Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

Insights into Cytokine–Receptor Interactions from Cytokine Engineering

(2015) Jamie B. Spangler et al.   Annual Review of Immunology

Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands

(2015) Ignacio Moraga et al.   CELL

Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps

(2015) Suman Mitra et al.   IMMUNITY

Multifaceted Activities of Type I Interferon Are Revealed by a Receptor Antagonist

(2014) D. Levin et al.   Science Signaling

Concise Review: Engineering the Fusion of Cytokines for the Modulation of Immune Cellular Responses in Cancer and Autoimmune Disorders

(2014) Spencer Ng et al.   Stem Cells Translational Medicine

STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor

(2013) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function

(2012) M. P. Gil et al.   BLOOD

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

(2012) John J. O'Shea et al.   IMMUNITY

The Extracellular and Transmembrane Domains of the γC and Interleukin (IL)-13 Receptor α1 Chains, Not Their Cytoplasmic Domains, Dictate the Nature of Signaling Responses to IL-4 and IL-13

(2012) Nicola M. Heller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

(2012) Aron M. Levin et al.   NATURE

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines

(2012) Ilkka S Junttila et al.   Nature Chemical Biology

Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

(2011) Christoph Thomas et al.   CELL

Interpreting mixed signals: the cell's cytokine conundrum

(2011) Greg M Delgoffe et al.   CURRENT OPINION IN IMMUNOLOGY

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Major Differences in the Responses of Primary Human Leukocyte Subsets to IFN- 

(2010) A. H. H. van Boxel-Dezaire et al.   JOURNAL OF IMMUNOLOGY

Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon

(2009) T. Greenwell-Wild et al.   BLOOD

Receptor Density Is Key to the Alpha2/Beta Interferon Differential Activities

(2009) I. Moraga et al.   MOLECULAR AND CELLULAR BIOLOGY

A granulocyte-macrophage colony–stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with immune suppressive properties

(2009) Moutih Rafei et al.   NATURE MEDICINE

Structural Biology of Shared Cytokine Receptors

(2007) Xinquan Wang et al.   Annual Review of Immunology