Deuterated Arachidonic Acids Library for Regulation of Inflammation and Controlled Synthesis of Eicosanoids: An In Vitro Study

Astrocytes synthesize primary and cyclopentenone prostaglandins that are negative regulators of their proliferation

(2018) Dmitry V. Chistyakov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Randomized, clinical trial of RT001: Early signals of efficacy in Friedreich's ataxia

(2018) Theresa Zesiewicz et al.   MOVEMENT DISORDERS

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Lipidomics Reveals Dramatic Physiological Kinetic Isotope Effects during the Enzymatic Oxygenation of Polyunsaturated Fatty Acids Ex Vivo

(2017) Aaron R. Navratil et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetic investigation of human 5-lipoxygenase with arachidonic acid

(2016) Monica Mittal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Understanding the Mechanism of the Hydrogen Abstraction from Arachidonic Acid Catalyzed by the Human Enzyme 15-Lipoxygenase-2. A Quantum Mechanics/Molecular Mechanics Free Energy Simulation

(2016) Reynier Suardíaz et al.   Journal of Chemical Theory and Computation

Resolution of Inflammation: What Controls Its Onset?

(2016) Michelle A. Sugimoto et al.   Frontiers in Immunology

Full Library of (Bis-allyl)-deuterated Arachidonic Acids: Synthesis and Analytical Verification

(2016) Maksim A. Fomich et al.   ChemistrySelect

Cyclooxygenase inhibitors: From pharmacology to clinical read-outs

(2015) Paola Patrignani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mammalian lipoxygenases and their biological relevance

(2015) Hartmut Kuhn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid

(2015) William S. Powell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

(2015) Olof Rådmark et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Isotope-reinforced polyunsaturated fatty acids protect mitochondria from oxidative stress

(2015) Alexander Y. Andreyev et al.   FREE RADICAL BIOLOGY AND MEDICINE

12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain

(2015) Li Sun et al.   JOURNAL OF LIPID RESEARCH

New insights into the resolution of inflammation

(2015) Derek Gilroy et al.   SEMINARS IN IMMUNOLOGY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Transcellular biosynthesis of eicosanoids

(2014) Angelo Sala et al.   Pharmacological Reports

Recent Advances in the Search for Novel 5-Lipoxygenase Inhibitors

(2013) Dieter Steinhilber et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation

(2012) Shauna Hill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects

(2010) Gang Wu et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Prostaglandin H synthase: Resolved and unresolved mechanistic issues

(2009) Ah-Lim Tsai et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Kinetic and Structural Investigations of the Allosteric Site in Human Epithelial 15-Lipoxygenase-2

(2009) Aaron T. Wecksler et al.   BIOCHEMISTRY

New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development

(2008) Juan J. Moreno   BIOCHEMICAL PHARMACOLOGY