Review
Cell Biology
Rongyu Zhang, Jinghong Chen, Saiyang Wang, Wenlong Zhang, Quan Zheng, Rong Cai
Summary: Ferroptosis is an iron-dependent form of regulated cell death associated with processes including iron overload, lipid peroxidation, and dysfunction of cellular antioxidant systems. Recent studies have shown its close relationship with cancer progression, including EMT, cancer angiogenesis, invasion, and metastasis. The signaling pathways activated during ferroptosis and cancer metastasis interweave, and ferroptosis may serve as a potential predictor of cancer grades and prognoses.
Article
Biochemistry & Molecular Biology
Lavinia Raimondi, Alessia Gallo, Nicola Cuscino, Angela De Luca, Viviana Costa, Valeria Carina, Daniele Bellavia, Matteo Bulati, Riccardo Alessandro, Milena Fini, Pier Giulio Conaldi, Gianluca Giavaresi
Summary: This study reveals a novel role of miR-CT3 in regulating tumor angiogenesis and progression in osteosarcoma cells, as well as its association with the modulation of epithelial-mesenchymal transition proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yan Zhao, Jiajia Gao, Xiufeng Xie, Peng Nan, Fang Liu, Yulin Sun, Xiaohang Zhao
Summary: The study demonstrated that BACH1 is overexpressed in ESCC tissues, associated with poor prognosis. BACH1 enhances migration and invasion in ESCC, promotes EMT and angiogenesis, and may serve as a promising therapeutic target or molecular marker in ESCC.
Article
Medicine, Research & Experimental
Cho-Won Kim, Hong Kyu Lee, Min-Woo Nam, Gabsang Lee, Kyung-Chul Choi
Summary: This study found that KiSS1 overexpression increases the growth and migration of metastatic prostate cancer cells, as well as promoting tumor metastasis and angiogenesis. These findings highlight the critical role of KiSS1 in prostate cancer progression.
Article
Oncology
Yao Zhao, Chenchen Cai, Miaomiao Zhang, Lubing Shi, Jiwei Wang, Haoliang Zhang, Ping Ma, Shibao Li
Summary: The study revealed that Ephrin-A2 promotes prostate cancer metastasis by enhancing angiogenesis and promoting EMT, suggesting it may be a potential therapeutic target in metastatic prostate cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Bo Kou, Xin-Di Wang, Xiao-Peng Sun, Qin Qi, Ming Yang, Yan-Ning Yun, Jin-Song Zhou, Wei Liu
Summary: The study reveals that LKB1 inhibits proliferation, metastasis, and angiogenesis, and reverses EMT in thyroid cancer through upregulation of SIK1. LKB1 overexpression can suppress cell growth, migration, invasion, and tube formation in vitro and inhibit tumorigenicity and angiogenesis in vivo. LKB1 is a potential therapeutic target for the treatment of thyroid cancer.
Review
Biochemistry & Molecular Biology
Ghader Babaei, Negin Raei, Attabak Toofani Milani, Shiva Gholizadeh-Ghaleh Aziz, Nima Pourjabbar, Faezeh Geravand
Summary: The miR-200 family is involved in various processes related to cancer metastasis, including cancer stem cells, EMT, angiogenesis, and anoikis. Understanding the molecular mechanisms associated with metastasis in which the miR-200 family is involved can be effective in treating metastatic cancers.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Oncology
Giovanni Di Maira, Beatrice Foglia, Lucia Napione, Cristian Turato, Marina Maggiora, Salvatore Sutti, Erica Novo, Maria Alvaro, Riccardo Autelli, Sebastiano Colombatto, Federico Bussolino, Patrizia Carucci, Silvia Gaia, Chiara Rosso, Alessandra Biasiolo, Patrizia Pontisso, Elisabetta Bugianesi, Emanuele Albano, Fabio Marra, Maurizio Parola, Stefania Cannito
Summary: This study investigated the role of Oncostatin M (OSM), a pleiotropic cytokine of the IL-6 family, in the development and progression of hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH). The results showed that OSM was selectively overexpressed in HCC cells of NAFLD/NASH patients and correlated with tumor grade and survival rate. Cell culture experiments and mouse models further demonstrated that OSM upregulation contributed to HCC progression by inducing epithelial-to-mesenchymal transition, increased invasiveness of cancer cells, and angiogenesis. Therefore, OSM may serve as a prognostic marker and a potential therapeutic target for HCC in NAFLD/NASH patients.
JOURNAL OF PATHOLOGY
(2022)
Article
Cell Biology
Fan Li, Huizhi Sun, Yihui Yu, Na Che, Jiyuan Han, Runfen Cheng, Nan Zhao, Yuhong Guo, Chongbiao Huang, Danfang Zhang
Summary: In this study, it was found that RIPK1-dependent necroptosis promoted vasculogenic mimicry (VM) formation in triple-negative breast cancer (TNBC). The activation of RIPK1/p-AKT/eIF4E signaling pathway played a role in this process. Furthermore, eIF4E promoted epithelial-mesenchymal transition (EMT) and MMP2 expression and activity, contributing to VM formation. The findings suggest potential therapeutic targets for TNBC through necroptosis-mediated VM.
CELL DEATH & DISEASE
(2023)
Review
Oncology
Marie-Anne Goyette, Jean-Francois Cote
Summary: Metastasis is a complex process involving the acquisition of specific traits by cancer cells and the cooperation of non-neoplastic cells in the stroma. AXL receptor tyrosine kinase plays a crucial role in multiple steps of the metastatic cascade and contributes to deregulation of the tumor microenvironment. Inhibition of AXL has been shown to be beneficial for the treatment of metastatic cancers, but other roles of AXL in cancer progression are still being explored.
Review
Cell Biology
Jia-Nan Cheng, Yi-Xiao Yuan, Bo Zhu, Qingzhu Jia
Summary: MDSCs play a crucial role in regulating immune responses, promoting tumor progression, and predicting therapeutic outcomes. Targeting MDSCs could potentially improve treatment efficacy in cancer therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Elise Pretzsch, Volker Heinemann, Sebastian Stintzing, Andreas Bender, Shuo Chen, Julian Walter Holch, Felix Oliver Hofmann, Haoyu Ren, Florian Boesch, Helmut Kuechenhoff, Jens Werner, Martin Konrad Angele
Summary: Despite advances in therapy, the survival rate for metastatic colorectal cancer (CRC) patients remains low. Proper risk stratification is necessary to avoid inadequate or excessive treatment. This study analyzed the prognostic effect of EMT-related genes in stage IV CRC patients and found that their prognostic relevance may depend on the stage of cancer.
Article
Medicine, Research & Experimental
Feng Bai, Li-Han Zhang, Xiong Liu, Chuying Wang, Chenglong Zheng, Jianping Sun, Min Li, Wei-Guo Zhu, Xin-Hai Pei
Summary: The study reveals a positive correlation between BRCA1 and GATA3 expression in human breast cancers. Depletion of BRCA1 stimulates methylation of GATA3 promoter, repressing GATA3 transcription. Additionally, GATA3 deficiency induces poorly-differentiated mammary tumors with activated EMT and increased metastatic potential.
Review
Oncology
Raneem Y. Hammouz, Damian Kolat, Zaneta Kaluzinska, Elzbieta Pluciennik, Andrzej K. Bednarek
Summary: In cells with invasive capabilities, altered proteins contribute to cancer invasion and metastasis. MicroRNAs play key roles in bladder cancer metastasis and angiogenesis, serving as potential therapeutic targets or diagnostic markers.
Article
Oncology
Tetsuro Watabe, Kazuki Takahashi, Kristian Pietras, Yasuhiro Yoshimatsu
Summary: Tumor cells evolve through interactions with various cell types in the tumor microenvironment. Endothelial cells (ECs), as important players in tumor angiogenesis, also contribute to tumor progression and metastasis through a process called endothelial-mesenchymal transition (EndoMT). EndoMT, mediated by cytokines like TGF-beta, is involved in multiple steps of tumor progression and can be targeted as a therapeutic strategy.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Liqiang Chen, Chendong Liu, Yucheng Xiang, Jiayan Lyu, Zhou Zhou, Tao Gong, Huile Gao, Lian Li, Yuan Huang
Summary: A new strategy for targeting the endoplasmic reticulum (ER) is proposed in this study, which utilizes homologous cancer cell membrane-coated nanoparticles (HCC@NP) to overcome the limited accumulation and rapid exocytosis of nanodrugs in the ER. The strategy achieves high-efficiency and long-term ER retention, inducing potent immunogenic cell death and promoting anti-tumor immunity.
Review
Chemistry, Multidisciplinary
Shaojun Peng, Fengfeng Xiao, Meiwan Chen, Huile Gao
Summary: Cancer immunotherapy has made great progress in the past decades, but challenges such as low patient response rates and potential immune-related adverse events persist. Tumor-microenvironment (TME)-responsive nanomedicine has shown promise in amplifying immune responses in a specific and localized manner within tumor tissue, leading to increased patient response rates and reduced immune-related side effects.
Article
Pharmacology & Pharmacy
Yang Zhou, Fan Tong, Weilong Gu, Siqin He, Xiaotong Yang, Jiamei Li, Yue-Dong Gao, Huile Gao
Summary: By utilizing a modified nanocarrier, this study proposes a sequentially responsive platform to enhance photodynamic therapy and overcome hypoxia resistance, leading to improved anti-tumor outcomes.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Xueqin He, Xiaorong Wang, Lianyi Yang, Zhihang Yang, Wenqi Yu, Yazhen Wang, Rui Liu, Meiwan Chen, Huile Gao
Summary: This study established a drug co-delivery system for Alzheimer's disease that efficiently targets the neurovascular unit in AD lesions and specifically releases drugs in astrocytes in response to high levels of ROS. It significantly improves cognition, reduces beta-amyloid plaques, alleviates neurotoxicity, and inhibits neuroinflammation in AD mice.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Yihan Wu, Jingjing Li, Xuemei Zhong, Jinfeng Shi, Yanfen Cheng, Chenglin He, Jiaxin Li, Liang Zou, Chaomei Fu, Meiwan Chen, Jinming Zhang, Huile Gao
Summary: In this study, a pH-sensitive supramolecular nanosystem was designed for co-delivery of Ce6 and TPL, exhibiting ideal drug release characteristics and enhanced cellular uptake capacity. TPL+Ce6/NPs showed significant synergistic chemo-photodynamic therapeutic effects in vitro and in vivo, with lower systemic toxicity in tumor-bearing mice.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Engineering, Biomedical
Heng Mei, Shengsheng Cai, Dennis Huang, Huile Gao, Jun Cao, Bin He
Summary: This review discusses strategies to enhance drug delivery and release of carrier-free nanodrugs for improved cancer therapy. Optimizing the intrinsic physicochemical properties and external modification are key methods.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Mingming Han, Jingjing Yao, Jiwu Huang, Yan Tang, Xianwen Wu, Bingan Lu, Jiang Zhou
Summary: Aqueous rechargeable Zn//MnO2 batteries are a promising candidate for future energy storage systems due to their economic and environmental advantages. However, poor reaction kinetics and capacity degradation hinder the performance of Zn//MnO2 batteries. This study demonstrates that defects engineering and phase transformation can enhance ion/charge transfer kinetics and structural stability, leading to a high discharge capacity of 285 mAh/g and capacity retention of 81% after 500 cycles in the aqueous Zn//A-MnO2 system.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Rui Liu, Cong Luo, Zhiqing Pang, Jinming Zhang, Shaobo Ruan, Meiying Wu, Lei Wang, Tao Sun, Nan Li, Liang Han, Jinjin Shi, Yuanyu Huang, Weisheng Guo, Shaojun Peng, Wenhu Zhou, Huile Gao
Summary: Decades have passed since the approval of the first nanoparticles-based medicine for human cancer treatment, and research and development in nanoparticles for drug delivery have been continuing. Today, there have been significant advancements in nanoparticles, including liposomes, solid lipid nanoparticles, inorganic nanoparticles, micelles, nanovaccines, and nano-antibodies. These nanoparticles have shown great potential in the treatment and diagnosis of challenging diseases such as cancer and neurodegenerative diseases, making them promising drug carriers and therapeutic agents in the future.
CHINESE CHEMICAL LETTERS
(2023)
Review
Pharmacology & Pharmacy
Zhaofeng Li, Wei Zhang, Zhong Zhang, Huile Gao, Yi Qin
Summary: Bone metastases are recognized as common metastases that affect patient quality of life and survival. Nanomedicine, as a new treatment strategy, shows great potential for the treatment of bone metastases.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Chemistry, Multidisciplinary
Xiaotong Yang, Wenqin Yang, Xue Xia, Ting Lei, Zhihang Yang, Wenfeng Jia, Yang Zhou, Guo Cheng, Huile Gao
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease with no effective treatment. In this study, a multifunctional nanocarrier was developed to deliver beta-site precursor protein cleaving enzyme-1 (BACE1) siRNA and rapamycin into the brain via intranasal administration. The results showed that this nanocarrier significantly improved the cognitive ability of transgenic AD mice.
Review
Chemistry, Multidisciplinary
Kamil G. Gareev, Denis S. Grouzdev, Veronika V. Koziaeva, Nikita O. Sitkov, Huile Gao, Tatiana M. Zimina, Maxim Shevtsov
Summary: Biomimetic nanomaterials (BNMs) are functional materials that mimic the structure of natural prototypes. This review provides an overview of the classification and applications of BNMs.
Review
Pharmacology & Pharmacy
Jide He, Zenan Liu, Xuehua Zhu, Haizhui Xia, Huile Gao, Jian Lu
Summary: This article reviews the research progress of ultrasound-mediated microbubble cavitation in the treatment of solid tumors, emphasizing its potential to reverse chemoresistance, improve efficacy sensitization response, and reduce adverse side effects.
Review
Chemistry, Analytical
Tatiana M. Zimina, Nikita O. Sitkov, Kamil G. Gareev, Viacheslav Fedorov, Denis Grouzdev, Veronika Koziaeva, Huile Gao, Stephanie E. Combs, Maxim Shevtsov
Summary: This review summarizes the applications, properties, and advantages of synthetic and biogenic magnetic nanoparticles in oncological theranostics. Biogenic particles exhibit lower toxicity and better in vivo application potential.
Article
Pharmacology & Pharmacy
Zhihang Yang, Yufan Du, Lei Lei, Xue Xia, Xiaorong Wang, Fan Tong, Yuan Li, Huile Gao
Summary: In this study, a human serum albumin-based co-delivery system of IBR and HCQ was developed for the treatment of glioma. The system improved the bioavailability of IBR, enhanced the sensitivity of glioma to IBR, and inhibited the prosurvival autophagy induced by IBR through HCQ. The in vitro and in vivo experiments demonstrated the cytotoxicity and prolonged survival time of IBR&HCQ HSA NPs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Tina Sepasi, Farhad Bani, Reza Rahbarghazi, Abbas Ebrahimi-Kalan, Mohammad-Reza Sadeghi, Seyedeh Zahra Alamolhoda, Amir Zarebkohan, Tahereh Ghadiri, Huile Gao
Summary: This study successfully designed an efficient biocarrier for brain gene delivery using CDX-modified chitosan nanoparticles, leading to the expression of the target protein. However, these nanoparticles also showed distribution in other organs.