DDX3 functions in antiviral innate immunity through translational control of PACT

Middle East Respiratory Syndrome Coronavirus 4a Protein Is a Double-Stranded RNA-Binding Protein That Suppresses PACT-Induced Activation of RIG-I and MDA5 in the Innate Antiviral Response

(2014) K.-L. Siu et al.   JOURNAL OF VIROLOGY

The DEAD-box helicase Ded1 from yeast is an mRNP cap-associated protein that shuttles between the cytoplasm and nucleus

(2014) Meriem Senissar et al.   NUCLEIC ACIDS RESEARCH

DDX3 modulates cell adhesion and motility and cancer cell metastasis via Rac1-mediated signaling pathway

(2014) H-H Chen et al.   ONCOGENE

DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication

(2013) Anthony Fullam et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mutual Antagonism between the Ebola Virus VP35 Protein and the RIG-I Activator PACT Determines Infection Outcome

(2013) Priya Luthra et al.   Cell Host & Microbe

Suppression of PACT-Induced Type I Interferon Production by Herpes Simplex Virus 1 Us11 Protein

(2013) C. Kew et al.   JOURNAL OF VIROLOGY

Human DEAD Box Helicase 3 Couples I B Kinase   to Interferon Regulatory Factor 3 Activation

(2013) L. Gu et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of hepatic innate immunity by hepatitis C virus

(2013) Stacy M Horner et al.   NATURE MEDICINE

The DEAD-box helicase DDX3 substitutes for the cap-binding protein eIF4E to promote compartmentalized translation initiation of the HIV-1 genomic RNA

(2013) Ricardo Soto-Rifo et al.   NUCLEIC ACIDS RESEARCH

Human DDX3 Interacts with the HIV-1 Tat Protein to Facilitate Viral mRNA Translation

(2013) Ming-Chih Lai et al.   PLoS One

Antiviral RNA Interference in Mammalian Cells

(2013) P. V. Maillard et al.   SCIENCE

DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs

(2012) Ricardo Soto-Rifo et al.   EMBO JOURNAL

Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response

(2011) Jing-Wen Shih et al.   BIOCHEMICAL JOURNAL

The Double-Stranded RNA-Binding Protein PACT Functions as a Cellular Activator of RIG-I to Facilitate Innate Antiviral Response

(2011) Kin-Hang Kok et al.   Cell Host & Microbe

Identification of hnRNPH1, NF45, and C14orf166 as Novel Host Interacting Partners of the Mature Hepatitis C Virus Core Protein

(2011) Jun-Wei Lee et al.   JOURNAL OF PROTEOME RESEARCH

The DEAD-Box Protein Ded1 Modulates Translation by the Formation and Resolution of an eIF4F-mRNA Complex

(2011) Angela Hilliker et al.   MOLECULAR CELL

The Role of Dicer Protein Partners in the Processing of MicroRNA Precursors

(2011) Edyta Koscianska et al.   PLoS One

DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-β-inducing potential

(2010) Hiroyuki Oshiumi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Polo-Like Kinase 1 Is Involved in Hepatitis C Virus Replication by Hyperphosphorylating NS5A

(2010) Y.-C. Chen et al.   JOURNAL OF VIROLOGY

DDX3 Regulates Cell Growth through Translational Control of Cyclin E1

(2010) M.-C. Lai et al.   MOLECULAR AND CELLULAR BIOLOGY

Hepatitis C Virus Core Protein Abrogates the DDX3 Function That Enhances IPS-1-Mediated IFN–Beta Induction

(2010) Hiroyuki Oshiumi et al.   PLoS One

The current understanding of Ded1p/DDX3 homologs from yeast to human

(2010) Woan-Yuh Tarn et al.   RNA Biology

Hepatitis B Virus Polymerase Blocks Pattern Recognition Receptor Signaling via Interaction with DDX3: Implications for Immune Evasion

(2010) Haifeng Wang et al.   PLoS Pathogens

Toll-like Receptor and RIG-1-like Receptor Signaling

(2009) Taro Kawai et al.   Annals of the New York Academy of Sciences

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response

(2008) Didier Soulat et al.   EMBO JOURNAL

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKɛ-mediated IRF activation

(2008) Martina Schröder et al.   EMBO JOURNAL

The DEAD-Box RNA Helicase DDX3 Associates with Export Messenger Ribonucleoproteins as well asTip-associated Protein and Participates in Translational Control

(2008) Ming-Chih Lai et al.   MOLECULAR BIOLOGY OF THE CELL

Knockdown of Cellular RNA Helicase DDX3 by Short Hairpin RNAs Suppresses HIV-1 Viral Replication Without Inducing Apoptosis

(2008) Musarat Ishaq et al.   MOLECULAR BIOTECHNOLOGY

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

(2008) Takeshi Saito et al.   NATURE

Human DDX3 functions in translation and interacts with the translation initiation factor eIF3

(2008) C.-S. Lee et al.   NUCLEIC ACIDS RESEARCH

Oncogenic role of DDX3 in breast cancer biogenesis

(2008) M Botlagunta et al.   ONCOGENE