Article
Gastroenterology & Hepatology
Han-Mo Chiu, Grace Hsiao-Hsuan Jen, Ying-Wei Wang, Jean Ching-Yuan Fann, Chen-Yang Hsu, Ya-Chung Jeng, Amy Ming-Fang Yen, Sherry Yueh-Hsia Chiu, Sam Li-Sheng Chen, Wen-Feng Hsu, Yi-Chia Lee, Ming-Shiang Wu, Chien-Yuan Wu, Yann-Yuh Jou, Tony Hsiu-Hsi Chen
Summary: A large-scale population-based biennial FIT screening showed a significant 34% reduction in advanced-stage CRCs and a 40% reduction in death from CRC, with greater long-term effectiveness in the distal colon. The findings provide strong and consistent evidence-based policy support for sustainable population-based FIT organized service screening worldwide.
Article
Oncology
Sara G. Ribe, Edoardo Botteri, Magnus Loberg, Kristin R. Randel, Mette Kalager, Jens Aksel Nilsen, Elisabeth H. Gulichsen, Oyvind Holme
Summary: This study investigated the impact of time interval between faecal immunochemical testing (FIT) cycles on the detection rate of colorectal cancer (CRC) and advanced neoplasia (AN). The results showed that although the detection rates of CRC and AN increased with increasing time interval between FITs, individuals who had undetectable faecal haemoglobin (f-Hb) at the first screening round had a substantially lower risk of CRC at the next screening round compared to individuals with detectable f-Hb.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Gastroenterology & Hepatology
Noel Pin-Vieito, Manuel Puga, Daniel Fernandez-de-Castro, Joaquin Cubiella
Summary: FIT is widely used as a biomarker for colorectal cancer diagnosis and plays a crucial role in screening and surveillance. This review summarizes the diagnostic efficacy of FIT in symptomatic patients and post-adenoma resection, as well as discusses the potential impact of FIT strategies on healthcare resources and CRC prognosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Tytti Sarkeala, Martti Farkkila, Ahti Anttila, Marja Hyoty, Matti Kairaluoma, Tero Rautio, Markku Voutilainen, Sanni Helander, Maija Jantti, Milla Lehtinen, Lotta Patrikka, Nea Malila, Sirpa Heinavaara
Summary: The relaunched colorectal cancer screening programme with different cut-offs for men and women showed higher participation rates for women and different detection rates for CRC and advanced adenoma between genders. The results suggest that gender-specific protocols in organized CRC screening may lead to more effective outcomes.
Article
Gastroenterology & Hepatology
Szu-Min Peng, Wen-Feng Hsu, Ying-Wei Wang, Li-Ju Lin, Amy Ming-Fang Yen, Li-Sheng Chen, Yi-Chia Lee, Ming-Shiang Wu, Tony Hsiu-Hsi Chen, Han-Mo Chiu
Summary: A study in the Taiwanese Colorectal Cancer Screening Program found that subjects with negative colonoscopy after positive FIT who received subsequent FIT screening had a significantly lower risk of incident CRC, suggesting that scheduling subsequent FIT is important in reducing the risk of missed neoplasms and incident CRC in a national FIT screening program.
Article
Oncology
Lauro Bucchi, Silvia Mancini, Flavia Baldacchini, Alessandra Ravaioli, Orietta Giuliani, Rosa Vattiato, Federica Zamagni, Paolo Giorgi Rossi, Cinzia Campari, Debora Canuti, Enza Di Felice, Priscilla Sassoli de Bianchi, Stefano Ferretti, Nicoletta Bertozzi, Annibale Biggeri, Fabio Falcini
Summary: This study evaluated the effectiveness of a biennial FIT screening programme in reducing colorectal cancer incidence in a region of northern Italy. The study found consistent evidence of a causal relationship between the introduction of screening and a stable 28% decrease in annual colorectal cancer incidence after eight years.
BRITISH JOURNAL OF CANCER
(2022)
Review
Medicine, General & Internal
Esmee J. Grobbee, Pieter Ha Wisse, Eline H. Schreuders, Aafke van Roon, Leonie van Dam, Ann G. Zauber, Iris Lansdorp-Vogelaar, Wichor Bramer, Sarah Berhane, Jonathan J. Deeks, Ewout W. Steyerberg, Monique E. van Leerdam, Manon Cw Spaander, Ernst J. Kuipers
Summary: FIT is superior to gFOBT in detecting advanced colorectal neoplasia and colorectal cancer in average-risk individuals. The specificity of both tests was similar, while the sensitivity of FIT was significantly higher than gFOBT at pre-specified specificities.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Oncology
Edoardo Botteri, Geir Hoff, Kristin R. Randel, Oyvind Holme, Thomas de Lange, Tomm Bernklev, Eline Aas, Mona Berthelsen, Erik Natvig, Benedicte Kirkoen, Markus D. Knudsen, Ane S. Kvaerner, Anna L. Schult, Giske Ursin, Anita Jorgensen, Paula Berstad
Summary: This study assessed the participation rates of different population subgroups in colorectal cancer screening, and found that male gender, young age, low education and income, being retired or unemployed, living alone, being an immigrant, long driving time, and the use of certain drugs were associated with low participation. It was also found that fecal immunochemical testing (FIT) screening had more equal access compared to sigmoidoscopy screening.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Manuel Zorzi, Jessica Battagello, Kevin Selby, Giulia Capodaglio, Susanna Baracco, Silvia Rizzato, Enrico Chinellato, Stefano Guzzinati, Massimo Rugge
Summary: A study conducted in the Veneto region of Italy found that the risk of colorectal cancer mortality is significantly higher among individuals who do not undergo colonoscopy after a positive FIT result, highlighting the importance of increasing compliance in this high-risk population.
Article
Public, Environmental & Occupational Health
Sirpa Heinavaara, Andrea Gini, Tytti Sarkeala, Ahti Anttila, Harry de Koning, Iris Lansdorp-Vogelaar
Summary: This study modeled the cost-effectiveness of sex-specific FIT screening strategies in Finland and evaluated the optimal strategies. The results showed that annual FIT screening with a cut-off of 25μg/g for men aged 50-79 and with a cut-off of 10μg/g for women aged 55-69 was optimal. This strategy significantly reduced the incidence and mortality of colorectal cancer.
PREVENTIVE MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Anna Forsberg, Marcus Westerberg, Chris Metcalfe, Robert Steele, Johannes Blom, Lars Engstrand, Kaisa Fritzell, Mikael Hellstrom, Lars-Ake Levin, Christian Lowbeer, Andreas Pischel, Ulf Stromberg, Sven Tornberg, Yvonne Wengstrom, Anders Ekbom, Lars Holmberg, Rolf Hultcrantz
Summary: This study aimed to investigate the impact of once-only colonoscopy or two rounds of faecal immunochemical test screening on colorectal cancer mortality and incidence. The study found differences in the detection rates of colorectal cancer and advanced adenomas between the colonoscopy group and the faecal immunochemical test group, but both screening methods had a low number of adverse events.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Medical Laboratory Technology
Gavin R. C. Clark, Robert J. C. Steele, Callum G. Fraser
Summary: Women are at a disadvantage in colorectal cancer screening due to lower faecal haemoglobin concentrations, leading to poorer outcomes. Risk scoring strategies that consider sex have not been extensively tested or introduced. Governments and agencies should prioritize allocating resources to implement simple strategies, such as using different haemoglobin thresholds, to achieve equal positivity in both sexes.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Hilliene J. van de Schootbrugge-vandermeer, Arthur I. Kooyker, Pieter H. A. Wisse, Iris D. Nagtegaal, Hiltje A. Geuzinge, Esther Toes-Zoutendijk, Lucie de Jonge, Emilie C. H. Breekveldt, Anneke J. van Vuuren, Folkert J. van Kemenade, Christian R. B. Ramakers, Evelien Dekker, Iris Lansdorp-Vogelaar, Manon C. W. Spaander, Monique E. van Leerdam
Summary: This study assessed the risk of colorectal cancer (CRC) in FIT-positive individuals after a negative colonoscopy. The results showed that the risk of interval post-colonoscopy CRC (iPCCRC) was low in the first years after colonoscopy, but after 2.5 years, it was the same as the risk in FIT-negative individuals at 2 years.
Article
Oncology
Thuy Ngan Tran, Marc Peeters, Sarah Hoeck, Guido van Hal, Sharon Janssens, Harlinde de Schutter
Summary: Interval cancer after faecal immunochemical test (FIT) screening is a critical issue in colorectal cancer (CRC) screening. This study identified factors associated with FIT-ICs and explored the impact of lowering FIT cut-off or shortening screening interval. The results showed that FIT-ICs were more common in women, older age, right-sided location, advanced stage, and high grade. Lowering the FIT cut-off or shortening the screening interval would have minimal impact on FIT-ICs.
BRITISH JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Willemijn de Klaver, Pieter H. A. Wisse, Francine van Wifferen, Linda J. W. Bosch, Connie R. Jimenez, Rene W. M. van der Hulst, Remond J. A. Fijneman, Ernst J. Kuipers, Marjolein J. E. Greuter, Beatriz Carvalho, Manon C. W. Spaander, Evelien Dekker, Veerle M. H. Coupe, Meike de Wit, Gerrit A. Meijer
Summary: In this study, the multitarget FIT (mtFIT) showed improved diagnostic accuracy in detecting advanced neoplasia compared to FIT, particularly in detecting advanced adenomas. Early health technology assessment indicated that mtFIT-based screening could be cost-effective.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Oncology
Yasuyuki Okada, Fuduan Peng, Jose Perea, Luis Corchete, Luis Bujanda, Wei Li, Ajay Goel
Summary: A novel methylation signature risk-scoring model was developed to reliably identify patients with synchronous colorectal cancer (SyCRC), which has the potential to improve the diagnosis and management of colorectal cancer (CRC) patients.
BRITISH JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Antonio Giordano, Gherzon Casanova, Miriam Escapa, Gloria Fernandez-Esparrach, Angels Gines, Oriol Sendino, Isis K. Araujo, Andres Cardenas, Henry Cordova, Julia Martinez-Ocon, Graciela Martinez-Palli, Francesc Balaguer, Josep Llach, Elena Ricart, Begona Gonzalez-Suarez
Summary: Motorized Spiral Enteroscopy (MSE) is an effective and safe examination method for patients with prior major abdominal surgery. Although longer procedure times were observed in these patients, the diagnostic yield was similar. Patients with gastrointestinal surgery showed a lower depth of insertion compared to those with other abdominal surgeries.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Genetics & Heredity
Yasmin Soares de Lima, Coral Arnau-Collell, Jenifer Munoz, Cristina Herrera-Pariente, Leticia Moreira, Teresa Ocana, Marcos Diaz-Gay, Sebastia Franch-Exposito, Miriam Cuatrecasas, Sabela Carballal, Anael Lopez-Novo, Lorena Moreno, Guerau Fernandez, Aranzazu Diaz de Bustamante, Sophia Peters, Anna K. Sommer, Isabel Spier, Iris B. A. W. te Paske, Yasmijn J. van Herwaarden, Antoni Castells, Luis Bujanda, Gabriel Capella, Verena Steinke-Lange, Khalid Mahmood, JiHoon Eric Joo, Julie Arnold, Susan Parry, Finlay A. Macrae, Ingrid M. Winship, Christophe Rosty, Joaquin Cubiella, Daniel Rodriguez-Alcalde, Elke Holinski-Feder, Richarda de Voer, Daniel D. Buchanan, Stefan Aretz, Clara Ruiz-Ponte, Laura Valle, Francesc Balaguer, Laia Bonjoch, Sergi Castellvi-Bel
Summary: Rare germline variants in the WNK2 gene were identified through functional evaluation of a candidate gene and replication in additional SPS cohorts. These variants may affect protein function in the MAPK pathway, thereby increasing the risk for SPS.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Geriatrics & Gerontology
Marta Del Pozo-Valero, Marta Corton, Rosario Lopez-Rodriguez, Ignacio Mahillo-Fernandez, Javier Ruiz-Hornillos, Pablo Minguez, Cristina Villaverde, Maria Elena Perez-Tomas, Maria Barreda-Sanchez, Esther Mancebo, Estela Paz-Artal, Encarna Guillen-Navarro, Berta Almoguera, Carmen Ayuso
Summary: This study reveals the association between clonal hematopoiesis and mortality in COVID-19 patients, particularly showing a significant correlation between pathogenic/likely pathogenic clonal hematopoiesis and mortality in the 75-84 age group.
Article
Gastroenterology & Hepatology
Francisco J. Caballero-Camino, Pedro M. Rodrigues, Fredrik Wangsell, Alona Agirre-Lizaso, Paula Olaizola, Laura Izquierdo-Sanchez, Maria J. Perugorria, Luis Bujanda, Bo Angelin, Sara Straniero, Anna Walleback, Ingemar Starke, Per-Goran Gillberg, Ellen Strangberg, Britta Bonn, Jan P. Mattsson, Martin R. Madsen, Henrik H. Hansen, Erik Lindstrom, Peter Akerblad, Jesus M. Banales
Summary: The ASBT inhibitor A3907 improves cholestatic liver diseases by clearing circulating bile acids and protecting liver function. A3907 targets ASBT in the intestine, liver, and kidney, leading to improved bilirubin and liver injury markers. A3907 is well tolerated in healthy individuals, supporting further clinical development.
Article
Medicine, General & Internal
Enrique Bernal, Eva Garcia-Villalba, Eduardo Pons, Maria Dolores Hernandez, Carlos Baguena, Gabriel Puche, Paula Carter, Monica Martinez, Antonia Alcaraz, Cristina Tomas, Angeles Munoz, Maria Rosario Vicente, Maria Luz Nunez, Natalia Sancho, Mari Carmen Villalba, Alfredo Cano, Alfredo Minguela
Summary: This study compared the clinical outcomes of COVID-19 hospitalized patients treated with remdesivir plus dexamethasone versus dexamethasone alone, according to their vaccination status. The results showed that patients treated with remdesivir plus dexamethasone had reduced need for intensive care, high-flow oxygen, and non-invasive mechanical ventilation, as well as fewer complications during hospitalization. Treatment with remdesivir plus dexamethasone and vaccination were independent factors associated with lower progression to mechanical ventilation or death.
Article
Gastroenterology & Hepatology
Joel Flores-Arriaga, Maria C. Aso, Arantzazu Izagirre, Ami D. Sperber, Olafur S. Palsson, Shrikant I. Bangdiwala, Angel Lanas, Luis Bujanda, Beatriz Lobo, Carmen Alonso-Cotoner, Alex Sanchez-Pla, Javier Santos
Summary: The study used data from the Rome Foundation Global Epidemiology Study to assess the prevalence and burden of gut-brain disorders in Spain. The survey, completed by 2072 participants, revealed that 43.6% of respondents met diagnostic criteria for at least one disorder, with functional constipation being the most prevalent. The study highlights the need for specialized training and future research in this area.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Engineering, Environmental
Katri Rankinen, Virpi Junttila, Martyn Futter, Jose Enrique Cano Bernal, Daniel Butterfield, Maria Holmberg
Summary: The browning of surface waters due to increased terrestrial loading of dissolved organic carbon is a global phenomenon. This study focused on understanding the impact of environmental changes on the brownification of Kukkia lake in Finland. By using process-based models and hindcasting scenarios, the researchers found that changes in forest cuttings were the primary cause for the brownification.
Article
Health Care Sciences & Services
Marjan Meurisse, Francisco Estupinan-Romero, Javier Gonzalez-Galindo, Natalia Martinez-Lizaga, Santiago Royo-Sierra, Simon Saldner, Lorenz Dolanski-Aghamanoukjan, Alexander Degelsegger-Marquez, Stian Soiland-Reyes, Nina Van Goethem, Enrique Bernal-Delgado
Summary: This article describes a methodological framework for conducting causal inference using federated cross-national sensitive observational data, aiming to fill the current guidance gap and allow rapid response in the case of a next pandemic.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Correction
Medicine, Research & Experimental
M. Masia, S. Padilla, G. Estan, J. Portu, A. Silva, A. Rivero, A. Gonzalez-Cordon, L. Garcia-Fraile, O. Martinez, E. Bernal, C. Galera, V. Boix Martinez, J. Macias, M. Montero, D. Garcia-Rosado, M. J. Vivancos-Gallego, J. Llenas-Garcia, M. Torralba, J. A. Garcia, V. Agullo, M. Fernandez-Gonzalez, F. Gutierrez, E. Martinez
Article
Immunology
Hortensia Alvarez, Alicia Gutierrez-Valencia, Ana Marino, Abraham Saborido-Alconchel, Beatriz Calderon-Cruz, Alexandre Perez-Gonzalez, Jacobo Alonso-Dominguez, Ines Martinez-Barros, Maria Gallego-Rodriguez, Santiago Moreno, Teresa Aldamiz, Marta Montero-Alonso, Enrique Bernal, Carlos Galera, Josep M. Llibre, Eva Poveda, CoRIS Study Grp
Summary: This study assessed the dynamics of IP-10 and MIG levels in HIV-1 patients after initiating antiretroviral treatment (ART). The results showed a significant decline in IP-10 and MIG plasma levels following ART initiation, with greater declines in MIG levels in INSTI-based regimens. These findings suggest that HIV-1 viremia has a strong impact on IP-10 and MIG levels.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Javier Martinez-Sanz, Jorge Diaz-alvarez, Marta Rosas, Raquel Ron, Jose Antonio Iribarren, Enrique Bernal, Felix Gutierrez, Andres Ruiz Sancho, Noemi Cabello, Julian Olalla, Santiago Moreno, Sergio Serrano-Villar
Summary: The study suggests that a low CD4/CD8 ratio during HIV treatment is associated with immunosenescence. Data analysis shows that patients with a CD4/CD8 ratio less than 0.3 in the second year of ART have an increased risk of developing SNAEs in the next five years.
Article
Medicine, General & Internal
Juan Javier Garcia-Fernandez, Jose Andres Sanchez-Nicolas, Sonia Galicia-Puyol, Isabel Gil-Rosa, Juan Jose Guerras-Conesa, Enrique Bernal-Morell, Cesar Cinesi-Gomez
Summary: This study assessed the failure of therapies in patients with hypoxemic acute respiratory failure due to SARS-CoV-2. The results showed that the combined therapy of HFNO and CPAP had a lower failure rate, while Bilevel therapy had the highest failure rate.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Gastroenterology & Hepatology
Maja Thiele, Miquel Serra-Burriel, Isabel Graupera, Aleksander Krag
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Anja Domenghino, Roxane Diane Staiger, Fariba Abbassi, Miquel Serra-Burriel, Kim Leutwyler, Guillaume Aeby, Matthias Turina, Christian Alexander Gutschow, Pierre-Alain Clavien, Milo Alan Puhan
Summary: This study compared patient selection and postoperative outcomes for gastrointestinal surgeries before and during the SARS-CoV-2 pandemic. The results showed a reduction in caseload during certain periods, but no significant decrease in overall procedures. The population characteristics differed, with lower Body Mass Indices and more patients smoking and having diabetes in 2020. Delivering surgical care to COVID-19 patients in the same hospital was found to be safe, and healthcare officials should consider continuing surgical care during future health crises.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)