Article
Oncology
Xiang-jun Chen, Sha Liu, Dong-mei Han, De-zhi Han, Wei-jing Sun, Xiao-chun Zhao, Jun-qing Liang, Li Yu
Summary: Melanoma is a major skin malignancy with unclear molecular drivers for progression and prognosis. FUT8-AS1 has been identified as a lncRNA related to melanoma prognosis, and its downregulation is associated with aggressive clinical factors. Functionally, FUT8-AS1 suppresses melanoma cell proliferation, migration, and invasion by regulating the NF90/miR-145-5p/NRAS/MAPK signaling axis, highlighting its potential as a therapeutic target for melanoma treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Lei Wang, Ying Tan, Ziyu Zhu, Jun Chen, Qiang Sun, Zhibin Ai, Chunqi Ai, Yu Xing, Guohou He, Yong Liu
Summary: The study demonstrates that ATP2B1-AS1 is upregulated in cerebral ischemia/reperfusion injury, and regulates cell survival, apoptosis, and inflammation through miR-330-5p and TLR4. Additionally, ATP2B1-AS1 affects neurological function in rats and their performance in the Morris water maze test.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiuchen Guo, Jingbo Zhang, Jingya Zeng, Yiwei Guo, Lina Zhao
Summary: The study demonstrates that miR-525-5p inhibits the progression of DLBCL through the Myd88/NF-kappa B pathway.
Article
Cell Biology
Yuan Luo, Qi Yao
Summary: This study found that circRNA_0085315 plays an important role in colon cancer. It acts as a ceRNA to activate the MAPK signaling pathway through the miR-1200/MAP3K1 axis, promoting the progression of colon cancer.
Article
Pharmacology & Pharmacy
Yangyang Xia, Shouzhen Chen, Jianfeng Cui, Yong Wang, Xiaochen Liu, Yangli Shen, Li Gong, Xuewen Jiang, Wenfu Wang, Yaofeng Zhu, Shuna Sun, Jiangxia Li, Yongxin Zou, Benkang Shi
Summary: Hyperactivation of STAT3 is closely related to cancer progression, and BBR has been shown to have anti-tumor effects on BCa cells by inhibiting JAK1-STAT3 signaling through upregulation of miR-17-5p, which may serve as a potential therapeutic option for BCa treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Zhi Li, Zejin Wang, Shaobo Yang, Chong Shen, Yinglang Zhang, Runxue Jiang, Zhe Zhang, Yu Zhang, Hailong Hu
Summary: This study identified a novel circRNA called circSTK39, which was downregulated in bladder cancer tissues and cell lines and associated with worse prognosis. Mechanistically, circSTK39 inhibited the epithelial-mesenchymal transition (EMT) processes of bladder cancer cells by acting as a sponge for miR-135a-5p and inhibiting NR3C2.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiang-jun Chen, Sha Liu, Dong-mei Han, De-zhi Han, Wei-jing Sun, Xiao-chun Zhao
Summary: RP11-705C15.3 is identified as an oncogene in melanoma, which promotes tumor growth and metastasis by regulating the miR-145-5p/NRAS/MAPK signaling axis, and is positively correlated with the malignancy and overall survival of melanoma patients.
CANCER GENE THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Haiyan Zeng, Lei Li, Yi Gao, Guojun Wu, Zhouhua Hou, Shuiping Liu
Summary: The study suggests that UCA1, as a long noncoding RNA, plays a role in HCV infection by competitively inhibiting the expression of miR-145-5p, increasing the level of SOCS7, and subsequently suppressing interferon response and HCV replication.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Rucheng Yan, Weiwei Dai, Ruixin Wu, Houbao Huang, Minfeng Shu
Summary: Abnormal RNA methylation and dysregulation of miRNA are common in bladder cancer, and melittin has shown potential as a drug candidate for intravesical chemotherapy against bladder cancer. METTL3 has been identified as a key regulator in controlling bladder cancer cells' sensitivity to melittin-induced apoptosis, while miR-146a-5p suppression contributes to the selective antitumor effect of melittin.
Article
Cell Biology
Tian Xia, Zhiyong Zhang, Xin Zhang, Quanfu Li
Summary: This study aimed to determine the effect of the interaction between miR-186-3p and KRT18 on the biological behavior of colon cancer cells. The results showed that miR-186-3p suppresses proliferation and viability, but facilitates apoptosis in colon cancer cells by targeting KRT18 and negatively regulating the MAPK signaling pathway.
Article
Biochemistry & Molecular Biology
Liangliang Ren, Minxiao Jiang, Dingwei Xue, Huan Wang, Zeyi Lu, Lifeng Ding, Haiyun Xie, Ruyue Wang, Wenqin Luo, Li Xu, Mingchao Wang, Shicheng Yu, Sheng Cheng, Liqun Xia, Haifeng Yu, Peng Huang, Naijin Xu, Gonghui Li
Summary: The study reveals that nitroxoline suppresses metastasis in bladder cancer via the EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Yu Liu, Haitao Yu, Bin Zeng, Xin Gou, Ke Ren, Fangchao Yuan
Summary: miR-383-5p functions as a tumor-suppressing gene by inhibiting the PI3K/AKT signaling pathway, thereby preventing the development of bladder cancer. Reduced expression of miR-383-5p has been observed in bladder cancer tissue and cell lines, and up-regulation of miR-383-5p inhibits proliferation and migration while enhancing apoptosis in bladder cancer cells.
Article
Cell Biology
Yi Zhu, Ling Zuo, Hong Xiong, Shihao Li, Ruiqi Chen, Hongwei Liu
Summary: In this study, circHGS was found to be upregulated in bladder cancer and positively associated with tumor grade and pathological T stage. Silencing of circHGS inhibited cell cycle, proliferation, migration and invasion, while its overexpression had the opposite effect. Mechanistically, circHGS acted as a sponge of miR-513a-5p to increase VEGFC expression and activate the AKT/mTOR pathway, ultimately promoting bladder cancer progression. These findings suggest that circHGS may serve as a promising therapeutic target for bladder cancer.
Article
Biotechnology & Applied Microbiology
Yidong Cheng, Hao Yu, Kai Li, Jiancheng Lv, Juntao Zhuang, Kexin Bai, Qikai Wu, Xiao Yang, Haiwei Yang, Qiang Lu
Summary: Accumulating evidence has shown that hsa_circ_0003098 plays a vital role in bladder cancer (BCa). The overexpression of hsa_circ_0003098 is associated with poor prognosis and promotes BCa cell proliferation, migration, invasion, and tumor growth. Mechanistically, hsa_circ_0003098 acts as a sponge for miR-377-5p, promoting the upregulation of ACAT2 expression and inducing cholesteryl ester accumulation. Therefore, hsa_circ_0003098 could serve as a potential biomarker and therapeutic target for BCa.
Article
Oncology
Yi Du, Xudong Zhang, Hongwei Zhang, Yiding Chen, Shuying Zhu, Jinjun Shu, Hui Pan
Summary: Propofol has been found to significantly suppress the proliferation, migration, and invasion of bladder cancer cells in vitro, largely through the upregulation of miR-145-5p expression. Silencing the direct target of miR-145-5p, TOP2A, reversed the effects of propofol treatment in bladder cancer cells. Additionally, propofol was shown to suppress tumor xenograft growth, with partial attenuation by miR-145-5p knockdown.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)