling et al. CANCER CELL
- BRAF Inhibitor Resistance Mechanisms in Metastatic Melanoma: Spectrum and Clinical Impact
- (2014) H. Rizos et al. CLINICAL CANCER RESEARCH
- “RAF” neighborhood: Protein-protein interaction in the Raf/Mek/Erk pathway
- (2014) Botond Cseh et al. FEBS LETTERS
- Kinase Regulation by Hydrophobic Spine Assembly in Cancer
- (2014) Jiancheng Hu et al. MOLECULAR AND CELLULAR BIOLOGY
- Kinases and Pseudokinases: Lessons from RAF
- (2014) A. S. Shaw et al. MOLECULAR AND CELLULAR BIOLOGY
- Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation
- (2014) Neroshan Thevakumaran et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration
- (2014) J. Mooz et al. Science Signaling
- Calmodulin and PI(3,4,5)P3 cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production
- (2014) X. Wang et al. Science Signaling
- Dimerization-induced allostery in protein kinase regulation
- (2014) Hugo Lavoie et al. TRENDS IN BIOCHEMICAL SCIENCES
- The landscape of kinase fusions in cancer
- (2014) Nicolas Stransky et al. Nature Communications
- Pseudokinases from a structural perspective
- (2013) Susan S. Taylor et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers
- (2013) Jiancheng Hu et al. CELL
- Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling
- (2012) Michael Röring et al. EMBO JOURNAL
- Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
- (2012) Axel Hauschild et al. LANCET
- Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma
- (2012) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers
- (2012) A P Rebocho et al. ONCOGENE
- A Conserved Glu–Arg Salt Bridge Connects Coevolved Motifs That Define the Eukaryotic Protein Kinase Fold
- (2011) Jie Yang et al. JOURNAL OF MOLECULAR BIOLOGY
- RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
- (2011) Poulikos I. Poulikakos et al. NATURE
- Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF
- (2011) J. Hu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
- (2010) Sonja J. Heidorn et al. CELL
- RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
- (2010) Poulikos I. Poulikakos et al. NATURE
- RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
- (2010) Georgia Hatzivassiliou et al. NATURE
- Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
- (2010) Gideon Bollag et al. NATURE
- Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma
- (2010) Nallasivam Palanisamy et al. NATURE MEDICINE
- Protein kinases: evolution of dynamic regulatory proteins
- (2010) Susan S. Taylor et al. TRENDS IN BIOCHEMICAL SCIENCES
- Monomer−Dimer Equilibrium in Glutathione Transferases: A Critical Re-Examination
- (2009) Raffaele Fabrini et al. BIOCHEMISTRY
- A RasGTP-Induced Conformational Change in C-RAF Is Essential for Accurate Molecular Recognition
- (2009) Kayo Hibino et al. BIOPHYSICAL JOURNAL
- Impact of Feedback Phosphorylation and Raf Heterodimerization on Normal and Mutant B-Raf Signaling
- (2009) D. A. Ritt et al. MOLECULAR AND CELLULAR BIOLOGY
- A dimerization-dependent mechanism drives RAF catalytic activation
- (2009) Thanashan Rajakulendran et al. NATURE
- Lsc activity is controlled by oligomerization and regulates integrin adhesion
- (2007) Jiancheng Hu et al. MOLECULAR IMMUNOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started