Conformational Characterization and Classification of Intrinsically Disordered Proteins by Native Mass Spectrometry and Charge-State Distribution Analysis

The application of ion-mobility mass spectrometry for structure/function investigation of protein complexes

(2018) Gili Ben-Nissan et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Editorial overview: Omics

(2018) Perdita Barran et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Conformational flexibility within the nascent polypeptide–associated complex enables its interactions with structurally diverse client proteins

(2018) Esther M. Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Structural and Kinetic Characterization of the Intrinsically Disordered Protein SeV NTAIL through Enhanced Sampling Simulations

(2017) Mattia Bernetti et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Proton Dynamics in Protein Mass Spectrometry

(2017) Jinyu Li et al.   Journal of Physical Chemistry Letters

Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo

(2017) Ramona F. Sowade et al.   Nature Communications

Structural disorder and induced folding within two cereal, ABA stress and ripening (ASR) proteins

(2017) Karama Hamdi et al.   Scientific Reports

Disulfide driven folding for a conditionally disordered protein

(2017) Hugo Fraga et al.   Scientific Reports

Opposite Structural Effects of Epigallocatechin-3-gallate and Dopamine Binding to α-Synuclein

(2016) Albert Konijnenberg et al.   ANALYTICAL CHEMISTRY

Distinct Dynamic Modes Enable the Engagement of Dissimilar Ligands in a Promiscuous Atypical RNA Recognition Motif

(2016) Kerene A. Brown et al.   BIOCHEMISTRY

The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules

(2016) Hao Wu et al.   CELL

Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling

(2016) Veronika Csizmok et al.   CHEMICAL REVIEWS

The diverse and expanding role of mass spectrometry in structural and molecular biology

(2016) Philip Lössl et al.   EMBO JOURNAL

Charge-state-distribution analysis of Bach2 intrinsically disordered heme binding region

(2016) Tomoji Suenaga et al.   JOURNAL OF BIOCHEMISTRY

Dancing Protein Clouds: The Strange Biology and Chaotic Physics of Intrinsically Disordered Proteins

(2016) Vladimir N. Uversky   JOURNAL OF BIOLOGICAL CHEMISTRY

Simulation of coupled folding and binding of an intrinsically disordered protein in explicit solvent with metadynamics

(2016) Mengzhi Han et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Are Charge-State Distributions a Reliable Tool Describing Molecular Ensembles of Intrinsically Disordered Proteins by Native MS?

(2016) Antonino Natalello et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Revealing Higher Order Protein Structure Using Mass Spectrometry

(2016) Brian T. Chait et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

ESI-IMS–MS: A method for rapid analysis of protein aggregation and its inhibition by small molecules

(2016) Lydia M. Young et al.   METHODS

Conformational ensemble of human α-synuclein physiological form predicted by molecular simulations

(2016) G. Rossetti et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Consequences of point mutations in melanoma-associated antigen 4 (MAGE-A4) protein: Insights from structural and biophysical studies

(2016) Yoshio Hagiwara et al.   Scientific Reports

Influence of Ammonium Acetate Concentration on Receptor–Ligand Binding Affinities Measured by Native Nano ESI-MS: A Systematic Study

(2015) Agni F. M. Gavriilidou et al.   ANALYTICAL CHEMISTRY

Heme binds to an intrinsically disordered region of Bach2 and alters its conformation

(2015) Miki Watanabe-Matsui et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Functional roles of transiently and intrinsically disordered regions within proteins

(2015) Vladimir N. Uversky   FEBS Journal

Ensemble Methods Enable a New Definition for the Solution to Gas-Phase Transfer of Intrinsically Disordered Proteins

(2015) Antoni J. Borysik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Release of Native-like Gaseous Proteins from Electrospray Droplets via the Charged Residue Mechanism: Insights from Molecular Dynamics Simulations

(2015) Robert G. McAllister et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conformational effects in protein electrospray-ionization mass spectrometry

(2015) Jinyu Li et al.   MASS SPECTROMETRY REVIEWS

Probabilistic calculations of biomolecule charge states that generate mass spectra of multiply charged ions

(2015) M. O. Raznikova et al.   MOLECULAR BIOLOGY

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The emerging role of native mass spectrometry in characterizing the structure and dynamics of macromolecular complexes

(2015) Elisabetta Boeri Erba et al.   PROTEIN SCIENCE

Introducing Protein Intrinsic Disorder

(2014) Johnny Habchi et al.   CHEMICAL REVIEWS

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

The Mitochondrial Intermembrane Space Oxireductase Mia40 Funnels the Oxidative Folding Pathway of the CytochromecOxidase Assembly Protein Cox19

(2014) Hugo Fraga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis for Structural Heterogeneity of an Intrinsically Disordered Protein Bound to a Partner by Combined ESI-IM-MS and Modeling

(2014) Annalisa D’Urzo et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics

(2014) Francesco Lanucara et al.   Nature Chemistry

Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry

(2014) Lydia M. Young et al.   Nature Chemistry

Status of Large-scale Analysis of Post-translational Modifications by Mass Spectrometry

(2013) Jesper V. Olsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Mass spectrometry-based methods to study protein architecture and dynamics

(2013) Igor A. Kaltashov et al.   PROTEIN SCIENCE

Unusual biophysics of intrinsically disordered proteins

(2012) Vladimir N. Uversky   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Flexible-meccano: a tool for the generation of explicit ensemble descriptions of intrinsically disordered proteins and their associated experimental observables

(2012) V. Ozenne et al.   BIOINFORMATICS

A Computational Model for Protein Ionization by Electrospray Based on Gas-Phase Basicity

(2012) Roberto Marchese et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Intramolecular interactions stabilizing compact conformations of the intrinsically disordered kinase-inhibitor domain of Sic1: a molecular dynamics investigation

(2012) Matteo Lambrughi et al.   Frontiers in Physiology

Charge-Surface Correlation in Electrospray Ionization of Folded and Unfolded Proteins

(2011) Lorenzo Testa et al.   ANALYTICAL CHEMISTRY

Folding and misfolding of alpha-synuclein on membranes

(2011) Igor Dikiy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Compaction Properties of an Intrinsically Disordered Protein: Sic1 and Its Kinase-Inhibitor Domain

(2011) Stefania Brocca et al.   BIOPHYSICAL JOURNAL

Intrinsically disordered proteins: regulation and disease

(2011) M Madan Babu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Characterization of β2-microglobulin conformational intermediates associated to different fibrillation conditions

(2011) Carlo Santambrogio et al.   JOURNAL OF MASS SPECTROMETRY

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

(2011) Jiyong Lee et al.   Nature Chemical Biology

Relative Solvent Accessible Surface Area Predicts Protein Conformational Changes upon Binding

(2011) Joseph A. Marsh et al.   STRUCTURE

Sequence Determinants of Compaction in Intrinsically Disordered Proteins

(2010) Joseph A. Marsh et al.   BIOPHYSICAL JOURNAL

Compact conformations of α-synuclein induced by alcohols and copper

(2010) Antonino Natalello et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The Meandering of Disordered Proteins in Conformational Space

(2010) Robert Konrat   STRUCTURE

On the Zwitterionic Nature of Gas-Phase Peptides and Protein Ions

(2010) Roberto Marchese et al.   PLoS Computational Biology

Electrospray-ionization mass spectrometry as a tool for fast screening of protein structural properties

(2009) Rita Grandori et al.   Biotechnology Journal

Unfoldomics of human diseases: linking protein intrinsic disorder with diseases

(2009) Vladimir N Uversky et al.   BMC GENOMICS

Decomposition of Charge-State Distributions for a Better Understanding of Electrospray Mass Spectra of Bioorganic Compounds. Part 1: Basic Formalism

(2009) Valeriy V. Raznikov et al.   EUROPEAN JOURNAL OF MASS SPECTROMETRY

Order propensity of an intrinsically disordered protein, the cyclin-dependent-kinase inhibitor Sic1

(2009) Stefania Brocca et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

α-Synuclein Misfolding and Neurodegenerative Diseases

(2008) Vladimir Uversky   CURRENT PROTEIN & PEPTIDE SCIENCE