Realizing the Promise of Reverse Phase Protein Arrays for Clinical, Translational, and Basic Research: A Workshop Report

The Heme Degradation Pathway is a Promising Serum Biomarker Source for the Early Detection of Alzheimer's Disease

(2017) Claudius Mueller et al.   JOURNAL OF ALZHEIMERS DISEASE

Evaluation of reverse phase protein array (RPPA)-based pathway-activation profiling in 84 non-small cell lung cancer (NSCLC) cell lines as platform for cancer proteomics and biomarker discovery

(2013) Ramesh Ummanni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Glioblastoma Cell Enrichment Is Critical for Analysis of Phosphorylated Drug Targets and Proteomic-Genomic Correlations

(2013) C. Mueller et al.   CANCER RESEARCH

Neuregulin Autocrine Signaling Promotes Self-Renewal of Breast Tumor-Initiating Cells by Triggering HER2/HER3 Activation

(2013) C. Y.-F. Lee et al.   CANCER RESEARCH

Proteomic Markers of DNA Repair and PI3K Pathway Activation Predict Response to the PARP Inhibitor BMN 673 in Small Cell Lung Cancer

(2013) R. J. Cardnell et al.   CLINICAL CANCER RESEARCH

Systems Analysis of the NCI-60 Cancer Cell Lines by Alignment of Protein Pathway Activation Modules with “-OMIC” Data Fields and Therapeutic Response Signatures

(2013) Giulia Federici et al.   MOLECULAR CANCER RESEARCH

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

(2012) Michael J. Lee et al.   CELL

Molecular Analysis of HER2 Signaling in Human Breast Cancer by Functional Protein Pathway Activation Mapping

(2012) J. D. Wulfkuhle et al.   CLINICAL CANCER RESEARCH

Combining imaging and pathway profiling: an alternative approach to cancer drug discovery

(2012) Neil O. Carragher et al.   DRUG DISCOVERY TODAY

Antibody validation by combining immunohistochemistry and protein extraction from formalin-fixed paraffin-embedded tissues

(2012) Claudia Schuster et al.   HISTOPATHOLOGY

Modern Phenotypic Drug Discovery Is a Viable, Neoclassic Pharma Strategy

(2012) Jonathan A. Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Pilot Characterization of Human Lung NSCLC by Protein Pathway Activation Mapping

(2012) Angela Zupa et al.   Journal of Thoracic Oncology

Triplex DNA-binding proteins are associated with clinical outcomes revealed by proteomic measurements in patients with colorectal cancer

(2012) Laura D Nelson et al.   Molecular Cancer

Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer

(2012) Stefan Uhlmann et al.   Molecular Systems Biology

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

The UCSC Cancer Genomics Browser: update 2013

(2012) Mary Goldman et al.   NUCLEIC ACIDS RESEARCH

NormaCurve: A SuperCurve-Based Method That Simultaneously Quantifies and Normalizes Reverse Phase Protein Array Data

(2012) Sylvie Troncale et al.   PLoS One

Antibody-free, targeted mass-spectrometric approach for quantification of proteins at low picogram per milliliter levels in human plasma/serum

(2012) T. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An efficient procedure for protein extraction from formalin-fixed, paraffin-embedded tissues for reverse phase protein arrays

(2012) Huifang Guo et al.   Proteome Science

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Strong EGFR signaling in cell line models of ERBB2-amplified breast cancer attenuates response towards ERBB2-targeting drugs

(2012) F Henjes et al.   Oncogenesis

Curcumin Treatment Suppresses IKKβ Kinase Activity of Salivary Cells of Patients with Head and Neck Cancer: A Pilot Study

(2011) Suejung G. Kim et al.   CLINICAL CANCER RESEARCH

Advancing cancer drug discovery towards more agile development of targeted combination therapies

(2011) Neil O Carragher et al.   Future Medicinal Chemistry

Protein Pathway Activation Mapping of Brain Metastasis from Lung and Breast Cancers Reveals Organ Type Specific Drug Target Activation

(2011) Giuseppina Improta et al.   JOURNAL OF PROTEOME RESEARCH

High Resolution Mapping of the Cardiac Transmural Proteome Using Reverse Phase Protein Microarrays

(2011) Troy Anderson et al.   MOLECULAR & CELLULAR PROTEOMICS

Lysate Microarrays Enable High-throughput, Quantitative Investigations of Cellular Signaling

(2011) Mark Sevecka et al.   MOLECULAR & CELLULAR PROTEOMICS

A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease

(2011) Terri A Addona et al.   NATURE BIOTECHNOLOGY

A roadmap to generate renewable protein binders to the human proteome

(2011) Karen Colwill et al.   NATURE METHODS

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling

(2011) Y Lu et al.   ONCOGENE

One-Step Preservation of Phosphoproteins and Tissue Morphology at Room Temperature for Diagnostic and Research Specimens

(2011) Claudius Mueller et al.   PLoS One

RNAi-based validation of antibodies for reverse phase protein arrays

(2011) Heiko A Mannsperger et al.   Proteome Science

Elevated expression levels of ANXA11, integrins β3 and α3, and TNF-α contribute to a candidate proteomic signature in urine for kidney allograft rejection

(2011) Meera Srivastava et al.   Proteomics Clinical Applications

Development of miniaturized immunoassay: Influence of surface chemistry and comparison with enzyme-linked immunosorbent assay and Western blot

(2010) Graziella El Khoury et al.   ANALYTICAL BIOCHEMISTRY

RPPanalyzer: Analysis of reverse-phase protein array data

(2010) Heiko A. Mannsperger et al.   BIOINFORMATICS

Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM

(2010) Charles J. Vaske et al.   BIOINFORMATICS

A novel biomarker harvesting nanotechnology identifies Bak as a candidate melanoma biomarker in serum

(2010) Caterina Longo et al.   EXPERIMENTAL DERMATOLOGY

Protein pathway biomarker analysis of human cancer reveals requirement for upfront cellular-enrichment processing

(2010) Alessandra Silvestri et al.   LABORATORY INVESTIGATION

Reverse phase protein microarrays advance to use in clinical trials

(2010) Claudius Mueller et al.   Molecular Oncology

Systems analysis of EGF receptor signaling dynamics with microwestern arrays

(2010) Mark F Ciaccio et al.   NATURE METHODS

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells

(2010) M. Mazzone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variable slope normalization of reverse phase protein arrays

(2009) E. Shannon Neeley et al.   BIOINFORMATICS

Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics

(2009) B. T. Hennessy et al.   CANCER RESEARCH

Integrative Analysis of Cyclin Protein Levels Identifies Cyclin B1 as a Classifier and Predictor of Outcomes in Breast Cancer

(2009) R. Agarwal et al.   CLINICAL CANCER RESEARCH

Androgen Receptor Levels and Association with PIK3CA Mutations and Prognosis in Breast Cancer

(2009) A. M. Gonzalez-Angulo et al.   CLINICAL CANCER RESEARCH

Antibody-based proteomics

(2009) Hans Voshol et al.   FEBS Journal

Proteomic Biomarkers for Blast Neurotrauma: Targeting Cerebral Edema, Inflammation, and Neuronal Death Cascades

(2009) Denes V. Agoston et al.   JOURNAL OF NEUROTRAUMA

Multilayers of hydrogels loaded with microparticles: a fast and simple approach for microarray manufacturing

(2009) Marta Bally et al.   LAB ON A CHIP

The UCSC Cancer Genomics Browser

(2009) Jingchun Zhu et al.   NATURE METHODS

Core-Shell Hydrogel Particles Harvest, Concentrate and Preserve Labile Low Abundance Biomarkers

(2009) Caterina Longo et al.   PLoS One

Screening for C3 Deficiency in Newborns Using Microarrays

(2009) Magdalena Janzi et al.   PLoS One

IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas

(2009) L. M. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved reproducibility of reverse-phase protein microarrays using array microenvironment normalization

(2009) Troy Anderson et al.   PROTEOMICS

Tissue is alive: New technologies are needed to address the problems of protein biomarker pre-analytical variability

(2009) Virginia Espina et al.   Proteomics Clinical Applications

Experimental validation for quantitative protein network models

(2008) Satoshi Nishizuka et al.   CURRENT OPINION IN BIOTECHNOLOGY

Multiplexed Cell Signaling Analysis of Human Breast Cancer Applications for Personalized Therapy

(2008) Julia D. Wulfkuhle et al.   JOURNAL OF PROTEOME RESEARCH

Laser Capture Microdissection and Protein Microarray Analysis of Human Non-small Cell Lung Cancer

(2008) Amy J. VanMeter et al.   MOLECULAR & CELLULAR PROTEOMICS

A Portrait of Tissue Phosphoprotein Stability in the Clinical Tissue Procurement Process

(2008) Virginia Espina et al.   MOLECULAR & CELLULAR PROTEOMICS

Reverse-phase protein lysate microarrays for cell signaling analysis

(2008) Brett Spurrier et al.   Nature Protocols

Validation of reverse phase protein array for practical screening of potential biomarkers in serum and plasma: Accurate detection of CA19-9 levels in pancreatic cancer

(2008) Tobias Grote et al.   PROTEOMICS

Tracing pathway activities with kinase inhibitors and reverse phase protein arrays

(2008) Jan van Oostrum et al.   Proteomics Clinical Applications