Lupus-Associated Immune Complexes Activate Human Neutrophils in an FcγRIIA-Dependent but TLR-Independent Response

TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA

(2017) Christian Lood et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antinuclear antibody testing — misunderstood or misbegotten?

(2017) David S. Pisetsky   Nature Reviews Rheumatology

Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients

(2016) Romain Banchereau et al.   CELL

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Viral evasion of intracellular DNA and RNA sensing

(2016) Ying Kai Chan et al.   NATURE REVIEWS MICROBIOLOGY

A volcanic explosion of autoantibodies in systemic lupus erythematosus: A diversity of 180 different antibodies found in SLE patients

(2015) Gal Yaniv et al.   AUTOIMMUNITY REVIEWS

Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection

(2015) Pengyan Xia et al.   NATURE IMMUNOLOGY

RNA sensing by conventional dendritic cells is central to the development of lupus nephritis

(2015) Teja Celhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of an Immunoregulatory and Antiviral Gene Expression Program in Poly(I:C)-Transfected Human Neutrophils

(2014) N. Tamassia et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Type 4 Cyclic Nucleotide Phosphodiesterase Blocks Intracellular TLR Signaling in Chronic Lymphocytic Leukemia and Normal Hematopoietic Cells

(2014) Ying Tan et al.   JOURNAL OF IMMUNOLOGY

Immobilized Immune Complexes Induce Neutrophil Extracellular Trap Release by Human Neutrophil Granulocytes via FcγRIIIB and Mac-1

(2014) Martina Behnen et al.   JOURNAL OF IMMUNOLOGY

Neutrophils at work

(2014) William M Nauseef et al.   NATURE IMMUNOLOGY

Gene Expression during the Generation and Activation of Mouse Neutrophils: Implication of Novel Functional and Regulatory Pathways

(2014) Jeffrey A. Ericson et al.   PLoS One

Cytoplasmic receptors recognizing nucleic acids and mediating immune functions in neutrophils

(2013) Nicola Tamassia et al.   CURRENT OPINION IN PHARMACOLOGY

Guanine Modification of Inhibitory Oligonucleotides Potentiates Their Suppressive Function

(2013) F. Rommler et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Endocytosis of soluble immune complexes leads to their clearance by Fc RIIIB but induces neutrophil extracellular traps via Fc RIIA in vivo

(2012) K. Chen et al.   BLOOD

Neutrophils Express Distinct RNA Receptors in a Non-canonical Way

(2012) Michael Berger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

B Cell TLR7 Expression Drives Anti-RNA Autoantibody Production and Exacerbates Disease in Systemic Lupus Erythematosus-Prone Mice

(2012) S.-H. Hwang et al.   JOURNAL OF IMMUNOLOGY

Taming lupus—a new understanding of pathogenesis is leading to clinical advances

(2012) Zheng Liu et al.   NATURE MEDICINE

Protein kinase C, an elusive therapeutic target?

(2012) Daria Mochly-Rosen et al.   NATURE REVIEWS DRUG DISCOVERY

The role of TLRs in neutrophil activation

(2011) Lynne R Prince et al.   CURRENT OPINION IN PHARMACOLOGY

Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

(2011) A. Kuznik et al.   JOURNAL OF IMMUNOLOGY

The role of antimalarial agents in the treatment of SLE and lupus nephritis

(2011) Senq-J Lee et al.   Nature Reviews Nephrology

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs

(2010) M. F. Denny et al.   JOURNAL OF IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Platelet CD154 Potentiates Interferon-  Secretion by Plasmacytoid Dendritic Cells in Systemic Lupus Erythematosus

(2010) P. Duffau et al.   Science Translational Medicine

Requirement for DNA CpG Content in TLR9-Dependent Dendritic Cell Activation Induced by DNA-Containing Immune Complexes

(2009) K. Yasuda et al.   JOURNAL OF IMMUNOLOGY

DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Faslpr/lpr mice in vivo

(2009) Petar Lenert et al.   ARTHRITIS RESEARCH & THERAPY

Neutrophil recognition of bacterial DNA and Toll-like receptor 9-dependent and -independent regulation of neutrophil function

(2008) Driss El Kebir et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Systemic Lupus Erythematosus

(2008) Anisur Rahman et al.   NEW ENGLAND JOURNAL OF MEDICINE

ETosis: A Novel Cell Death Pathway

(2008) F. Wartha et al.   Science Signaling