Minocycline prevents the development of depression-like behavior and hippocampal inflammation in a rat model of Alzheimer’s disease

Activation of CRF/CRFR1 signaling in the basolateral nucleus of the amygdala contributes to chronic forced swim-induced depressive-like behaviors in rats

(2018) Lin Chen et al.   BEHAVIOURAL BRAIN RESEARCH

ATP-sensitive potassium-channel inhibitor glibenclamide attenuates HPA axis hyperactivity, depression- and anxiety-related symptoms in a rat model of Alzheimer's disease

(2018) Mohammad Hossein Esmaeili et al.   BRAIN RESEARCH BULLETIN

Anxiolytic- and antidepressant-like effects of Silymarin compared to diazepam and fluoxetine in a mouse model of mild traumatic brain injury

(2018) Morteza Kosari-Nasab et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Apathy and Depression in Mild Alzheimer's Disease: A Cross-Sectional Study Using Diagnostic Criteria

(2018) Michel Benoit et al.   JOURNAL OF ALZHEIMERS DISEASE

Small litter size impairs spatial memory and increases anxiety- like behavior in a strain-dependent manner in male mice

(2018) Ali-Akbar Salari et al.   Scientific Reports

Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline

(2017) Hong-Tao Wang et al.   NEUROTOXICITY RESEARCH

Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus

(2017) Xiaoyu Song et al.   PHYSIOLOGY & BEHAVIOR

Antidepressant drugs for beta amyloid-induced depression: A new standpoint?

(2017) Stefania Schiavone et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Minocycline reduces inflammatory parameters in the brain structures and serum and reverses memory impairment caused by the administration of amyloid β (1-42) in mice

(2017) Michelle Lima Garcez et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Minocycline does not evoke anxiolytic and antidepressant-like effects in C57BL/6 mice

(2016) M.A. Vogt et al.   BEHAVIOURAL BRAIN RESEARCH

Fluoxetine normalizes the effects of prenatal maternal stress on depression- and anxiety-like behaviors in mouse dams and male offspring

(2016) Ali-Akbar Salari et al.   BEHAVIOURAL BRAIN RESEARCH

Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-β 1-42 peptide in mice

(2016) Leandro Cattelan Souza et al.   BRAIN BEHAVIOR AND IMMUNITY

Developmental minocycline treatment reverses the effects of neonatal immune activation on anxiety- and depression-like behaviors, hippocampal inflammation, and HPA axis activity in adult mice

(2016) Jafar Majidi et al.   BRAIN RESEARCH BULLETIN

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Testosterone has antidepressant-like efficacy and facilitates imipramine-induced neuroplasticity in male rats exposed to chronic unpredictable stress

(2016) Steven R. Wainwright et al.   HORMONES AND BEHAVIOR

Therapeutic effects of minocycline on mild-to-moderate depression in HIV patients

(2016) Hamid Emadi-Kouchak et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Minocycline Transiently Reduces Microglia/Macrophage Activation but Exacerbates Cognitive Deficits Following Repetitive Traumatic Brain Injury in the Neonatal Rat

(2016) Lauren A. Hanlon et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-  Oligomers in Mice

(2016) J. H. Ledo et al.   JOURNAL OF NEUROSCIENCE

SB203580 reverses memory deficits and depression-like behavior induced by microinjection of Aβ1–42 into hippocampus of mice

(2016) Jiejie Guo et al.   METABOLIC BRAIN DISEASE

Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression

(2016) Ming-ming Tang et al.   PHYSIOLOGY & BEHAVIOR

Minocycline Attenuates Depressive-Like Behaviour Induced by Rat Model of Testicular Torsion: Involvement of Nitric Oxide Pathway

(2015) Seyed Soheil Saeedi Saravi et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Anxiolytic and antidepressant profile of the methanolic extract of Piper nigrum fruits in beta-amyloid (1–42) rat model of Alzheimer’s disease

(2015) Lucian Hritcu et al.   Behavioral and Brain Functions

The Prevalence of Depression in Alzheimer’s Disease: A Systematic Review and Meta-Analysis

(2015) Song Chi et al.   Current Alzheimer Research

On the effect of minocycline on the depressive-like behavior of mice repeatedly exposed to malathion: interaction between nitric oxide and cholinergic system

(2015) Seyed Soheil Saeedi Saravi et al.   METABOLIC BRAIN DISEASE

Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes

(2015) Isabella Caroline da Silva Dias et al.   MOLECULAR NEUROBIOLOGY

Depression as a Microglial Disease

(2015) Raz Yirmiya et al.   TRENDS IN NEUROSCIENCES

Minocycline treatment ameliorates interferon-alpha- induced neurogenic defects and depression-like behaviors in mice

(2015) Lian-Shun Zheng et al.   Frontiers in Cellular Neuroscience

Repeated, high-dose dextromethorphan treatment decreases neurogenesis and results in depression-like behavior in rats

(2015) Kai Ting Po et al.   EXPERIMENTAL BRAIN RESEARCH

Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer’s Disease: a Comparative Overview

(2014) Frederic Brosseron et al.   MOLECULAR NEUROBIOLOGY

Chronic Amitriptyline Treatment Attenuates Nigrostriatal Degeneration and Significantly Alters Trophic Support in a Rat Model of Parkinsonism

(2014) Katrina L Paumier et al.   NEUROPSYCHOPHARMACOLOGY

Antidepressant-like effects of salidroside on olfactory bulbectomy-induced pro-inflammatory cytokine production and hyperactivity of HPA axis in rats

(2014) Shui-Jin Yang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Inhalation of coriander volatile oil increased anxiolytic–antidepressant-like behaviors and decreased oxidative status in beta-amyloid (1–42) rat model of Alzheimer's disease

(2014) Oana Cioanca et al.   PHYSIOLOGY & BEHAVIOR

Fluoxetine exposure during pregnancy and lactation: Effects on acute stress response and behavior in the novelty-suppressed feeding are age and gender-dependent in rats

(2013) José Francis-Oliveira et al.   BEHAVIOURAL BRAIN RESEARCH

Involvement of pGluR1, EAAT2 and EAAT3 in offspring depression induced by prenatal stress

(2013) X.H. Zhang et al.   NEUROSCIENCE

Neurogenesis, inflammation and behavior

(2012) Rachel A. Kohman et al.   BRAIN BEHAVIOR AND IMMUNITY

The immunology of neurodegeneration

(2012) Eva Czirr et al.   JOURNAL OF CLINICAL INVESTIGATION

Minocycline benefits negative symptoms in early schizophrenia: a randomised double-blind placebo-controlled clinical trial in patients on standard treatment

(2012) Imran B Chaudhry et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice

(2012) J H Ledo et al.   MOLECULAR PSYCHIATRY

Minocycline as adjunctive therapy for patients with unipolar psychotic depression: An open-label study

(2012) Tsuyoshi Miyaoka et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Chronic blockade of glucocorticoid receptors by RU486 enhances lipopolysaccharide-induced depressive-like behaviour and cytokine production in rats

(2011) Donglin Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial

(2011) Sube Banerjee et al.   LANCET

Involvement of dorsal hippocampal NMDA-glutamatergic system in anxiety-related behaviors of rats

(2011) J. Solati et al.   Neurochemical Journal

Sertraline for the Treatment of Depression in Alzheimer Disease

(2010) Paul B. Rosenberg et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Sertraline for the Treatment of Depression in Alzheimer Disease: Week-24 Outcomes

(2010) Daniel Weintraub et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

A Meta-Analysis of Cytokines in Alzheimer's Disease

(2010) Walter Swardfager et al.   BIOLOGICAL PSYCHIATRY

Soluble βamyloid1-42: a critical player in producing behavioural and biochemical changes evoking depressive-related state?

(2010) M Colaianna et al.   BRITISH JOURNAL OF PHARMACOLOGY

Depression in Alzheimer's disease: specificity of depressive symptoms using three different clinical criteria

(2010) Knut Engedal et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

The role of microglia in amyloid clearance from the AD brain

(2010) C. Y. Daniel Lee et al.   JOURNAL OF NEURAL TRANSMISSION

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Glucocorticoids, cytokines and brain abnormalities in depression

(2010) Patricia A. Zunszain et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Depression and Alzheimer's disease: Neurobiological links and common pharmacological targets

(2009) Filippo Caraci et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression

(2009) Firdaus S. Dhabhar et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Neuroimmune mechanisms of cytokine-induced depression: Current theories and novel treatment strategies

(2009) Jennifer M. Loftis et al.   NEUROBIOLOGY OF DISEASE

Exacerbated mechanical allodynia in rats with depression-like behavior

(2008) Qing Zeng et al.   BRAIN RESEARCH

Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer’s disease

(2008) M. Filali et al.   GENES BRAIN AND BEHAVIOR

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

(2008) Christopher J Henry et al.   Journal of Neuroinflammation

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

(2008) Michael Maes et al.   METABOLIC BRAIN DISEASE

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

Evaluation of plasma Aβ40 and Aβ42 as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment

(2008) Oskar Hansson et al.   NEUROBIOLOGY OF AGING

Desipramine or glutamate antagonists synergized the antidepressant-like actions of intra-nucleus accumbens infusions of minocycline in male Wistar rats

(2008) Miguel Molina-Hernández et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY