Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome

Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT7 receptor

(2014) Enza Lacivita et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor

(2014) Hanne D. Hansen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism

(2014) Simona D’Antoni et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

5-HT7 receptor activation: procognitive and antiamnesic effects

(2014) A. Meneses et al.   PSYCHOPHARMACOLOGY

Serotonergic 5-HT7 receptors and cognition

(2014) Antonella Gasbarri et al.   REVIEWS IN THE NEUROSCIENCES

5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders

(2014) Lucia Ciranna et al.   Frontiers in Cellular Neuroscience

The serotonin receptor 7 and the structural plasticity of brain circuits

(2014) Floriana Volpicelli et al.   Frontiers in Behavioral Neuroscience

Systemic administration and local microinjection into the central nervous system of the 5-HT7 receptor agonist LP-211 modify the sleep-wake cycle in the rat

(2013) Jaime M. Monti et al.   BEHAVIOURAL BRAIN RESEARCH

Modulation of 5-HT7 receptor: effect on object recognition performances in mice

(2013) Thomas Freret et al.   PSYCHOPHARMACOLOGY

The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)

(2012) Asha L. Bhakar et al.   Annual Review of Neuroscience

Lifting the Mood on Treating Fragile X

(2012) Emily K. Osterweil et al.   BIOLOGICAL PSYCHIATRY

Activation of 5-HT7 Serotonin Receptors Reverses Metabotropic Glutamate Receptor-Mediated Synaptic Plasticity in Wild-Type and Fmr1 Knockout Mice, a Model of Fragile X Syndrome

(2012) Lara Costa et al.   BIOLOGICAL PSYCHIATRY

Investigations on the 1-(2-Biphenyl)piperazine Motif: Identification of New Potent and Selective Ligands for the Serotonin7 (5-HT7) Receptor with Agonist or Antagonist Action in Vitro or ex Vivo

(2012) Enza Lacivita et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Modifications that Alter the P-Glycoprotein Efflux Properties of Compounds

(2012) Stephen A. Hitchcock   JOURNAL OF MEDICINAL CHEMISTRY

Discrimination learning and attentional set formation in a mouse model of Fragile X.

(2011) Kimberly S. Casten et al.   BEHAVIORAL NEUROSCIENCE

5-HT1A and 5-HT7 receptors differently modulate AMPA receptor-mediated hippocampal synaptic transmission

(2011) L. Costa et al.   HIPPOCAMPUS

Role of the 5-HT7 Receptor in the Central Nervous System: from Current Status to Future Perspectives

(2011) Anne Matthys et al.   MOLECULAR NEUROBIOLOGY

Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice

(2011) Walter Adriani et al.   NEUROPHARMACOLOGY

Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome

(2011) D. D. Krueger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological reversal of synaptic plasticity deficits in the mouse model of Fragile X syndrome by group II mGluR antagonist or lithium treatment

(2010) Catherine H. Choi et al.   BRAIN RESEARCH

Long-term depression in the CNS

(2010) Graham L. Collingridge et al.   NATURE REVIEWS NEUROSCIENCE

Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease

(2010) Christian Lüscher et al.   NEURON

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor

(2010) Peter B. Hedlund et al.   NEUROSCIENCE LETTERS

The 5-HT7 receptor is involved in allocentric spatial memory information processing

(2009) Gor Sarkisyan et al.   BEHAVIOURAL BRAIN RESEARCH

Altered Hippocampal Synaptic Plasticity in the Fmr1 Gene Family Knockout Mouse Models

(2009) Jing Zhang et al.   JOURNAL OF NEUROPHYSIOLOGY

A Novel Function for Fragile X Mental Retardation Protein in Translational Activation

(2009) Elias G Bechara et al.   PLOS BIOLOGY

Molecular biology of 5-HT receptors

(2008) Jason Hannon et al.   BEHAVIOURAL BRAIN RESEARCH

Serotonin Receptors

(2008) David E. Nichols et al.   CHEMICAL REVIEWS

Fragile X syndrome

(2008) Kathryn B Garber et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

5-HT7 receptor stimulation by 8-OH-DPAT counteracts the impairing effect of 5-HT1A receptor stimulation on contextual learning in mice

(2008) Therese M. Eriksson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Structural Modifications ofN-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-Aryl-1-piperazinehexanamides: Influence on Lipophilicity and 5-HT7Receptor Activity. Part III

(2008) Marcello Leopoldo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Executive functions in young males with fragile X syndrome in comparison to mental age-matched controls: Baseline findings from a longitudinal study.

(2008) Stephen R. Hooper et al.   NEUROPSYCHOLOGY