Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration

α-Phenyl-N-tert-butylnitrone (PBN) Prevents Light-induced Degeneration of the Retina by Inhibiting RPE65 Protein Isomerohydrolase Activity

(2011) Md Nawajes A. Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of small-molecule inhibitors of sphingosine-1-phosphate signaling

(2011) Yvette Edmonds et al.   PHARMACOLOGY & THERAPEUTICS

Spingolipids in Multiple Sclerosis

(2010) Silke Walter et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Targeting Sphingosine 1-phosphate (S1P) Levels and S1P Receptor Functions for Therapeutic Immune Interventions

(2010) Markus H. Gräler   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Fingolimod is a potential novel therapy for multiple sclerosis

(2010) Orhan Aktas et al.   Nature Reviews Neurology

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biological Roles of Acid and Neutral Sphingomyelinases and Their Regulation by Nitric Oxide

(2010) Cristiana Perrotta et al.   PHYSIOLOGY

Inhibition of ceramide biosynthesis preserves photoreceptor structure and function in a mouse model of retinitis pigmentosa

(2010) E. Strettoi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system

(2009) Volker Brinkmann   BRITISH JOURNAL OF PHARMACOLOGY

Sphingolipids in inflammation: pathological implications and potential therapeutic targets

(2009) Graeme F. Nixon   BRITISH JOURNAL OF PHARMACOLOGY

Ceramide Synthesis Is Modulated by the Sphingosine Analog FTY720 via a Mixture of Uncompetitive and Noncompetitive Inhibition in an Acyl-CoA Chain Length-de pend ent Manner

(2009) Sujoy Lahiri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FTY720 Inhibits Ceramide Synthases and Up-regulates Dihydrosphingosine 1-Phosphate Formation in Human Lung Endothelial Cells

(2009) Evgeny V. Berdyshev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retinal light damage: Mechanisms and protection

(2009) Daniel T. Organisciak et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration

(2009) DanHong Zhu et al.   VISION RESEARCH

Fingolimod (FTY720) as an Acute Rescue Therapy for Intraocular Inflammatory Disease

(2008) B. J. E. Raveney et al.   ARCHIVES OF OPHTHALMOLOGY

Regulation of ceramide-induced neuronal death: Cell metabolism meets neurodegeneration

(2008) Gonzalo Arboleda et al.   BRAIN RESEARCH REVIEWS

Topography of retinal damage in light-exposed albino rats

(2008) Masaki Tanito et al.   EXPERIMENTAL EYE RESEARCH

Curcumin protects retinal cells from light-and oxidant stress-induced cell death

(2008) Md Nawajes A. Mandal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ceramide production associated with retinal apoptosis after retinal detachment

(2008) Marie-Laure Ranty et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration

(2008) Masaki Tanito et al.   JOURNAL OF LIPID RESEARCH

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY