Gene Silencing With Small Interfering RNA: A New Therapeutic Option During Ex Vivo Machine Liver Perfusion Preservation

Hypothermic oxygenated machine perfusion reduces bile duct reperfusion injury after transplantation of donation after circulatory death livers

(2018) Rianne van Rijn et al.   LIVER TRANSPLANTATION

Hypothermic machine perfusion in liver transplantation

(2018) R. Cutler Quillin et al.   LIVER TRANSPLANTATION

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

(2018) Matthew R Hassler et al.   NUCLEIC ACIDS RESEARCH

A randomized trial of normothermic preservation in liver transplantation

(2018) David Nasralla et al.   NATURE

Silencing p53 Pathway of Apoptosis Alleviates Ischemia-Reperfusion Injury (IRI) in the Liver

(2017) Maximiliaan F. Thijssen et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Liver ex situ machine perfusion preservation: A review of the methodology and results of large animal studies and clinical trials

(2017) Hazel Marecki et al.   LIVER TRANSPLANTATION

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

Oligonucleotide Therapeutics — A New Class of Cholesterol-Lowering Drugs

(2017) Anastasia Khvorova   NEW ENGLAND JOURNAL OF MEDICINE

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9

(2017) Kevin Fitzgerald et al.   NEW ENGLAND JOURNAL OF MEDICINE

Liver Transplantation AfterEx VivoNormothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial

(2016) R. Ravikumar et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Liver Bid suppression for treatment of fibrosis associated with non-alcoholic steatohepatitis

(2016) Akiko Eguchi et al.   JOURNAL OF HEPATOLOGY

Small interfering RNA targeting TNF-α gene significantly attenuates renal ischemia-reperfusion injury in mice

(2016) Ling Hou et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Normothermic ex vivo liver perfusion using steen solution as perfusate for human liver transplantation: First North American results

(2016) Markus Selzner et al.   LIVER TRANSPLANTATION

Attenuating Ischemia-Reperfusion Injury in Kidney Transplantation by Perfusing Donor Organs With siRNA Cocktail Solution

(2016) Xiufen Zheng et al.   TRANSPLANTATION

IRAK-4-shRNA Prevents Ischemia/Reperfusion Injury Via Different Perfusion Periods Through the Portal Vein After Liver Transplantation in Rat

(2016) Y. Wu et al.   TRANSPLANTATION PROCEEDINGS

Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies

(2014) Yan Deng et al.   GENE

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu

(2013) Carmen Peralta et al.   JOURNAL OF HEPATOLOGY

Small Interfering RNA Targeting Nuclear Factor Kappa B to Prevent Vein Graft Stenosis in Rat Models

(2013) X.B. Meng et al.   TRANSPLANTATION PROCEEDINGS

RNA-Based Therapeutics: Current Progress and Future Prospects

(2012) John C. Burnett et al.   CHEMISTRY & BIOLOGY

RNA interference targeting RelB attenuates liver ischemia/reperfusion injury

(2012) Lei Luo et al.   JOURNAL OF SURGICAL RESEARCH

Naked caspase 3 small interfering RNA is effective in cold preservation but not in autotransplantation of porcine kidneys

(2012) Cheng Yang et al.   JOURNAL OF SURGICAL RESEARCH

Targeted Gene Silencing of TLR4 Using Liposomal Nanoparticles for Preventing Liver Ischemia Reperfusion Injury

(2011) N. Jiang et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Reduction of Liver Ischemia Reperfusion Injury by Silencing of TNF-α Gene with shRNA

(2011) Roberto Hernandez-Alejandro et al.   JOURNAL OF SURGICAL RESEARCH

Delivery of siRNA Therapeutics: Barriers and Carriers

(2010) Jie Wang et al.   AAPS Journal

Intravital Two-Photon Microscopy Assessment of Renal Protection Efficacy of siRNA for p53 in Experimental Rat Kidney Transplantation Models

(2010) Ryoichi Imamura et al.   CELL TRANSPLANTATION

Gene Silencing of NALP3 Protects Against Liver Ischemia–Reperfusion Injury in Mice

(2010) Ping Zhu et al.   HUMAN GENE THERAPY

Liver ischemia/reperfusion injury: Processes in inflammatory networks-A review

(2010) Mahmoud Abu-Amara et al.   LIVER TRANSPLANTATION

The RNA-induced Silencing Complex: A Versatile Gene-silencing Machine

(2009) Ashley J. Pratt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

siRNA Targeted to p53 Attenuates Ischemic and Cisplatin-Induced Acute Kidney Injury

(2009) B. A. Molitoris et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Small Interfering RNA Targeting RelB Protects Against Renal Ischemia-reperfusion Injury

(2009) Biao Feng et al.   TRANSPLANTATION

Gene Silencing of Complement C5a Receptor Using siRNA for Preventing Ischemia/Reperfusion Injury

(2008) Xiufen Zheng et al.   AMERICAN JOURNAL OF PATHOLOGY

RNAi mechanisms and applications

(2008) Daniel H. Kim et al.   BIOTECHNIQUES