Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy
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Title
Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy
Authors
Keywords
Mesenchymal stromal cells (MSCs), Hepatocellular carcinoma (HCC), Chemotaxis, Carcinogenesis, Neoplasm metastasis, Tumor-targeted therapy
Journal
Molecular Cancer
Volume 17, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-12-28
DOI
10.1186/s12943-018-0926-6
References
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Note: Only part of the references are listed.- Targeting the microenvironment in solid tumors
- (2018) Carmen Belli et al. CANCER TREATMENT REVIEWS
- Hepatoma cell-secreted exosomal microRNA-103 increases vascular permeability and promotes metastasis by targeting junction proteins
- (2018) Jian-Hong Fang et al. HEPATOLOGY
- IL-6/STAT3 pathway intermediates M1/M2 macrophage polarization during the development of hepatocellular carcinoma
- (2018) Zi Yin et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Extracellular vesicle therapeutics for liver disease
- (2018) David A. Borrelli et al. JOURNAL OF CONTROLLED RELEASE
- Exosomes released by hepatocarcinoma cells endow adipocytes with tumor-promoting properties
- (2018) Shihua Wang et al. Journal of Hematology & Oncology
- Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial
- (2018) Masatoshi Kudo et al. LANCET
- Apoptosis and non-alcoholic fatty liver diseases
- (2018) Tatsuo Kanda et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer
- (2018) Tian Fang et al. Nature Communications
- CCL15 recruits suppressive monocytes to facilitate immune escape and disease progression in hepatocellular carcinoma
- (2018) Long-Zi Liu et al. HEPATOLOGY
- Emerging roles of Myc in stem cell biology and novel tumor therapies
- (2018) Go J. Yoshida JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- The role of sema4D in vasculogenic mimicry formation in non-small cell lung cancer and the underlying mechanisms
- (2018) Yun Xia et al. INTERNATIONAL JOURNAL OF CANCER
- Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial
- (2017) Jordi Bruix et al. LANCET
- Oncogenic Signal and Tumor Microenvironment in Hepatocellular Carcinoma
- (2017) Naoshi Nishida et al. ONCOLOGY
- In vivo hepatic differentiation potential of human umbilical cord-derived mesenchymal stem cells: Therapeutic effect on liver fibrosis/cirrhosis
- (2017) Guo-Zun Zhang et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
- (2017) David Kung-Chun Chiu et al. Nature Communications
- Human mesenchymal stem cells preferentially migrate toward highly oncogenic human hepatocellular carcinoma cells with activated EpCAM signaling
- (2017) Berwini Endaya et al. Oncotarget
- Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment
- (2016) Genichiro Ishii et al. ADVANCED DRUG DELIVERY REVIEWS
- Mesenchymal stem cells enhance the metastasis of 3D-cultured hepatocellular carcinoma cells
- (2016) Chang Liu et al. BMC CANCER
- Overexpression of hepatocyte nuclear factor 4α in human mesenchymal stem cells suppresses hepatocellular carcinoma development through Wnt/β-catenin signaling pathway downregulation
- (2016) Ning Wu et al. CANCER BIOLOGY & THERAPY
- Hedgehog Signaling Activation in Hepatic Stellate Cells Promotes Angiogenesis and Vascular Mimicry in Hepatocellular Carcinoma
- (2016) Wei Li et al. CANCER INVESTIGATION
- Vascular mimicry formation is promoted by paracrine TGF-β and SDF1 of cancer-associated fibroblasts and inhibited by miR-101 in hepatocellular carcinoma
- (2016) Jine Yang et al. CANCER LETTERS
- A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion
- (2016) Raffaela Fontanella et al. CANCER LETTERS
- Mesenchymal stem cells deliver and release conditionally replicative adenovirus depending on hepatic differentiation to eliminate hepatocellular carcinoma cells specifically
- (2016) Xiangfei Yuan et al. CANCER LETTERS
- Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways
- (2016) Jiao Liu et al. CANCER LETTERS
- Hepatic stellate cell promoted hepatoma cell invasion via the HGF/c-Met signaling pathway regulated by p53
- (2016) Wen-Ting Liu et al. CELL CYCLE
- IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment
- (2016) Xin Zheng et al. CELLULAR SIGNALLING
- Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26
- (2016) David Kung-Chun Chiu et al. HEPATOLOGY
- Hepatic stellate cells induce hepatocellular carcinoma cell resistance to sorafenib through the laminin-332/α3 integrin axis recovery of focal adhesion kinase ubiquitination
- (2016) Amalia Azzariti et al. HEPATOLOGY
- Cannabinoid Receptor 1 Mediates Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury
- (2016) Lin Wang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Nestin overexpression in hepatocellular carcinoma associates with epithelial-mesenchymal transition and chemoresistance
- (2016) Yan Zhang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Emerging role of epithelial-mesenchymal transition in hepatic cancer
- (2016) Go J. Yoshida JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Inhibitory effect of genetically engineered mesenchymal stem cells with Apoptin on hepatoma cells in vitro and in vivo
- (2016) Jingsi Zhang et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Chemokine CCL15 Mediates Migration of Human Bone Marrow-Derived Mesenchymal Stem Cells Toward Hepatocellular Carcinoma
- (2016) Yun Gao et al. STEM CELLS
- Cancer-associated fibroblasts in hepatocellular carcinoma
- (2016) Norio Kubo et al. WORLD JOURNAL OF GASTROENTEROLOGY
- GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer
- (2016) M. Waghray et al. Cancer Discovery
- IL-8, GRO and MCP-1 produced by hepatocellular carcinoma microenvironment determine the migratory capacity of human bone marrow-derived mesenchymal stromal cells without affecting tumor aggressiveness
- (2016) Juan Bayo et al. Oncotarget
- Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation
- (2016) J-t Cheng et al. Oncogenesis
- Global cancer statistics, 2012
- (2015) Lindsey A. Torre et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Hepatic stellate cells activated by acidic tumor microenvironment promote the metastasis of hepatocellular carcinoma via osteopontin
- (2015) Jin Song et al. CANCER LETTERS
- Therapeutic strategies targeting cancer stem cells
- (2015) Go J. Yoshida et al. CANCER SCIENCE
- Thyroid hormones and tetrac: new regulators of tumour stroma formation via integrin αvβ3
- (2015) Kathrin A Schmohl et al. ENDOCRINE-RELATED CANCER
- Protective effects of hepatic stellate cells against cisplatin-induced apoptosis in human hepatoma G2 cells
- (2015) LEI ZHANG et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma
- (2015) Guohua Lou et al. Journal of Hematology & Oncology
- Activated hepatic stellate cells promote angiogenesis via interleukin-8 in hepatocellular carcinoma
- (2015) Bing Zhu et al. Journal of Translational Medicine
- Interferon-α2b gene-modified human bone marrow mesenchymal stem cells inhibit hepatocellular carcinoma by reducing the Notch1 levels
- (2015) Yanjun Su et al. LIFE SCIENCES
- Paracrine Factors of Human Fetal MSCs Inhibit Liver Cancer Growth Through Reduced Activation of IGF-1R/PI3K/Akt Signaling
- (2015) Yulyana Yulyana et al. MOLECULAR THERAPY
- CCL20-CCR6 Cytokine Network Facilitate TregActivity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma
- (2015) W.-M. Li et al. SCANDINAVIAN JOURNAL OF IMMUNOLOGY
- Mesenchymal Stem Cells Isolated From Human Gliomas Increase Proliferation and Maintain Stemness of Glioma Stem Cells Through the IL-6/gp130/STAT3 Pathway
- (2015) Anwar Hossain et al. STEM CELLS
- Inflammatory Chemokines MIP-1δ and MIP-3α Are Involved in the Migration of Multipotent Mesenchymal Stromal Cells Induced by Hepatoma Cells
- (2015) Esma Lejmi et al. STEM CELLS AND DEVELOPMENT
- Contribution and Mobilization of Mesenchymal Stem Cells in a mouse model of carbon tetrachloride-induced liver fibrosis
- (2015) Yan Liu et al. Scientific Reports
- Quantification of Mesenchymal Stem Cells (MSCs) at Sites of Human Prostate Cancer
- (2015) W. Nathaniel Brennen et al. Oncotarget
- Suppression of orthotopically implanted hepatocarcinoma in mice by umbilical cord-derived mesenchymal stem cells with sTRAIL gene expression driven by AFP promoter
- (2014) Cihui Yan et al. BIOMATERIALS
- Deregulated microRNAs in gastric cancer tissue-derived mesenchymal stem cells: novel biomarkers and a mechanism for gastric cancer
- (2014) M Wang et al. BRITISH JOURNAL OF CANCER
- B7-H3 was Highly Expressed in Human Primary Hepatocellular Carcinoma and Promoted Tumor Progression
- (2014) Feifei Wang et al. CANCER INVESTIGATION
- Mesenchymal Stem Cells Are Recruited into Wounded Skin and Contribute to Wound Repair by Transdifferentiation into Multiple Skin Cell Type
- (2014) M. Sasaki et al. JOURNAL OF IMMUNOLOGY
- Increased Migration of Human Mesenchymal Stromal Cells by Autocrine Motility Factor (AMF) Resulted in Enhanced Recruitment towards Hepatocellular Carcinoma
- (2014) Juan Bayo et al. PLoS One
- Hepatoma SK Hep-1 Cells Exhibit Characteristics of Oncogenic Mesenchymal Stem Cells with Highly Metastatic Capacity
- (2014) Jong Ryeol Eun et al. PLoS One
- MYC Is an Early Response Regulator of Human Adipogenesis in Adipose Stem Cells
- (2014) Chad Deisenroth et al. PLoS One
- Human Umbilical Cord Perivascular Cells Exhibited Enhanced Migration Capacity towards Hepatocellular Carcinoma in Comparison with Bone Marrow Mesenchymal Stromal Cells: A Role for Autocrine Motility Factor Receptor
- (2014) Juan Bayo et al. Biomed Research International
- Interferon-β gene-modified human bone marrow mesenchymal stem cells attenuate hepatocellular carcinoma through inhibiting AKT/FOXO3a pathway
- (2013) C Xie et al. BRITISH JOURNAL OF CANCER
- Tumor promotion through the mesenchymal stem cell compartment in human hepatocellular carcinoma
- (2013) Pratika Y. Hernanda et al. CARCINOGENESIS
- Colon cancer mesenchymal stem cells modulate the tumorigenicity of colon cancer through interleukin 6
- (2013) Jen-Tsun Lin et al. EXPERIMENTAL CELL RESEARCH
- Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma
- (2013) Virginia Hernandez–Gea et al. GASTROENTEROLOGY
- Hepatocellular carcinoma-associated mesenchymal stem cells promote hepatocarcinoma progression: Role of the S100A4-miR155-SOCS1-MMP9 axis
- (2013) Xin-Long Yan et al. HEPATOLOGY
- Stromal Targeting of Sodium Iodide Symporter Using Mesenchymal Stem Cells Allows Enhanced Imaging and Therapy of Hepatocellular Carcinoma
- (2013) Kerstin Knoop et al. HUMAN GENE THERAPY
- Systemically delivered measles virus-infected mesenchymal stem cells can evade host immunity to inhibit liver cancer growth
- (2013) Hooi-Tin Ong et al. JOURNAL OF HEPATOLOGY
- CXCL12/CXCR4 axis promotes mesenchymal stem cell mobilization to burn wounds and contributes to wound repair
- (2013) Changjiang Hu et al. JOURNAL OF SURGICAL RESEARCH
- Hepatic stellate cells promote tumor progression by enhancement of immunosuppressive cells in an orthotopic liver tumor mouse model
- (2013) Wenxiu Zhao et al. LABORATORY INVESTIGATION
- T-cell apoptosis induced by intratumoral activated hepatic stellate cells is associated with lung metastasis in hepatocellular carcinoma
- (2013) YUN-HONG XIA et al. ONCOLOGY REPORTS
- Tumor and its microenvironment: A synergistic interplay
- (2013) Veronica Catalano et al. SEMINARS IN CANCER BIOLOGY
- Effect of bone marrow mesenchymal stem cells on hepatocellular carcinoma in microcirculation
- (2013) Peng Gong et al. TUMOR BIOLOGY
- Effect of Mesenchymal Stem Cells and a Novel Curcumin Derivative on Notch1 Signaling in Hepatoma Cell Line
- (2013) Mohamed Talaat Abdel Aziz et al. Biomed Research International
- The inhibitory effect of MSCs expressing TRAIL as a cellular delivery vehicle in combination with cisplatin on hepatocellular carcinoma
- (2012) Bo Zhang et al. CANCER BIOLOGY & THERAPY
- Efficacy of Mesenchymal Stem Cells Derived from Human Adipose Tissue in Inhibition of Hepatocellular Carcinoma Cells In Vitro
- (2012) Wenxiu Zhao et al. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
- Mesenchymal stromal cells derived from umbilical cord blood migrate in response to complement C1q
- (2012) Yuanyuan Qiu et al. CYTOTHERAPY
- Mesenchymal stem cells seldomly fuse with hepatocellular carcinoma cells and are mainly distributed in the tumor stroma in mouse models
- (2012) GUO-CAI LI et al. ONCOLOGY REPORTS
- Nuclear Translocation of β-Catenin during Mesenchymal Stem Cells Differentiation into Hepatocytes Is Associated with a Tumoral Phenotype
- (2012) Carmen Herencia et al. PLoS One
- IL1β Induces Mesenchymal Stem Cells Migration and Leucocyte Chemotaxis Through NF-κB
- (2012) Rubén Carrero et al. Stem Cell Reviews and Reports
- Injury-Activated Transforming Growth Factor β Controls Mobilization of Mesenchymal Stem Cells for Tissue Remodeling
- (2012) Mei Wan et al. STEM CELLS
- Microvesicles Derived from Human Bone Marrow Mesenchymal Stem Cells Inhibit Tumor Growth
- (2012) Stefania Bruno et al. STEM CELLS AND DEVELOPMENT
- Human mesenchymal stem cell and epithelial hepatic carcinoma cell lines in admixture: Concurrent stimulation of cancer-associated fibroblasts and epithelial-to-mesenchymal transition markers
- (2012) Syamal D. Bhattacharya et al. SURGERY
- The Inflammatory Microenvironment in Hepatocellular Carcinoma: A Pivotal Role for Tumor-Associated Macrophages
- (2012) Daria Capece et al. Biomed Research International
- Selective Targeting of Genetically Engineered Mesenchymal Stem Cells to Tumor Stroma Microenvironments Using Tissue-Specific Suicide Gene Expression Suppresses Growth of Hepatocellular Carcinoma
- (2011) Hanno Niess et al. ANNALS OF SURGERY
- Mesenchymal stem cells from primary breast cancer tissue promote cancer proliferation and enhance mammosphere formation partially via EGF/EGFR/Akt pathway
- (2011) Xin-long Yan et al. BREAST CANCER RESEARCH AND TREATMENT
- Hepatic stellate cells stimulate HCC cell migration via laminin-5 production
- (2011) Angela Santamato et al. CLINICAL SCIENCE
- Stromal cell-derived factor-1 (SDF-1): homing factor for engineered regenerative medicine
- (2011) Ting Ting Lau et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Management of hepatocellular carcinoma: An update
- (2011) Jordi Bruix et al. HEPATOLOGY
- Human ovarian carcinoma–associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production
- (2011) Karen McLean et al. JOURNAL OF CLINICAL INVESTIGATION
- Hepatocellular Carcinoma Cells and Their Fibrotic Microenvironment Modulate Bone Marrow-Derived Mesenchymal Stromal Cell Migrationin Vitroandin Vivo
- (2011) Mariana G. Garcia et al. MOLECULAR PHARMACEUTICS
- Image-guided, Tumor Stroma-targeted 131I Therapy of Hepatocellular Cancer After Systemic Mesenchymal Stem Cell-mediated NIS Gene Delivery
- (2011) Kerstin Knoop et al. MOLECULAR THERAPY
- Hepatocellular Carcinoma
- (2011) Hashem B. El-Serag NEW ENGLAND JOURNAL OF MEDICINE
- Bone Marrow-Derived Mesenchymal Stromal Cells are Attracted by Multiple Myeloma Cell-Produced Chemokine CCL25 and Favor Myeloma Cell Growth in Vitro and In Vivo
- (2011) Song Xu et al. STEM CELLS
- Human mesenchymal stem cells inhibit metastasis of a hepatocellular carcinoma model using the MHCC97-H cell line
- (2010) Guo-Cai Li et al. CANCER SCIENCE
- Interleukin 6 mediated recruitment of mesenchymal stem cells to the hypoxic tumor milieu
- (2010) Yanique Rattigan et al. EXPERIMENTAL CELL RESEARCH
- Isolation and comparison of mesenchymal stem-like cells from human gastric cancer and adjacent non-cancerous tissues
- (2010) Xiaomeng Xu et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Human mesenchymal stem cells overexpressing pigment epithelium-derived factor inhibit hepatocellular carcinoma in nude mice
- (2010) Y Gao et al. ONCOGENE
- The tumor microenvironment in hepatocellular carcinoma: Current status and therapeutic targets
- (2010) Ju Dong Yang et al. SEMINARS IN CANCER BIOLOGY
- Chemokine Profile of Human Serum from Whole Blood: Migratory Effects of CXCL-10 and CXCL-11 on Human Mesenchymal Stem Cells
- (2009) Gregor Kalwitz et al. CONNECTIVE TISSUE RESEARCH
- Recruitment of endogenous bone marrow mesenchymal stem cells towards injured liver
- (2009) Ye Chen et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis
- (2009) Changyong Li et al. JOURNAL OF HEPATOLOGY
- C3a and C5a Are Chemotactic Factors for Human Mesenchymal Stem Cells, Which Cause Prolonged ERK1/2 Phosphorylation
- (2009) I. U. Schraufstatter et al. JOURNAL OF IMMUNOLOGY
- TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation
- (2009) Yi Tang et al. NATURE MEDICINE
- Direct Evidence of Mesenchymal Stem Cell Tropism for Tumor and Wounding Microenvironments Using In Vivo Bioluminescent Imaging
- (2009) Shannon Kidd et al. STEM CELLS
- Migration of bone marrow-derived mesenchymal stem cells induced by tumor necrosis factor-α and its possible role in wound healing
- (2009) Xiaobing Fu et al. WOUND REPAIR AND REGENERATION
- NF-κB downregulation may be involved the depression of tumor cell proliferation mediated by human mesenchymal stem cells
- (2008) Ling QIAO et al. ACTA PHARMACOLOGICA SINICA
- Mesenchymal stem cell-like cells derived from human gastric cancer tissues
- (2008) Huiling Cao et al. CANCER LETTERS
- Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model
- (2008) Ling Qiao et al. CELL RESEARCH
- A Tumor-selective Biotherapy With Prolonged Impact on Established Metastases Based on Cytokine Gene-engineered MSCs
- (2008) Xiancheng Chen et al. MOLECULAR THERAPY
- Cancer-related inflammation
- (2008) Alberto Mantovani et al. NATURE
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