Review
Gastroenterology & Hepatology
Noel Pin-Vieito, Manuel Puga, Daniel Fernandez-de-Castro, Joaquin Cubiella
Summary: FIT is widely used as a biomarker for colorectal cancer diagnosis and plays a crucial role in screening and surveillance. This review summarizes the diagnostic efficacy of FIT in symptomatic patients and post-adenoma resection, as well as discusses the potential impact of FIT strategies on healthcare resources and CRC prognosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Sara G. Ribe, Edoardo Botteri, Magnus Loberg, Kristin R. Randel, Mette Kalager, Jens Aksel Nilsen, Elisabeth H. Gulichsen, Oyvind Holme
Summary: This study investigated the impact of time interval between faecal immunochemical testing (FIT) cycles on the detection rate of colorectal cancer (CRC) and advanced neoplasia (AN). The results showed that although the detection rates of CRC and AN increased with increasing time interval between FITs, individuals who had undetectable faecal haemoglobin (f-Hb) at the first screening round had a substantially lower risk of CRC at the next screening round compared to individuals with detectable f-Hb.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Medical Laboratory Technology
Gavin R. C. Clark, Robert J. C. Steele, Callum G. Fraser
Summary: Women are at a disadvantage in colorectal cancer screening due to lower faecal haemoglobin concentrations, leading to poorer outcomes. Risk scoring strategies that consider sex have not been extensively tested or introduced. Governments and agencies should prioritize allocating resources to implement simple strategies, such as using different haemoglobin thresholds, to achieve equal positivity in both sexes.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Review
Medicine, General & Internal
Esmee J. Grobbee, Pieter Ha Wisse, Eline H. Schreuders, Aafke van Roon, Leonie van Dam, Ann G. Zauber, Iris Lansdorp-Vogelaar, Wichor Bramer, Sarah Berhane, Jonathan J. Deeks, Ewout W. Steyerberg, Monique E. van Leerdam, Manon Cw Spaander, Ernst J. Kuipers
Summary: FIT is superior to gFOBT in detecting advanced colorectal neoplasia and colorectal cancer in average-risk individuals. The specificity of both tests was similar, while the sensitivity of FIT was significantly higher than gFOBT at pre-specified specificities.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Multidisciplinary Sciences
Miriam P. van der Meulen, Esther Toes-Zoutendijk, Manon C. W. Spaander, Evelien Dekker, Johannes M. G. Bonfrer, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, M. F. van Velthuysen, Maarten G. J. Thomeer, Harriet van Veldhuizen, Harry J. de Koning, Iris Lansdorp-Vogelaar, Monique E. van Leerdam
Summary: The participation rate in FIT screening is lower for individuals with a lower socioeconomic status (SES), but they have a higher detection rate for advanced neoplasia. Screening has the potential to reduce health inequalities in CRC mortality.
Article
Medicine, General & Internal
Lasse Kaalby, Ulrik Deding, Issam Al-Najami, Gabriele Berg-Beckhoff, Thomas Bjorsum-Meyer, Tinne Laurberg, Aasma Shaukat, Robert J. C. Steele, Anastasios Koulaouzidis, Morten Rasmussen, Morten Kobaek-Larsen, Gunnar Baatrup
Summary: New research suggests that faecal haemoglobin concentration (f-Hb) can indicate the presence of serious diseases not related to colorectal cancer (CRC). This study found an association between increasing f-Hb and the risk of mortality, as well as an increased risk of dying from respiratory disease, cardiovascular disease, and other cancers. f-Hb may be a potential biomarker for non-CRC diseases.
Article
Public, Environmental & Occupational Health
Johanna Wangmar, Yvonne Wengstrom, Anna Jervaeus, Kaisa Fritzell
Summary: The acceptability of colorectal cancer screening procedures is crucial for the success of screening programs. This study explored how individuals experience CRC screening, finding that experiences vary from having no worries to experiencing bothersome emotions, logistical concerns, inconsistent information, and unmet expectations. Improving patient experiences may involve using one-sample FITs, optimizing bowel preparation for colonoscopies, and delivering clear information and emotional support at the right time.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Oncology
Anton Gies, Tobias Niedermaier, Elizabeth Alwers, Thomas Hielscher, Korbinian Weigl, Thomas Heisser, Petra Schrotz-King, Michael Hoffmeister, Hermann Brenner
Summary: This study evaluated the performance of nine fecal immunochemical tests in screening colonoscopy participants, with differences in diagnostic performance observed by sex and age. Females consistently showed lower sensitivities and higher specificities than males, with higher negative predictive values. A negative FIT was found to be less reliable in ruling out AN among men and older participants than among women and younger participants.
Article
Gastroenterology & Hepatology
Manuel Zorzi, Jessica Battagello, Kevin Selby, Giulia Capodaglio, Susanna Baracco, Silvia Rizzato, Enrico Chinellato, Stefano Guzzinati, Massimo Rugge
Summary: A study conducted in the Veneto region of Italy found that the risk of colorectal cancer mortality is significantly higher among individuals who do not undergo colonoscopy after a positive FIT result, highlighting the importance of increasing compliance in this high-risk population.
Article
Public, Environmental & Occupational Health
Matthew T. Keys, Miquel Serra-Burriel, Natalia Martinez-Lizaga, Maria Pellise, Francesc Balaguer, Ariadna Sanchez, Enrique Bernal-Delgado, Antoni Castells
Summary: The study found that FIT-based organized colorectal cancer screening in Spain was associated with a reduction in population colorectal cancer mortality. No differences in outcome trends were observed between exposed and control provinces in the 7 years prior to screening implementation. Two years after implementation, exposed provinces experienced an increase in colorectal cancer incidence, followed by a decrease in mortality rates after 7 years.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Oncology
Thuy Ngan Tran, Marc Peeters, Sarah Hoeck, Guido van Hal, Sharon Janssens, Harlinde de Schutter
Summary: Interval cancer after faecal immunochemical test (FIT) screening is a critical issue in colorectal cancer (CRC) screening. This study identified factors associated with FIT-ICs and explored the impact of lowering FIT cut-off or shortening screening interval. The results showed that FIT-ICs were more common in women, older age, right-sided location, advanced stage, and high grade. Lowering the FIT cut-off or shortening the screening interval would have minimal impact on FIT-ICs.
BRITISH JOURNAL OF CANCER
(2022)
Article
Medical Laboratory Technology
Sally C. Benton, Carolyn Piggott, Zahida Zahoor, Shane O'Driscoll, Callum G. Fraser, Nigel D'Souza, Michelle Chen, Theo Georgiou Delisle, Muti Abulafi
Summary: This study assessed the comparability of faecal haemoglobin concentrations obtained with four quantitative FIT systems at different thresholds. The results showed differences between systems at lower thresholds, highlighting the need for further understanding of their clinical impact and efforts to minimize these differences.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Oncology
Andrea Cruz, Carla M. Carvalho, Alexandra Cunha, Anais Crespo, Agueda Iglesias, Laura Garcia-Nimo, Paulo P. Freitas, Joaquin Cubiella
Summary: The study aimed to analyze the diagnostic value of six biomarkers in stool samples of patients with CRC, advanced adenomas, other lesions, and healthy individuals. Results showed that Hb and M2-PK levels were increased in CRC patients compared to controls, suggesting a potential as fecal diagnostic biomarkers for CRC detection.
Review
Multidisciplinary Sciences
Lina Choe, Jerrald Lau, Larry Teck-Seng Yip, Guowei Kim, Ker-Kan Tan
Summary: There is limited evidence to support upper gastrointestinal screening in all FIT-positive patients following a colonoscopy. However, opportunistic OGD may have a role in this patient group.
Review
Medicine, General & Internal
Karen N. Barnett, Gavin R. C. Clark, Robert J. C. Steele, Callum G. Fraser
Summary: Elevated faecal haemoglobin concentration is associated with increased mortality and various chronic conditions, showing promise as a biomarker for chronic disease and multimorbidity. Longitudinal data-linkage methodology is needed to further explore its potential in identifying individuals at risk of developing chronic diseases.
Article
Public, Environmental & Occupational Health
Carrie Klabunde, Johannes Blom, Jean-Luc Bulliard, Montse Garcia, Lea Hagoel, Verna Mai, Julietta Patnick, Heather Rozjabek, Carlo Senore, Sven Tornberg
JOURNAL OF MEDICAL SCREENING
(2015)
Article
Surgery
Hanna Ribbing Wilen, Per-Olof Nystrom, Leif Torkvist, Johannes Blom
EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
(2016)
Article
Public, Environmental & Occupational Health
Deborah Saraste, Anna Martling, Per J. Nilsson, Johannes Blom, Sven Tornberg, Rolf Hultcrantz, Martin Janson
JOURNAL OF MEDICAL SCREENING
(2016)
Article
Public, Environmental & Occupational Health
D. Saraste, A. Martling, P. J. Nilsson, J. Blom, S. Tornberg, M. Janson
JOURNAL OF MEDICAL SCREENING
(2017)
Article
Public, Environmental & Occupational Health
Deborah Saraste, Daniel J. Ohman, Marika Sventelius, K. Miriam Elfstrom, Johannes Blom, Sven Tornberg
JOURNAL OF MEDICAL SCREENING
(2018)
Article
Public, Environmental & Occupational Health
Johannes Blom, Sven Tornberg
JOURNAL OF MEDICAL SCREENING
(2017)
Article
Gastroenterology & Hepatology
Hanna Ribbing Wilen, Johannes Blom, Jonas Hoijer, Rolf Hultcrantz
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Medicine, General & Internal
Beatrice Lauby-Secretan, Nadia Vilahur, Franca Bianchini, Neela Guha, Kurt Straif
NEW ENGLAND JOURNAL OF MEDICINE
(2018)
Review
Oncology
Jean-Luc Bulliard, Montse Garcia, Johannes Blom, Carlo Senore, Verna Mai, Carrie Klabunde
EUROPEAN JOURNAL OF CANCER
(2014)
Article
Public, Environmental & Occupational Health
Johannes Blom, Sini Kilpela Inen, Rolf Hultcrantz, Sven Tornberg
JOURNAL OF MEDICAL SCREENING
(2014)
Article
Gastroenterology & Hepatology
Hanna Ribbing Wilen, Johannes Blom, Jonas Hoijer, Gaya Andersson, Christian Lowbeer, Rolf Hultcrantz
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Public, Environmental & Occupational Health
Hanna Ribbing Wilen, Deborah Saraste, Johannes Blom
Summary: The gender-specific cut-off levels of fecal hemoglobin in the population-based Swedish regional colorectal cancer screening program resulted in higher detection rates of CRC in women, despite a minor increase in screening costs.
JOURNAL OF MEDICAL SCREENING
(2021)
Article
Gastroenterology & Hepatology
Jingru Yu, Erle Refsum, Lise M. Helsingen, Trine Folseraas, Alexander Ploner, Paulina Wieszczy, Ishita Barua, Henriette C. Jodal, Espen Melum, Magnus Loberg, Johannes Blom, Michael Bretthauer, Hans-Olov Adami, Mette Kalager, Weimin Ye
Summary: This study found significantly increased risks of hepato-pancreato-biliary cancers in PSC-IBD patients, highlighting the importance of periodic surveillance for these malignancies.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Hanna Ribbing Wilen, Deborah Saraste, Johannes Blom
Summary: In the population-based screening program in Stockholm-Gotland, the test sensitivity for colorectal cancer was found to be higher in women compared to men, while the rate of interval cancers did not show significant differences between genders.
JOURNAL OF MEDICAL SCREENING
(2022)