Sequence-based classification of type II polyketide synthase biosynthetic gene clusters for antiSMASH

The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters

(2018) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

PRISM 3: expanded prediction of natural product chemical structures from microbial genomes

(2017) Michael A. Skinnider et al.   NUCLEIC ACIDS RESEARCH

antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification

(2017) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Cloning and identification of saprolmycin biosynthetic gene cluster fromStreptomycessp. TK08046

(2016) Takashi Kawasaki et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Natural product discovery: past, present, and future

(2016) Leonard Katz et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

The evolution of genome mining in microbes – a review

(2016) Nadine Ziemert et al.   NATURAL PRODUCT REPORTS

IMG-ABC: new features for bacterial secondary metabolism analysis and targeted biosynthetic gene cluster discovery in thousands of microbial genomes

(2016) Michalis Hadjithomas et al.   NUCLEIC ACIDS RESEARCH

The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters

(2016) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Minimum Information about a Biosynthetic Gene cluster

(2015) Marnix H Medema et al.   Nature Chemical Biology

Computational approaches to natural product discovery

(2015) Marnix H Medema et al.   Nature Chemical Biology

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

(2015) Tilmann Weber et al.   NUCLEIC ACIDS RESEARCH

Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM)

(2015) Michael A. Skinnider et al.   NUCLEIC ACIDS RESEARCH

Biosynthesis of trioxacarcin revealing a different starter unit and complex tailoring steps for type II polyketide synthase

(2015) Mei Zhang et al.   Chemical Science

Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens

(2013) Tao Zhu et al.   METABOLIC ENGINEERING

Identification of the chelocardin biosynthetic gene cluster from Amycolatopsis sulphurea: a platform for producing novel tetracycline antibiotics

(2013) T. Lukezic et al.   MICROBIOLOGY-SGM

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

PKMiner: a database for exploring type II polyketide synthases

(2012) Jinki Kim et al.   BMC MICROBIOLOGY

DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters

(2012) Natsuko Ichikawa et al.   NUCLEIC ACIDS RESEARCH

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites

(2011) Z. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accelerated Profile HMM Searches

(2011) Sean R. Eddy   PLoS Computational Biology

Isolation of the lysolipin gene cluster of Streptomyces tendae Tü 4042

(2010) Patricio Lopez et al.   GENE

Oxytetracycline Biosynthesis

(2010) Lauren B. Pickens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclization of aromatic polyketides from bacteria and fungi

(2010) Hui Zhou et al.   NATURAL PRODUCT REPORTS

FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments

(2010) Morgan N. Price et al.   PLoS One

BLAST+: architecture and applications

(2009) Christiam Camacho et al.   BMC BIOINFORMATICS

Decoding and engineering tetracycline biosynthesis

(2008) Lauren B. Pickens et al.   METABOLIC ENGINEERING