Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer

The long tail of oncogenic drivers in prostate cancer

(2018) Joshua Armenia et al.   NATURE GENETICS

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets

(2018) David C. Wedge et al.   NATURE GENETICS

Regulatory protein SrpA controls phage infection and core cellular processes in Pseudomonas aeruginosa

(2018) Jiajia You et al.   Nature Communications

Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis

(2017) Huairui Yuan et al.   JOURNAL OF CLINICAL INVESTIGATION

AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis

(2017) Ni Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer

(2017) Di Zhao et al.   NATURE

Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

(2017) Xiangpeng Dai et al.   NATURE MEDICINE

Synthetic lethality and cancer

(2017) Nigel J. O'Neil et al.   NATURE REVIEWS GENETICS

Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response

(2017) Jia Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic plasticity and the hallmarks of cancer

(2017) William A. Flavahan et al.   SCIENCE

NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture

(2017) Maria B. Olsen et al.   Cell Reports

Targeting EZH2 in cancer

(2016) Kimberly H Kim et al.   NATURE MEDICINE

Organoid culture systems for prostate epithelial and cancer tissue

(2016) Jarno Drost et al.   Nature Protocols

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

(2016) Andrew P. Feinberg et al.   NATURE REVIEWS GENETICS

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

Decreased TSPAN1 promotes prostate cancer progression and is a marker for early biochemical recurrence after radical prostatectomy

(2016) Fan Xu et al.   Oncotarget

A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon

(2016) Dong Gao et al.   PLoS One

Integrative Clinical Genomics of Advanced Prostate Cancer

(2015) Dan Robinson et al.   CELL

Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation

(2015) Nilotpal Roy et al.   GENES & DEVELOPMENT

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

(2015) Kimberly H Kim et al.   NATURE MEDICINE

Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers

(2015) Benjamin G Bitler et al.   NATURE MEDICINE

Vulnerabilities of Mutant SWI/SNF Complexes in Cancer

(2014) Katherine C. Helming et al.   CANCER CELL

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

(2014) Dong Gao et al.   CELL

Androgen deprivation–induced NCoA2 promotes metastatic and castration-resistant prostate cancer

(2014) Jun Qin et al.   JOURNAL OF CLINICAL INVESTIGATION

The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma

(2014) Guido von Figura et al.   NATURE CELL BIOLOGY

Recurrent SMARCA4 mutations in small cell carcinoma of the ovary

(2014) Petar Jelinic et al.   NATURE GENETICS

ARID1B is a specific vulnerability in ARID1A-mutant cancers

(2014) Katherine C Helming et al.   NATURE MEDICINE

Brg1 Loss Attenuates Aberrant Wnt-Signalling and Prevents Wnt-Dependent Tumourigenesis in the Murine Small Intestine

(2014) Aliaksei Z. Holik et al.   PLoS Genetics

Pten Loss and RAS/MAPK Activation Cooperate to Promote EMT and Metastasis Initiated from Prostate Cancer Stem/Progenitor Cells

(2012) D. J. Mulholland et al.   CANCER RESEARCH

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis

(2012) Jun Qin et al.   NATURE

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer Patients

(2011) T. L. Lotan et al.   CLINICAL CANCER RESEARCH

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

(2011) Zhihu Ding et al.   NATURE

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

Bmi-1 Is a Crucial Regulator of Prostate Stem Cell Self-Renewal and Malignant Transformation

(2010) Rita U. Lukacs et al.   Cell Stem Cell

Molecular genetics of prostate cancer: new prospects for old challenges

(2010) M. M. Shen et al.   GENES & DEVELOPMENT

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CEAS: cis-regulatory element annotation system

(2009) Hyunjin Shin et al.   BIOINFORMATICS

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

(2009) Daming Gao et al.   NATURE CELL BIOLOGY

Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis

(2009) Jennifer C King et al.   NATURE GENETICS

Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

(2009) Brett S Carver et al.   NATURE GENETICS

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE