DHS (trans−4,4′-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2)

Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance

(2018) Wei Zhou et al.   ONCOGENE

The synergistic effect of resveratrol in combination with cisplatin on apoptosis via modulating autophagy in A549 cells

(2016) Song Hu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Diagnostic Microdosing Approach to Study Gemcitabine Resistance

(2016) Tiffany M. Scharadin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Targeting DNA Replication Stress for Cancer Therapy

(2016) Jun Zhang et al.   Genes

A Potent Derivative of Indolizino[6,7-b]Indole for Treatment of Human Non–Small Cell Lung Cancer Cells

(2016) Chi-Wei Chen et al.   NEOPLASIA

Resveratrol analogue 4,4′-dihydroxy-trans-stilbene potently inhibits cancer invasion and metastasis

(2016) Monica Savio et al.   Scientific Reports

Determination of naturally occurring resveratrol analog trans-4,4′-dihydroxystilbene in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study

(2015) Wan Chen et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Targeting DNA repair, DNA metabolism and replication stress as anti-cancer strategies

(2015) Jordi Carreras Puigvert et al.   FEBS Journal

IncreasedRrm2gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

(2015) Andres J. Lopez-Contreras et al.   GENES & DEVELOPMENT

Resveratrol enhanced anticancer effects of cisplatin on non-small cell lung cancer cell lines by inducing mitochondrial dysfunction and cell apoptosis

(2015) LIJIE MA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Ribonucleotide reductase is an effective target to overcome gemcitabine resistance in gemcitabine-resistant pancreatic cancer cells with dual resistant factors

(2015) Kentaro Minami et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications

(2015) Rebecca Kohnken et al.   Molecular Cancer

Targeting Ribonucleotide Reductase M2 and NF- B Activation with Didox to Circumvent Tamoxifen Resistance in Breast Cancer

(2015) K. N. Shah et al.   MOLECULAR CANCER THERAPEUTICS

Targeting the DNA Damage Response in Cancer

(2015) Mark J. O’Connor   MOLECULAR CELL

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies

(2014) Y Aye et al.   ONCOGENE

A Small-Molecule Blocking Ribonucleotide Reductase Holoenzyme Formation Inhibits Cancer Cell Growth and Overcomes Drug Resistance

(2013) B. Zhou et al.   CANCER RESEARCH

AKT-Induced Tamoxifen Resistance Is Overturned by RRM2 Inhibition

(2013) Khyati N. Shah et al.   MOLECULAR CANCER RESEARCH

Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a synthetic resveratrol analogue

(2013) Hanna Piotrowska et al.   TOXICOLOGY IN VITRO

DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells

(2012) Yuriko Saiki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dietary Resveratrol Prevents Development of High-Grade Prostatic Intraepithelial Neoplastic Lesions: Involvement of SIRT1/S6K Axis

(2012) G. Li et al.   Cancer Prevention Research

The resveratrol analog 4,4'-dihydroxy-trans-stilbene suppresses transformation in normal mouse fibroblasts and inhibits proliferation and invasion of human breast cancer cells

(2012) C. Maccario et al.   CARCINOGENESIS

Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair

(2012) Vincenzo D'Angiolella et al.   CELL

Ribonucleotide reductase small subunit M2 serves as a prognostic biomarker and predicts poor survival of colorectal cancers

(2012) Xiyong Liu et al.   CLINICAL SCIENCE

A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol

(2012) Melanie Gertz et al.   PLoS One

Resveratrol analogue 3,4,4′,5-tetramethoxystilbene inhibits growth, arrests cell cycle and induces apoptosis in ovarian SKOV‐3 and A-2780 cancer cells

(2012) Hanna Piotrowska et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Emerging roles of the ribonucleotide reductase M2 in colorectal cancer and ultraviolet-induced DNA damage repair

(2012) Ai-Guo Lu   WORLD JOURNAL OF GASTROENTEROLOGY

Resveratrol-Containing Gel for the Treatment of Acne Vulgaris

(2011) Gabriella Fabbrocini et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Modulation of the ribonucleotide reductase M1–gemcitabine interaction in vivo by N-ethylmaleimide

(2011) Zhengming Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis

(2010) V. A. Brown et al.   CANCER RESEARCH

Ribonucleotide reductase M2 subunit is a novel diagnostic marker and a potential therapeutic target in bladder cancer

(2010) Teppei Morikawa et al.   HISTOPATHOLOGY

Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro

(2010) Teppei Morikawa et al.   HUMAN PATHOLOGY

4,4′-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity

(2009) Gui-Juan Fan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Application of the PM6 semi-empirical method to modeling proteins enhances docking accuracy of AutoDock

(2009) Zsolt Bikadi et al.   Journal of Cheminformatics

Antitumor and antimetastatic actions of anthrone-C-glucoside, cassialoin isolated from Cassia garrettiana heartwood in colon 26-bearing mice

(2008) Yoshiyuki Kimura et al.   CANCER SCIENCE