Placental Ras Regulates Inflammation Associated with Maternal Obesity

Placental Pim-1 expression is increased in obesity and regulates cytokine- and toll-like receptor-mediated inflammation

(2017) Stella Liong et al.   PLACENTA

Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria SyndromeClinical Perspective

(2016) Leslie B. Gordon et al.   CIRCULATION

Prognostic impact of KRAS, NRAS, BRAF, and PIK3CA mutations in primary colorectal carcinomas: a population-based study

(2016) Grazia Palomba et al.   Journal of Translational Medicine

Chronic inflammation initiates multiple forms of K-Ras-independent mouse pancreatic cancer in the absence of TP53

(2016) A K Swidnicka-Siergiejko et al.   ONCOGENE

Inflammation as a driver and vulnerability of KRAS mediated oncogenesis

(2016) Shunsuke Kitajima et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Obesity and Placental Function

(2016) Alina Maloyan et al.   SEMINARS IN REPRODUCTIVE MEDICINE

PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes

(2016) B Anta et al.   Cell Death & Disease

Oral prenylation inhibition with lonafarnib in chronic hepatitis D infection: a proof-of-concept randomised, double-blind, placebo-controlled phase 2A trial

(2015) Christopher Koh et al.   LANCET INFECTIOUS DISEASES

Increasing Maternal Body Mass Index Is Associated with Systemic Inflammation in the Mother and the Activation of Distinct Placental Inflammatory Pathways1

(2014) Irving L.M.H. Aye et al.   BIOLOGY OF REPRODUCTION

The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells

(2014) Tal Leibovich-Rivkin et al.   BMC CANCER

Chemical Biology Tools for Regulating RAS Signaling Complexity in Space and Time

(2014) Hilde van Hattum et al.   CHEMISTRY & BIOLOGY

The Effect of Maternal Obesity on the Offspring

(2014) CHRISTINE B. WILLIAMS et al.   CLINICAL OBSTETRICS AND GYNECOLOGY

The NR4A receptors Nurr1 and Nur77 are increased in human placenta from women with gestational diabetes

(2014) M. Lappas   PLACENTA

Maternal obesity is associated with a lipotoxic placental environment

(2014) J. Saben et al.   PLACENTA

Mutant KRAS–Induced Expression of ICAM-1 in Pancreatic Acinar Cells Causes Attraction of Macrophages to Expedite the Formation of Precancerous Lesions

(2014) Geou-Yarh Liou et al.   Cancer Discovery

Maternal Obesity, Inflammation, and Developmental Programming

(2014) Stephanie A. Segovia et al.   Biomed Research International

Early growth response protein-1 mediates lipotoxicity-associated placental inflammation: role in maternal obesity

(2013) Jessica Saben et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium

(2013) Ratana Lim et al.   MOLECULAR HUMAN REPRODUCTION

Drug for an 'undruggable' protein

(2013) Nicole M. Baker et al.   NATURE

Apelin Is Decreased With Human Preterm and Term Labor and Regulates Prolabor Mediators in Human Primary Amnion Cells

(2013) Ratana Lim et al.   Reproductive Sciences

TREM-1 Expression Is Increased in Human Placentas From Severe Early-Onset Preeclamptic Pregnancies Where It May Be Involved in Syncytialization

(2013) Ratana Lim et al.   Reproductive Sciences

Cigarette Smoking and Colorectal Cancer Risk by KRAS Mutation Status Among Older Women

(2012) N J Samadder et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The risk of maternal obesity to the long-term health of the offspring

(2012) James R. O'Reilly et al.   CLINICAL ENDOCRINOLOGY

New prognostic factors and calculators for outcome prediction in patients with recurrent glioblastoma: A pooled analysis of EORTC Brain Tumour Group phase I and II clinical trials

(2012) Thierry Gorlia et al.   EUROPEAN JOURNAL OF CANCER

Activation of Placental mTOR Signaling and Amino Acid Transporters in Obese Women Giving Birth to Large Babies

(2012) Nina Jansson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

An NF-κB pathway–mediated positive feedback loop amplifies Ras activity to pathological levels in mice

(2012) Jaroslaw Daniluk et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of NF-κB Is a Novel Target of KRAS-Induced Endometrial Carcinogenesis

(2011) Yasunari Mizumoto et al.   CLINICAL CANCER RESEARCH

The maternal womb

(2011) Frank A. Simmen et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Maternal Diabetes in Pregnancy: Early and Long-Term Outcomes on the Offspring and the Concept of “Metabolic Memory”

(2011) Akadiri Yessoufou et al.   Experimental Diabetes Research

Placental structure and inflammation in pregnancies associated with obesity

(2011) K.A. Roberts et al.   PLACENTA

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Future predictions of body mass index and overweight prevalence in Australia, 2005-2025

(2011) M. M. Haby et al.   HEALTH PROMOTION INTERNATIONAL

Clinical Relevance of KRAS in Human Cancers

(2010) Sylwia Jančík et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Pregravid Obesity Associates With Increased Maternal Endotoxemia and Metabolic Inflammation

(2010) Subhabrata Basu et al.   Obesity

Maternal Gestational Weight Gain and Offspring Weight in Adolescence

(2010) Emily Oken et al.   OBSTETRICS AND GYNECOLOGY

Maternal obesity and markers of inflammation in pregnancy

(2009) Juliette C. Madan et al.   CYTOKINE

Non-redundancy within the RAS oncogene family: Insights into mutational disparities in cancer

(2009) Ken S. Lau et al.   MOLECULES AND CELLS

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

Weight Status in the First 6 Months of Life and Obesity at 3 Years of Age

(2009) E. M. Taveras et al.   PEDIATRICS

Altered Energy Homeostasis and Resistance to Diet-Induced Obesity in KRAP-Deficient Mice

(2009) Takahiro Fujimoto et al.   PLoS One

Maternal obesity, length of gestation, risk of postdates pregnancy and spontaneous onset of labour at term

(2008) FC Denison et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Obesity in Pregnancy Stimulates Macrophage Accumulation and Inflammation in the Placenta

(2008) J.C. Challier et al.   PLACENTA