Expanding the clinical relevance of the 5′-nucleotidase cN-II/NT5C2

Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis

(2018) Xing-Cheng Zhao et al.   BMC Medical Genomics

Purine-related metabolites and their converting enzymes are altered in frontal, parietal and temporal cortex at early stages of Alzheimer's disease pathology

(2018) Patricia Alonso-Andrés et al.   BRAIN PATHOLOGY

Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia

(2018) Chelsea L. Dieck et al.   CANCER CELL

Clinical and genetic spectrum of AMPD2-related pontocerebellar hypoplasia type 9

(2018) Fanny Kortüm et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia

(2018) Gannie Tzoneva et al.   NATURE

Cell-subtype-specific changes in adenosine pathways in schizophrenia

(2018) Sinead Marie O’Donovan et al.   NEUROPSYCHOPHARMACOLOGY

Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia

(2018) Jacqueline Lehmann-Che et al.   Nature Communications

Cytosolic 5′-Nucleotidase II Silencing in a Human Lung Carcinoma Cell Line Opposes Cancer Phenotype with a Concomitant Increase in p53 Phosphorylation

(2018) Rossana Pesi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mutational profiling of acute lymphoblastic leukemia with testicular relapse

(2017) Ling-Wen Ding et al.   Journal of Hematology & Oncology

Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia

(2017) P Richter-Pechańska et al.   Blood Cancer Journal

The cytosolic 5’-nucleotidase cN-II lowers the adaptability to glucose deprivation in human breast cancer cells

(2017) Gabriel Bricard et al.   Oncotarget

Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East AsiansCLINICAL PERSPECTIVE

(2017) Changwei Li et al.   Circulation-Cardiovascular Genetics

Whole genome sequencing identifies a novel homozygous exon deletion in the NT5C2 gene in a family with intellectual disability and spastic paraplegia

(2017) Hossein Darvish et al.   npj Genomic Medicine

The adenosine generating enzymes CD39/CD73 control microglial processes ramification in the mouse brain

(2017) Marina Matyash et al.   PLoS One

Genome-wide significant schizophrenia risk variation on chromosome 10q24 is associated with alteredcis-regulation ofBORCS7,AS3MT, andNT5C2in the human brain

(2016) Rodrigo R. R. Duarte et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Replication of genome-wide association study (GWAS) susceptibility loci in a Latino bipolar disorder cohort

(2016) Suzanne Gonzalez et al.   BIPOLAR DISORDERS

Schizophrenia risk variants affecting microRNA function and site-specific regulation of NT5C2 by miR-206

(2016) Mads Engel Hauberg et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia

(2016) Koichi Oshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The rs11191580 variant of the NT5C2 gene is associated with schizophrenia and symptom severity in a South Chinese Han population: evidence from GWAS

(2016) Zhen Li et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Two-stage replication of previous genome-wide association studies of AS3MT-CNNM2-NT5C2 gene cluster region in a large schizophrenia case–control sample from Han Chinese population

(2016) Fanglin Guan et al.   SCHIZOPHRENIA RESEARCH

Determination of the enzymatic activity of cytosolic 5′-nucleotidase cN-II in cancer cells: development of a simple analytical method and related cell line models

(2015) Lars Petter Jordheim et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation

(2015) J. B. Kunz et al.   HAEMATOLOGICA

Cell proliferation and drug sensitivity of human glioblastoma cells are altered by the stable modulation of cytosolic 5′-nucleotidase II

(2015) F. Cividini et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Obesity Genes and Risk of Major Depressive Disorder in a Multiethnic Population

(2015) Zainab Samaan et al.   JOURNAL OF CLINICAL PSYCHIATRY

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Purine metabolism gene deregulation in Parkinson's disease

(2015) Paula Garcia-Esparcia et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Leukemia Relapse-Associated Mutation of NT5C2 Gene is Rare in de Novo Acute Leukemias and Solid Tumors

(2015) Hye Rim Oh et al.   PATHOLOGY & ONCOLOGY RESEARCH

Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia

(2015) Xiaotu Ma et al.   Nature Communications

Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation

(2015) J. B. Kunz et al.   HAEMATOLOGICA

Cytosolic 5’-Nucleotidase II Interacts with the Leucin Rich Repeat of NLR Family Member Ipaf

(2015) Federico Cividini et al.   PLoS One

Hereditary spastic paraplegia: Clinical-genetic characteristics and evolving molecular mechanisms

(2014) Temistocle Lo Giudice et al.   EXPERIMENTAL NEUROLOGY

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

(2014) Wanqing Wen et al.   HUMAN MOLECULAR GENETICS

Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders

(2014) G. Novarino et al.   SCIENCE

Hereditary Spastic Paraplegia: Clinical Principles and Genetic Advances

(2014) John Fink   SEMINARS IN NEUROLOGY

AMPD2 Regulates GTP Synthesis and Is Mutated in a Potentially Treatable Neurodegenerative Brainstem Disorder

(2013) Naiara Akizu et al.   CELL

Therapeutic Perspectives for cN-II in Cancer.

(2013) Lars Jordheim et al.   CURRENT MEDICINAL CHEMISTRY

Genome-Wide Association Study Meta-Analysis Reveals Transethnic Replication of Mean Arterial and Pulse Pressure Loci

(2013) Tanika N. Kelly et al.   HYPERTENSION

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia

(2013) Julia A Meyer et al.   NATURE GENETICS

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL

(2013) Gannie Tzoneva et al.   NATURE MEDICINE

A Comprehensive Family-Based Replication Study of Schizophrenia Genes

(2013) Karolina A. Aberg et al.   JAMA Psychiatry

Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3β/PP1 imbalance

(2012) Celia López-Menéndez et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder

(2012) S E Bergen et al.   MOLECULAR PSYCHIATRY

Suppression of 5′-Nucleotidase Enzymes Promotes AMP-activated Protein Kinase (AMPK) Phosphorylation and Metabolism in Human and Mouse Skeletal Muscle

(2011) Sameer S. Kulkarni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic variations in the CYP17A1 and NT5C2 genes are associated with a reduction in visceral and subcutaneous fat areas in Japanese women

(2011) Kikuko Hotta et al.   JOURNAL OF HUMAN GENETICS

Deep sequencing reveals 50 novel genes for recessive cognitive disorders

(2011) Hossein Najmabadi et al.   NATURE

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

(2011) Georg B. Ehret et al.   NATURE

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

(2011) Norihiro Kato et al.   NATURE GENETICS

Neuroglial interactions mediated by purinergic signalling in the pathophysiology of CNS disorders

(2011) Carlos Matute et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Genome-wide association study identifies eight loci associated with blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Genome-wide association study of blood pressure and hypertension

(2009) Daniel Levy et al.   NATURE GENETICS

Autosomal recessive spastic paraplegia (SPG45) with mental retardation maps to 10q24.3–q25.1

(2009) Umut Dursun et al.   NEUROGENETICS

Differential Allelic Expression in Leukoblast from Patients with Acute Myeloid Leukemia Suggests Genetic Regulation of CDA, DCK, NT5C2, NT5C3, and TP53

(2008) L. P. Jordheim et al.   DRUG METABOLISM AND DISPOSITION