Review
Pharmacology & Pharmacy
Lais Ribovski, Naomi M. Hamelmann, Jos M. J. Paulusse
Summary: Safe and reliable entry into the brain is crucial for successful treatment of central nervous system disorders, but remains challenging. Nano-sized systems as drug carriers show significant improvements in therapy delivery. Careful design of NP properties is essential for successful brain delivery, affecting the ability to overcome multiple barriers.
Article
Clinical Neurology
Abbie C. Johnson
Summary: With the increase in aging population and lack of effective treatments for dementia, the incidence of age-related dementia is on the rise. Vascular factors contributing to cognitive impairment and dementia are also increasing due to the prevalence of cerebrovascular diseases such as chronic hypertension, diabetes, and ischemic stroke. This review focuses on the role of the hippocampal vasculature in maintaining neurocognitive health, its contribution to vascular cognitive impairment and dementia, and its potential as a therapeutic target to slow cognitive decline.
Review
Pharmacology & Pharmacy
Prabhjot Kaur, Ankita Rajput, Dilpreet Singh, Gurdeep Singh, Anshula Mehra, Sarabjit Kaur, Neena Bedi, Saroj Arora
Summary: The brain is a delicate organ with multiple defense mechanisms, such as the blood-brain barrier and multidrug resistance transporters, that make it difficult to target neurological diseases. Polymeric micelles have emerged as a promising therapeutic approach for brain delivery due to their ability to improve drug solubility and target specific cells. This review focuses on the preparation method, formulation mechanism, and clinical trials of polymeric micelles for brain delivery.
CURRENT DRUG DELIVERY
(2023)
Review
Chemistry, Multidisciplinary
Fatemeh Madani, Seyedeh Sara Esnaashari, Thomas J. Webster, Masood Khosravani, Mahdi Adabi
Summary: This review discusses the challenges of delivering drugs through the blood-brain barrier (BBB) in glioblastoma (GBM) treatment and introduces the latest advances in using nanoparticles for this purpose. It also describes the development of drug delivery and combination modalities using natural and synthetic polymer nanoparticles, as well as adjuvant therapies for GBM treatment. Additionally, it explains the receptor-mediated endocytosis agents that exist in brain endothelial capillary cells and emphasizes future research directions.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Polymer Science
Suguna Perumal, Raji Atchudan, Wonmok Lee
Summary: This review discusses the self-assembly of amphiphilic polymers into micelles (polymeric nanoparticles) and their importance in bio-applications. Micelles, with their unique properties, size, shape, and biocompatibility, enhance drug loading and target release, making them a research focus in the field of biomedicine.
Article
Pharmacology & Pharmacy
Bence Sipos, Ildiko Csoka, Maria Budai-Szucs, Gabor Kozma, Daniel Berkesi, Zoltan Konya, Gyorgy Tibor Balogh, Gabor Katona
Summary: The study successfully formulated a novel dexamethasone-loaded mixed polymeric micelle-based drug delivery system, focusing on the promising nose-to-brain pathway for treating central nervous system diseases.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Kedong Liu, Yun Chen, Dutao Yang, Yanfei Cai, Zhaoqi Yang, Jian Jin
Summary: Developing a hybrid micelle platform for oral drug delivery, with the ability to overcome both mucus permeation and epithelium absorption barriers, was investigated in this study. The optimized hybrid micelle exhibited excellent mucus and villi penetration capabilities, as well as enhanced cellular uptake. The results also indicated the involvement of the retrograde pathway in the intracellular transport and transcytosis delivery of the hybrid micelles.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biotechnology & Applied Microbiology
Annu, Ali Sartaj, Zufika Qamar, Shadab Md, Nabil A. Alhakamy, Sanjula Baboota, Javed Ali
Summary: The blood-brain barrier hinders the delivery of therapeutic molecules to the brain, but nanotechnology, specifically the use of polymeric nanoparticles, shows great potential in overcoming this barrier and targeting therapeutics to the brain, improving intervention for CNS disorders.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Genada Sinani, Meltem Ezgi Durgun, Erdal Cevher, Yildiz Ozsoy
Summary: Nucleic acids can regulate gene expression specifically and have huge potential in disease prevention and treatment. However, their clinical translation is challenging due to rapid clearance, low stability, and limited cellular uptake. Polymeric micelles have emerged as suitable delivery vehicles for nucleic acids, with their versatile structures and ability to overcome barriers and enhance therapeutic efficacy. Various strategies, such as stimuli-sensitive groups and specific ligands, can be used to improve delivery, targeting, and cellular uptake of nucleic acids. Additionally, polymeric micelles can deliver both chemotherapeutic drugs and nucleic acid therapeutics simultaneously, achieving synergistic combination treatment.
Review
Chemistry, Multidisciplinary
Weisen Zhang, Ami Mehta, Ziqiu Tong, Lars Esser, Nicolas H. Voelcker
Summary: Polymeric nanoparticles have shown great potential in overcoming the blood-brain barrier for effective drug delivery, with their unique properties offering high tunability and ease of synthesis. Careful analysis of their performance in transporting drugs across the blood-brain barrier is essential for successful drug delivery to the central nervous system.
Article
Materials Science, Multidisciplinary
Ivana Jarak, Miguel Pereira-Silva, Ana Claudia Santos, Francisco Veiga, Horacio Cabral, Ana Figueiras
Summary: PMs are efficient NA delivery platforms that can manipulate gene expression and have enormous potential for treating life-threatening diseases. The facile manipulation of polymeric building blocks allows for tuning crucial parameters for NA protection and targeted delivery.
APPLIED MATERIALS TODAY
(2021)
Article
Materials Science, Multidisciplinary
Kalipada Manna, Priyapratim Patra, Arpita Roy, Rakesh Kumar Roy, Krishna Chaitanya Sunka, Santanu Dhara, Niladri Patra, Sagar Pal
Summary: Biopolymeric micelles derived from bioinspired amphiphilic polymers have attracted attention as carriers for hydrophobic drugs. In this study, a hydrophobic monomer was synthesized and grafted onto a hydrophilic polymer backbone to obtain an amphiphilic copolymer. The copolymer showed controlled polymerization and pH-responsive reversible micellization behavior. The micelle formed from the copolymer was able to uptake and release a hydrophobic drug in a controlled manner.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Ellis Nelissen, Melissa Schepers, Laura Ponsaerts, Sebastien Foulquier, Annelies Bronckaers, Tim Vanmierlo, Peter Sandner, Jos Prickaerts
Summary: Vascular cognitive impairment (VCI) is a neurodegenerative disorder characterized by a vascular component, involving decreased cerebral blood flow, white matter lesions, endothelial dysfunction, and blood-brain barrier impairments. Oxidative stress and inflammation are major underlying mechanisms. Modulation of soluble guanylate cyclase (sGC) activity can improve vascular and neural function, and has shown efficacy in cardiovascular diseases.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Sabna Kotta, Hibah Mubarak Aldawsari, Shaimaa M. Badr-Eldin, Anroop B. Nair, Y. T. Kamal
Summary: Polymeric micelles (PMs) have shown significant progress in drug delivery applications due to their robust core-shell structure and ability to solubilize hydrophobic drugs. This review presents the recent advances and understandings of PMs, including preparation methods, applications, and tumor-targeted delivery.
Article
Geriatrics & Gerontology
Christina Hoyer-Kimura, Meredith Hay, John P. Konhilas, Helena W. Morrison, Methawasin Methajit, Joshua Strom, Robin Polt, Victoria Salcedo, Joshua P. Fricks, Anjna Kalya, Paulo W. Pires
Summary: It is well known that decreased brain blood flow, increased reactive oxygen species production, and pro-inflammatory mechanisms accelerate neurodegenerative disease progressions. This study demonstrates that treatment with the novel drug PNA5 can reverse cognitive deficits, decrease ROS production, and inhibit inflammatory cytokine production, suggesting its potential as an effective therapy for treating and preventing VCID.
Article
Immunology
Xiu-xiu Liu, Lin Yang, Ling-xiao Shao, Yang He, Gang Wu, Yu-huan Bao, Nan-nan Lu, Dong-mei Gong, Ya-ping Lu, Tian-tian Cui, Ning-he Sun, Dan-yang Chen, Wei-xing Shi, Kohji Fukunaga, Hong-shan Chen, Zhong Chen, Feng Han, Ying-mei Lu
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Biotechnology & Applied Microbiology
Nopparat Suthprasertporn, Nopparada Mingchinda, Kohji Fukunaga, Wipawan Thangnipon
Article
Biochemistry & Molecular Biology
Yasushi Yabuki, Kazuya Matsuo, Ichiro Kawahata, Naoya Fukui, Tomohiro Mizobata, Yasushi Kawata, Yuji Owada, Norifumi Shioda, Kohji Fukunaga
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Ichiro Kawahata, Kohji Fukunaga
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Dian Yuan, An Cheng, Ichiro Kawahata, Hisanao Izumi, Jing Xu, Kohji Fukunaga
Summary: SAK3, like donepezil, shows significant effects in improving cognitive and emotional behaviors, as well as reducing oxidative stress levels in OBX mice. The antioxidative effects of SAK3 are similar to those of donepezil, suggesting they are among the neuroprotective mechanisms in AD pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yifei Wang, Yasuharu Shinoda, An Cheng, Ichiro Kawahata, Kohji Fukunaga
Summary: The research revealed that the interaction between FABP5 and α Syn can lead to mitochondrial dysfunction in neuronal cells, increasing the risk of PD development.
Article
Medicine, Research & Experimental
Dan-Yang Chen, Ning-He Sun, Xiang Chen, Jun-Jie Gong, Song-Tao Yuan, Zi-Zhong Hu, Nan-Nan Lu, Jakob Korbelin, Kohji Fukunaga, Qing-Huai Liu, Ying-Mei Lu, Feng Han
Summary: Semaphorin 3G plays a crucial role in vascular remodeling and improvement of ischemic retinopathy by enhancing healthy vascular network formation and promoting diseased vasculature regression. Loss of Sema3G exacerbates pathological angiogenesis in retinal vasculature. Sema3G coordinates the functional interaction between beta-catenin and VE-cadherin, leading to increased beta-catenin stability and aiding in vascular remodeling.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Qingyun Guo, Ichiro Kawahata, Tomohide Degawa, Yuri Ikeda-Matsuo, Meiling Sun, Feng Han, Kohji Fukunaga
Summary: The study demonstrates that FABPs may exacerbate infarct volumes after ischemic stroke, and inhibiting FABPs can alleviate ischemic injury. MF6 inhibits FABPs and reduces inflammation-associated prostaglandin E-2 levels, potentially serving as a neuroprotective therapy for ischemic stroke.
Article
Multidisciplinary Sciences
Andrew C. Yang, Fabian Kern, Patricia M. Losada, Maayan R. Agam, Christina A. Maat, Georges P. Schmartz, Tobias Fehlmann, Julian A. Stein, Nicholas Schaum, Davis P. Lee, Kruti Calcuttawala, Ryan T. Vest, Daniela Berdnik, Nannan Lu, Oliver Hahn, David Gate, M. Windy McNerney, Divya Channappa, Inma Cobos, Nicole Ludwig, Walter J. Schulz-Schaeffer, Andreas Keller, Tony Wyss-Coray
Summary: This study found that patients with COVID-19 exhibited widespread cellular perturbations in the brain, including the relay of peripheral inflammation into the brain by choroid plexus barrier cells and infiltration of peripheral T cells. Additionally, COVID-19 affected synaptic signaling of upper-layer excitatory neurons linked to cognitive function.
Article
Multidisciplinary Sciences
Zurine De Miguel, Nathalie Khoury, Michael J. Betley, Benoit Lehallier, Drew Willoughby, Niclas Olsson, Andrew C. Yang, Oliver Hahn, Nannan Lu, Ryan T. Vest, Liana N. Bonanno, Lakshmi Yerra, Lichao Zhang, Nay Lui Saw, J. Kaci Fairchild, Davis Lee, Hui Zhang, Patrick L. McAlpine, Kevin Contrepois, Mehrdad Shamloo, Joshua E. Elias, Thomas A. Rando, Tony Wyss-Coray
Summary: Research shows that physical exercise can lead to the production of anti-inflammatory factors in the blood plasma of mice, which can reduce neuroinflammation, particularly in the hippocampus, and also increase in patients with cognitive impairment.
Article
Multidisciplinary Sciences
Tal Iram, Fabian Kern, Achint Kaur, Saket Myneni, Allison R. Morningstar, Heather Shin, Miguel A. Garcia, Lakshmi Yerra, Robert Palovics, Andrew C. Yang, Oliver Hahn, Nannan Lu, Steven R. Shuken, Michael S. Haney, Benoit Lehallier, Manasi Iyer, Jian Luo, Henrik Zetterberg, Andreas Keller, J. Bradley Zuchero, Tony Wyss-Coray
Summary: Recent understanding of how the systemic environment impacts lifelong brain development has led to interventions aimed at slowing brain ageing. This study discovered that infusing young cerebrospinal fluid (CSF) into aged brains improves memory function and promotes the proliferation and differentiation of oligodendrocyte progenitor cells (OPCs). The researchers identified serum response factor (SRF) as a mediator of OPC proliferation in response to young CSF, and fibroblast growth factor 17 (Fgf17) as a key target for restoring oligodendrocyte function in the ageing brain.
Review
Biochemistry & Molecular Biology
Qingyun Guo, Ichiro Kawahata, An Cheng, Wenbin Jia, Haoyang Wang, Kohji Fukunaga
Summary: Stroke is a leading cause of death and disability worldwide, but effective neuroprotective therapies for ischemic stroke patients are lacking. Lipids play important roles in the pathogenesis of neurological diseases, and fatty acid-binding proteins (FABPs) have been found to be involved in neurodegenerative diseases. However, FABPs' roles in ischemic stroke have received comparatively little attention. In this review, we summarize the literature on the associations between FABPs and ischemia and propose potential therapeutic targets for ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Yimin Jiang, Yunshi Lin, Yuhang Tan, Xinkai Shen, Meihua Liao, Huan Wang, Nannan Lu, Feng Han, Nenggui Xu, Chunzhi Tang, Juxian Song, Rongrong Tao
Summary: In this study, the efficacy and mechanism of electroacupuncture (EA) in improving cerebrovascular impairment in Alzheimer's disease (AD) were investigated. The results showed that EA could alleviate neurological disorders and promote cerebrovascular repair in AD mice. EA attenuated cerebral microvascular degeneration by modulating endothelial cell viability and injury, leading to the reversal of Aβ deposits and neural damage in AD mice. These findings provide strong evidence to support EA as a potential nonpharmacological therapy for cerebrovascular impairment in AD.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Correction
Multidisciplinary Sciences
Tal Iram, Fabian Kern, Achint Kaur, Saket Myneni, Allison R. Morningstar, Heather Shin, Miguel A. Garcia, Lakshmi Yerra, Robert Palovics, Andrew C. Yang, Oliver Hahn, Nannan Lu, Steven R. Shuken, Michael S. Haney, Benoit Lehallier, Manasi Iyer, Jian Luo, Henrik Zetterberg, Andreas Keller, J. Bradley Zuchero, Tony Wyss-Coray
Article
Biochemistry & Molecular Biology
Wenbin Jia, Ichiro Kawahata, An Cheng, Takuya Sasaki, Toshikuni Sasaoka, Kohji Fukunaga
Summary: We confirmed that the FABP3 inhibitor, MF1, successfully reduces nicotine-induced conditioned place preference in mice. MF1 treatment decreased CPP scores in a dose-dependent manner by inhibiting the activation of CaMKII and ERK in the nucleus accumbens and hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)