Ceramide Induces the Death of Retina Photoreceptors Through Activation of Parthanatos

The dual role of poly(ADP-ribose) polymerase-1 in modulating parthanatos and autophagy under oxidative stress in rat cochlear marginal cells of the stria vascularis

(2018) Hong-Yan Jiang et al.   Redox Biology

Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists

(2017) G. Morris et al.   MOLECULAR NEUROBIOLOGY

Autophagy inhibits C2-ceramide-mediated cell death by decreasing the reactive oxygen species levels in SH-SY5Y cells

(2017) Chenghe Fan et al.   NEUROSCIENCE LETTERS

Temporal progression of PARP activity in the Prph2 mutant rd2 mouse: Neuroprotective effects of the PARP inhibitor PJ34

(2017) Ayse Sahaboglu et al.   PLoS One

Poly(ADP-ribose)polymerase-1 hyperactivation in neurodegenerative diseases: The death knell tolls for neurons

(2017) Parimala Narne et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis

(2017) Liane Jennifer Bailey et al.   Cell Death & Disease

Sphingolipid profile alters in retinal dystrophic P23H-1 rats and systemic FTY720 can delay retinal degeneration

(2016) Megan Stiles et al.   JOURNAL OF LIPID RESEARCH

Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response

(2016) Ruijuan Xu et al.   Oncotarget

Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration

(2016) Ayse Sahaboglu et al.   Scientific Reports

Very long chain ceramides interfere with C16-ceramide-induced channel formation: A plausible mechanism for regulating the initiation of intrinsic apoptosis

(2015) Johnny Stiban et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death

(2015) María José Hernández-Corbacho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dopaminergic Neurons Respond to Iron-Induced Oxidative Stress by Modulating Lipid Acylation and Deacylation Cycles

(2015) Sofía Sánchez Campos et al.   PLoS One

Poly(ADP-ribose): A signaling molecule in different paradigms of cell death

(2014) Francesca Aredia et al.   BIOCHEMICAL PHARMACOLOGY

PARP1-mediated necrosis is dependent on parallel JNK and Ca2+/calpain pathways

(2014) D. L. Douglas et al.   JOURNAL OF CELL SCIENCE

Ceramide in the Molecular Mechanisms of Neuronal Cell Death. The Role of Sphingosine-1-Phosphate

(2014) Kinga Czubowicz et al.   MOLECULAR NEUROBIOLOGY

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

(2014) S. A. Andrabi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cone survival and preservation of visual acuity in an animal model of retinal degeneration

(2013) Ilaria Piano et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration

(2013) Hui Chen et al.   JOURNAL OF LIPID RESEARCH

2′-Hydroxy C16-Ceramide Induces Apoptosis-Associated Proteomic Changes in C6 Glioma Cells

(2013) Venkatesh Kota et al.   JOURNAL OF PROTEOME RESEARCH

Induction of mitochondrial dysfunction by poly(ADP-ribose) polymer: Implication for neuronal cell death

(2013) Seung-Hoon Baek et al.   MOLECULES AND CELLS

TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation

(2012) S Jouan-Lanhouet et al.   CELL DEATH AND DIFFERENTIATION

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

(2012) Sahar A. Saddoughi et al.   EMBO Molecular Medicine

Sphingolipids: regulators of crosstalk between apoptosis and autophagy

(2012) Megan M. Young et al.   JOURNAL OF LIPID RESEARCH

C6-Ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth

(2011) Margaret Flowers et al.   BREAST CANCER RESEARCH AND TREATMENT

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos)

(2011) Y. Wang et al.   Science Signaling

Mitochondrial and Nuclear Cross Talk in Cell Death

(2010) Shaida A. Andrabi et al.   Annals of the New York Academy of Sciences

Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane

(2010) Vidyaramanan Ganesan et al.   APOPTOSIS

Ceramide channels and their role in mitochondria-mediated apoptosis

(2010) Marco Colombini   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Kdo2-Lipid A, a TLR4-specific Agonist, Inducesde NovoSphingolipid Biosynthesis in RAW264.7 Macrophages, Which Is Essential for Induction of Autophagy

(2010) Kacee Sims et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulating survival and development in the retina: key roles for simple sphingolipids

(2010) Nora P. Rotstein et al.   JOURNAL OF LIPID RESEARCH

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of ceramide biosynthesis preserves photoreceptor structure and function in a mouse model of retinitis pigmentosa

(2010) E. Strettoi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos

(2009) Yingfei Wang et al.   EXPERIMENTAL NEUROLOGY

Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos)

(2009) Yingfei Wang et al.   JOURNAL OF NEUROCHEMISTRY

Ceramide production associated with retinal apoptosis after retinal detachment

(2008) Marie-Laure Ranty et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY