Beyond the bone: Bone morphogenetic protein signaling in adipose tissue

Role of Human Brown Fat in Obesity, Metabolism and Cardiovascular Disease: Strategies to Turn Up the Heat

(2018) Jonatan R. Ruiz et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues

(2017) Rajan Singh et al.   ENDOCRINOLOGY

Overexpression of bone morphogenetic protein-3b (BMP-3b) in adipose tissues protects against high-fat diet-induced obesity

(2017) J Hino et al.   INTERNATIONAL JOURNAL OF OBESITY

The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice

(2017) Abdul Soofi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The significance of beige and brown fat in humans

(2017) Florian W Kiefer   Endocrine Connections

Analysis of long noncoding RNA and mRNA using RNA sequencing during the differentiation of intramuscular preadipocytes in chicken

(2017) Tao Zhang et al.   PLoS One

BMPs as new insulin sensitizers: enhanced glucose uptake in mature 3T3-L1 adipocytes via PPARγ and GLUT4 upregulation

(2017) Isabelle Schreiber et al.   Scientific Reports

Structure of Gremlin-1 and analysis of its interaction with BMP-2

(2016) M. Ki onaite et al.   BIOCHEMICAL JOURNAL

Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program

(2016) Mengle Shao et al.   Cell Metabolism

miR-375 negatively regulates porcine preadipocyte differentiation by targeting BMPR2

(2016) Siyuan Liu et al.   FEBS LETTERS

Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes

(2016) X Ge et al.   INTERNATIONAL JOURNAL OF OBESITY

Trends in Obesity Among Adults in the United States, 2005 to 2014

(2016) Katherine M. Flegal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cell biology of fat storage

(2016) Paul Cohen et al.   MOLECULAR BIOLOGY OF THE CELL

BMP signalling in skeletal development, disease and repair

(2016) Valerie S. Salazar et al.   Nature Reviews Endocrinology

Ahnak stimulates BMP2-mediated adipocyte differentiation through Smad1 activation

(2016) Sunmee Shin et al.   Obesity

Bone morphogenetic protein 2 (BMP2 ) may contribute to partition of energy storage into visceral and subcutaneous fat depots

(2016) Esther Guiu-Jurado et al.   Obesity

BMP4 mediates the interplay between adipogenesis and angiogenesis during expansion of subcutaneous white adipose tissue

(2016) Yan Tang et al.   Journal of Molecular Cell Biology

TGFβ-induced switch from adipogenic to osteogenic differentiation of human mesenchymal stem cells: identification of drug targets for prevention of fat cell differentiation

(2016) Everardus J. van Zoelen et al.   Stem Cell Research & Therapy

Bmp4 Promotes a Brown to White-like Adipocyte Shift

(2016) Salvatore Modica et al.   Cell Reports

EBF2 promotes the recruitment of beige adipocytes in white adipose tissue

(2016) Rachel R. Stine et al.   Molecular Metabolism

BMP4 Cross-talks With Estrogen/ERα Signaling to Regulate Adiposity and Glucose Metabolism in Females

(2016) Shu-wen Qian et al.   EBioMedicine

BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis

(2015) Birgit Gustafson et al.   DIABETES

Osteoporosis-associated alteration in the signalling status of BMP-2 in human MSCs under adipogenic conditions

(2015) Oscar Donoso et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effect of Diabetes Mellitus on Adipocyte-Derived Stem Cells in Rat

(2015) Medet Jumabay et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Gremlin 2 inhibits adipocyte differentiation through activation of Wnt/β-catenin signaling

(2015) QING WU et al.   Molecular Medicine Reports

Targeting BMP signalling in cardiovascular disease and anaemia

(2015) Nicholas W. Morrell et al.   Nature Reviews Cardiology

BMP gradients: A paradigm for morphogen-mediated developmental patterning

(2015) E. Bier et al.   SCIENCE

Adipokines in health and disease

(2015) Mathias Fasshauer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Bone Morphogenetic Protein-2 Induces Donor-Dependent Osteogenic and Adipogenic Differentiation in Human Adipose Stem Cells

(2015) Sari Vanhatupa et al.   Stem Cells Translational Medicine

Estrogens increase expression of bone morphogenetic protein 8b in brown adipose tissue of mice

(2015) Aldo Grefhorst et al.   Biology of Sex Differences

Inhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix Gla Protein Deficiency

(2015) Rajeev Malhotra et al.   PLoS One

Dynamic profile and adipogenic role of growth differentiation factor 5 (GDF5) in the differentiation of 3T3-L1 preadipocytes

(2014) Zhou Pei et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Bone Morphogenetic Proteins: Structure, biological function and therapeutic applications

(2014) Ana Claudia Carreira et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

BMP and activin membrane-bound inhibitor (BAMBI) inhibits the adipogenesis of porcine preadipocytes through Wnt/β-catenin signaling pathway

(2014) Yin Mai et al.   Biochemistry and Cell Biology

BMP2 Increases Adipogenic Differentiation in the Presence of Dexamethasone, which is Inhibited by the Treatment of TNF-a in Human Adipose Tissue-Derived Stromal Cells

(2014) Sun Young Lee et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Follistatin promotes adipocyte differentiation, browning, and energy metabolism

(2014) Melissa Braga et al.   JOURNAL OF LIPID RESEARCH

BMP7 Drives Human Adipogenic Stem Cells into Metabolically Active Beige Adipocytes

(2014) Meshail Okla et al.   LIPIDS

Brown Fat Determination and Development from Muscle Precursor Cells by Novel Action of Bone Morphogenetic Protein 6

(2014) Ankur Sharma et al.   PLoS One

Insulin-Like Growth Factor-1 and Bone Morphogenetic Protein-2 Jointly Mediate Prostaglandin E2-Induced Adipogenic Differentiation of Rat Tendon Stem Cells

(2014) Junpeng Liu et al.   PLoS One

Ebf2 is a selective marker of brown and beige adipogenic precursor cells

(2014) Wenshan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGFβ and BMP signaling in skeletal muscle: potential significance for muscle-related disease

(2014) Roberta Sartori et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Characterization of Cre recombinase models for the study of adipose tissue

(2014) Elise Jeffery et al.   Adipocyte

BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells

(2013) Manuela Elsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes

(2013) Ruidan Xue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis

(2013) Shingo Kajimura et al.   Annual Review of Physiology

EBF2 Determines and Maintains Brown Adipocyte Identity

(2013) Sona Rajakumari et al.   Cell Metabolism

A Role for the Endothelium in Vascular Calcification

(2013) Yucheng Yao et al.   CIRCULATION RESEARCH

Bmp4 expressed in preadipocytes is required for the onset of adipocyte differentiation

(2013) Masashi Suenaga et al.   CYTOKINE

Growth Differentiation Factor-5 Promotes Brown Adipogenesis in Systemic Energy Expenditure

(2013) E. Hinoi et al.   DIABETES

Lessons on Conditional Gene Targeting in Mouse Adipose Tissue

(2013) K. Y. Lee et al.   DIABETES

Addition of bone morphogenetic protein type 2 to ascorbate and β-glycerophosphate supplementation did not enhance osteogenic differentiation of human adipose-derived stem cells

(2013) Ariadne Cristiane Cabral Cruz et al.   Journal of Applied Oral Science

Follistatin-Like 1: A Potential Mediator of Inflammation in Obesity

(2013) Nengguang Fan et al.   MEDIATORS OF INFLAMMATION

Cell-Autonomous Regulation of Brown Fat Identity GeneUCP1by Unliganded Vitamin D Receptor

(2013) Peter J. Malloy et al.   MOLECULAR ENDOCRINOLOGY

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

(2013) Tim J. Schulz et al.   NATURE

Inhibition of in vitro and in vivo brown fat differentiation program by myostatin

(2013) Melissa Braga et al.   Obesity

BMP signaling and its modifiers in kidney development

(2013) Ryuichi Nishinakamura et al.   PEDIATRIC NEPHROLOGY

BMP7 Activates Brown Adipose Tissue and Reduces Diet-Induced Obesity Only at Subthermoneutrality

(2013) Mariëtte R. Boon et al.   PLoS One

BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis

(2013) Shu-Wen Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BMP-Smad 1/5/8 signalling in the development of the nervous system

(2013) Shane V. Hegarty et al.   PROGRESS IN NEUROBIOLOGY

Adipogenesis: From Stem Cell to Adipocyte

(2012) Qi Qun Tang et al.   Annual Review of Biochemistry

Increased Mitochondrial Activity in BMP7-Treated Brown Adipocytes, Due to Increased CPT1- and CD36-Mediated Fatty Acid Uptake

(2012) Kristy L. Townsend et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus

(2012) Letícia de Almeida Brondani et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

(2012) Andrew J. Whittle et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular Cells

(2012) Rana K. Gupta et al.   Cell Metabolism

The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in Humans

(2012) Birgit Gustafson et al.   DIABETES

Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway

(2012) Kristy L. Townsend et al.   FASEB JOURNAL

Noggin Is Novel Inducer of Mesenchymal Stem Cell Adipogenesis

(2012) Anandi Sawant et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism

(2012) B. Fournier et al.   MOLECULAR AND CELLULAR BIOLOGY

Using Gene Expression to Predict Differences in the Secretome of Human Omental vs. Subcutaneous Adipose Tissue

(2012) Nigel Hoggard et al.   Obesity

The adipose organ: white-brown adipocyte plasticity and metabolic inflammation

(2012) A. Smorlesi et al.   Obesity Reviews

Manipulating molecular switches in brown adipocytes and their precursors: A therapeutic potential

(2012) Aybike Birerdinc et al.   PROGRESS IN LIPID RESEARCH

Transient Brown Adipocyte-Like Cells Derive from Peripheral Nerve Progenitors in Response to Bone Morphogenetic Protein 2

(2012) Elizabeth A. Salisbury et al.   Stem Cells Translational Medicine

Brown adipose tissue

(2012) Kristy Townsend et al.   Adipocyte

Identification of BMP and Activin Membrane-Bound Inhibitor (BAMBI) as a Potent Negative Regulator of Adipogenesis and Modulator of Autocrine/Paracrine Adipogenic Factors

(2011) X. Luo et al.   DIABETES

Noggin

(2011) Carola Krause et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Bone morphogenetic protein-3b (BMP-3b) is expressed in adipocytes and inhibits adipogenesis as a unique complex

(2011) J Hino et al.   INTERNATIONAL JOURNAL OF OBESITY

Matrix Gla protein deficiency causes arteriovenous malformations in mice

(2011) Yucheng Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Follistatin and Follistatin Like-3 Differentially Regulate Adiposity and Glucose Homeostasis

(2011) Melissa L. Brown et al.   Obesity

Genetic and Evolutionary Analyses of the Human Bone Morphogenetic Protein Receptor 2 (BMPR2) in the Pathophysiology of Obesity

(2011) Dorit Schleinitz et al.   PLoS One

TGF-β superfamily regulates a switch that mediates differentiation either into adipocytes or myocytes in left atrium derived pluripotent cells (LA-PCS)

(2010) Nanako Kawaguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of Vascular Bone Morphogenetic Protein Signaling in Diabetes Mellitus

(2010) Kristina I. Boström et al.   CIRCULATION RESEARCH

Adipose-derived Stem cells and BMP2: Part 2. BMP2 may not influence the osteogenic fate of human adipose-derived stem cells

(2010) Patricia Zuk et al.   CONNECTIVE TISSUE RESEARCH

Downregulated expression of the secreted glycoprotein follistatin-like 1 (Fstl1) is a robust hallmark of preadipocyte to adipocyte conversion

(2010) Yu Wu et al.   MECHANISMS OF DEVELOPMENT

Cross Talk between Insulin and Bone Morphogenetic Protein Signaling Systems in Brown Adipogenesis

(2010) H. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Human Adipose-Derived Stromal Cells Respond to and Elaborate Bone Morphogenetic Protein-2 during In Vitro Osteogenic Differentiation

(2010) Nicholas J. Panetta et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

New insights into bone morphogenetic protein signaling: focus on angiogenesis

(2009) Isabel Moreno-Miralles et al.   CURRENT OPINION IN HEMATOLOGY

BMP-6 and mesenchymal stem cell differentiation

(2009) Slobodan Vukicevic et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Adipose Tissue Expression and Genetic Variants of the Bone Morphogenetic Protein Receptor 1A Gene (BMPR1A) Are Associated With Human Obesity

(2009) Y. Bottcher et al.   DIABETES

Using gene expression to predict the secretome of differentiating human preadipocytes

(2009) D M Mutch et al.   INTERNATIONAL JOURNAL OF OBESITY

Role of Follistatin in Promoting Adipogenesis in Women

(2009) John N. Flanagan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Combinatorial Gene Therapy with BMP2/7 Enhances Cranial Bone Regeneration

(2009) J.T. Koh et al.   JOURNAL OF DENTAL RESEARCH

Myostatin Inhibition in Muscle, but Not Adipose Tissue, Decreases Fat Mass and Improves Insulin Sensitivity

(2009) Tingqing Guo et al.   PLoS One

BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage

(2009) H. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global burden of obesity in 2005 and projections to 2030

(2008) T Kelly et al.   INTERNATIONAL JOURNAL OF OBESITY

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE

Will All Americans Become Overweight or Obese? Estimating the Progression and Cost of the US Obesity Epidemic

(2008) Youfa Wang et al.   Obesity

Focus on Molecules: Gremlin

(2007) Robert J. Wordinger et al.   EXPERIMENTAL EYE RESEARCH