siRNA Lipid–Polymer Nanoparticles Targeting E-Selectin and Cyclophilin A in Bone Marrow for Combination Multiple Myeloma Therapy

Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma

(2023) Marta Larrayoz et al.   NATURE MEDICINE

In vivo bone marrow microenvironment siRNA delivery using lipid–polymer nanoparticles for multiple myeloma therapy

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Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy

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Targeting E-selectin to Tackle Cancer Using Uproleselan

(2021) Barbara Muz et al.   Cancers

Bone Marrow Stromal Cells-Induced Drug Resistance in Multiple Myeloma

(2020) Roberto Ria et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

(2020) Margaret M. Billingsley et al.   NANO LETTERS

Multiple Myeloma: Available Therapies and Causes of Drug Resistance

(2020) Vanessa Pinto et al.   Cancers

Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche

(2020) Marvin Krohn-Grimberghe et al.   Nature Biomedical Engineering

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Delivery technologies for cancer immunotherapy

(2019) Rachel S. Riley et al.   NATURE REVIEWS DRUG DISCOVERY

Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening

(2019) Pedro P.G. Guimaraes et al.   JOURNAL OF CONTROLLED RELEASE

Evaluating the Mechanisms of Light-Triggered siRNA Release from Nanoshells for Temporal Control Over Gene Regulation

(2018) Rachel S. Riley et al.   NANO LETTERS

Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA

(2018) Rebecca L. Ball et al.   NANO LETTERS

Drug resistance in multiple myeloma

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Nanoparticles That Deliver RNA to Bone Marrow Identified by in Vivo Directed Evolution

(2018) Cory D. Sago et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing

(2018) Cory D. Sago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E-selectin ligands recognised by HECA452 induce drug resistance in myeloma, which is overcome by the E-selectin antagonist, GMI-1271

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Multiple myeloma

(2017) Shaji K. Kumar et al.   Nature Reviews Disease Primers

Progress and Paradigms in Multiple Myeloma

(2016) Kenneth C. Anderson   CLINICAL CANCER RESEARCH

Multiple myeloma and persistence of drug resistance in the age of novel drugs (Review)

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Structure, activity and uptake mechanism of siRNA-lipid nanoparticles with an asymmetric ionizable lipid

(2016) Yuta Suzuki et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Molecular basis of resistance to proteasome inhibitors in hematological malignancies

(2015) Denise Niewerth et al.   DRUG RESISTANCE UPDATES

Cell adhesion down-regulates the expression of vacuolar protein sorting 4B (VPS4B) and contributes to drug resistance in multiple myeloma cells

(2015) Jie Tang et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

The Cyclophilin A–CD147 complex promotes the proliferation and homing of multiple myeloma cells

(2015) Di Zhu et al.   NATURE MEDICINE

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

(2014) James E. Dahlman et al.   Nature Nanotechnology

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Cyclophilin A: a key player for human disease

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Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation

(2012) Delai Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance

(2012) Ingrid G Winkler et al.   NATURE MEDICINE

Multiple Myeloma

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Multiple myeloma: biology of the disease

(2010) Anuj Mahindra et al.   BLOOD REVIEWS

Knocking down barriers: advances in siRNA delivery

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