Traditional Chinese medicine as targeted treatment for epithelial‐mesenchymal transition‐induced cancer progression

Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial–mesenchymal transition and stemness

(2018) Jingjing Wang et al.   CANCER LETTERS

The clinical and biological roles of transforming growth factor beta in colon cancer stem cells: A systematic review

(2018) Anna Chruścik et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Overexpression of ELF3 facilitates cell growth and metastasis through PI3K/Akt and ERK signaling pathways in non-small cell lung cancer

(2018) Hao Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Matrine inhibiting pancreatic cells epithelial-mesenchymal transition and invasion through ROS/NF-κB/MMPs pathway

(2018) Minna Huang et al.   LIFE SCIENCES

Yiqi Huayu Jiedu Decoction Inhibits the Invasion and Metastasis of Gastric Cancer Cells through TGF-β/Smad Pathway

(2017) Ting-Ting Wu et al.   Evidence-based Complementary and Alternative Medicine

Zonula occludens-1/NF-κB/CXCL8: a new regulatory axis for tumor angiogenesis

(2017) Julien Lesage et al.   FASEB JOURNAL

The Expression and Functional Significance of Runx2 in Hepatocellular Carcinoma: Its Role in Vasculogenic Mimicry and Epithelial–Mesenchymal Transition

(2017) Zi Cao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical Cancer Advances 2017: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology

(2017) Harold J. Burstein et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer stem cells in colorectal cancer: a review

(2017) Matthew J Munro et al.   JOURNAL OF CLINICAL PATHOLOGY

Numb prevents a complete epithelial–mesenchymal transition by modulating Notch signalling

(2017) Federico Bocci et al.   Journal of the Royal Society Interface

Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways

(2017) Jingkun Zhao et al.   Molecular Cancer

FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer

(2017) Shucai Yang et al.   Molecular Cancer

Traditional Chinese medicine, Fuzheng Kang-Ai decoction, inhibits metastasis of lung cancer cells through the STAT3/MMP9 pathway

(2017) Longmei Li et al.   Molecular Medicine Reports

EMT: Present and future in clinical oncology

(2017) Patricia G. Santamaria et al.   Molecular Oncology

EMT and inflammation: inseparable actors of cancer progression

(2017) Meggy Suarez-Carmona et al.   Molecular Oncology

New insights into the role of EMT in tumor immune escape

(2017) Stéphane Terry et al.   Molecular Oncology

Thymoquinone Inhibits the Migration and Invasive Characteristics of Cervical Cancer Cells SiHa and CaSki In Vitro by Targeting Epithelial to Mesenchymal Transition Associated Transcription Factors Twist1 and Zeb1

(2017) Jun Li et al.   MOLECULES

Ginsenoside Rb1 inhibits hypoxia-induced epithelial-mesenchymal transition in ovarian cancer cells by regulating microRNA-25

(2017) Dan Liu et al.   Experimental and Therapeutic Medicine

Curcumin downregulates the expression of Snail via suppressing Smad2 pathway to inhibit TGF-β1-induced epithelial-mesenchymal transitions in hepatoma cells

(2017) Meng-Ting Cao et al.   Oncotarget

SYNJ2BP promotes the degradation of PTEN through the lysosome-pathway and enhances breast tumor metastasis via PI3K/AKT/SNAI1 signaling

(2017) Miao Wang et al.   Oncotarget

Common cytotoxic chemotherapeutics induce epithelial-mesenchymal transition (EMT) downstream of ER stress

(2017) Parag P. Shah et al.   Oncotarget

Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity

(2017) Stéphane Terry et al.   OncoImmunology

Long Non-Coding RNAs: Key Regulators of Epithelial-Mesenchymal Transition, Tumour Drug Resistance and Cancer Stem Cells

(2017) Richard Heery et al.   Cancers

Complex Determinants of Epithelial: Mesenchymal Phenotypic Plasticity in Ovarian Cancer

(2017) Yuliya Klymenko et al.   Cancers

Interleukin-17 induces human alveolar epithelial to mesenchymal cell transition via the TGF-β1 mediated Smad2/3 and ERK1/2 activation

(2017) Ting Wang et al.   PLoS One

Glucocorticoids ameliorate TGF-β1-mediated epithelial-to-mesenchymal transition of airway epithelium through MAPK and Snail/Slug signaling pathways

(2017) Hyun-Woo Yang et al.   Scientific Reports

Carnosol controls the human glioblastoma stemness features through the epithelial-mesenchymal transition modulation and the induction of cancer stem cell apoptosis

(2017) Chiara Giacomelli et al.   Scientific Reports

Yi Ai Fang, a traditional Chinese herbal formula, impacts the vasculogenic mimicry formation of human colorectal cancer through HIF-1α and epithelial mesenchymal transition

(2016) Fenggang Hou et al.   BMC Complementary and Alternative Medicine

TGF-β signaling in liver and gastrointestinal cancers

(2016) L.H. Katz et al.   CANCER LETTERS

High Infiltration of Tumor-Associated Macrophages Influences Poor Prognosis in Human Gastric Cancer Patients, Associates With the Phenomenon of EMT

(2016) Jia Zhang et al.   MEDICINE

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

High tumor-associated macrophages infiltration is associated with poor prognosis and may contribute to the phenomenon of epithelial–mesenchymal transition in gastric cancer

(2016) Jian-sheng Wang et al.   OncoTargets and Therapy

IL-8 signaling is involved in resistance of lung carcinoma cells to erlotinib

(2016) Romaine I. Fernando et al.   Oncotarget

Notch1 promotes vasculogenic mimicry in hepatocellular carcinoma by inducing EMT signaling

(2016) Chen Jue et al.   Oncotarget

Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells

(2016) James A. McCubrey et al.   Oncotarget

Pharmacoproteomic analysis reveals that metapristone (RU486 metabolite) intervenes E-cadherin and vimentin to realize cancer metastasis chemoprevention

(2016) Suhong Yu et al.   Scientific Reports

Hypoxia-induced vasculogenic mimicry formation in human colorectal cancer cells: Involvement of HIF-1a, Claudin-4, and E-cadherin and Vimentin

(2016) Wen Li et al.   Scientific Reports

Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression

(2016) Limo Chen et al.   OncoImmunology

Analysis of the TGFβ-induced program in primary airway epithelial cells shows essential role of NF-κB/RelA signaling network in type II epithelial mesenchymal transition

(2015) Bing Tian et al.   BMC GENOMICS

CXCR2/CXCL5 axis contributes to epithelial–mesenchymal transition of HCC cells through activating PI3K/Akt/GSK-3β/Snail signaling

(2015) Shao-Lai Zhou et al.   CANCER LETTERS

The Epithelial-Mesenchymal Transition and Cancer Stem Cells: Functional and Mechanistic Links

(2015) Xiangqiang Liu et al.   CURRENT PHARMACEUTICAL DESIGN

Cancer stem cell: Fundamental experimental pathological concepts and updates

(2015) Farhadul Islam et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8–Akt–Slug pathway

(2015) C Visciano et al.   ONCOGENE

Jagged–Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype

(2015) Marcelo Boareto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomarkers and signaling pathways of colorectal cancer stem cells

(2015) Danysh Abetov et al.   TUMOR BIOLOGY

Interleukin-23 promotes the epithelial-mesenchymal transition of oesophageal carcinoma cells via the Wnt/β-catenin pathway

(2015) Deyu Chen et al.   Scientific Reports

A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis

(2014) Shicheng Su et al.   CANCER CELL

CCL20 and CXCL8 synergize to promote progression and poor survival outcome in patients with colorectal cancer by collaborative induction of the epithelial–mesenchymal transition

(2014) Xian-Shuo Cheng et al.   CANCER LETTERS

Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathway

(2014) XIU-TAO FU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

TWIST1 and SNAI1 as markers of poor prognosis in human colorectal cancer are associated with the expression of ALDH1 and TGF-β1

(2014) YONG HUN KIM et al.   ONCOLOGY REPORTS

Curcumin Suppresses Crosstalk between Colon Cancer Stem Cells and Stromal Fibroblasts in the Tumor Microenvironment: Potential Role of EMT

(2014) Constanze Buhrmann et al.   PLoS One

The emerging role of Twist proteins in hematopoietic cells and hematological malignancies

(2014) N Merindol et al.   Blood Cancer Journal

Systems biology approaches to understanding Epithelial Mesenchymal Transition (EMT) in mucosal remodeling and signaling in asthma

(2014) Talha Ijaz et al.   World Allergy Organization Journal

Cyclin-dependent kinase 4 signaling acts as a molecular switch between syngenic differentiation and neural transdifferentiation in human mesenchymal stem cells

(2013) Janet Lee et al.   CELL CYCLE

Mechanisms that link the oncogenic epithelial–mesenchymal transition to suppression of anoikis

(2013) Steven M. Frisch et al.   JOURNAL OF CELL SCIENCE

Inhibition of TGF- 1 Signaling Promotes Central Memory T Cell Differentiation

(2013) S. Takai et al.   JOURNAL OF IMMUNOLOGY

Epithelial-Mesenchymal Transition Induced by TNF-  Requires NF- B-Mediated Transcriptional Upregulation of Twist1

(2012) C.-W. Li et al.   CANCER RESEARCH

Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells

(2012) W.-B. Tsai et al.   CANCER RESEARCH

Pten Loss and RAS/MAPK Activation Cooperate to Promote EMT and Metastasis Initiated from Prostate Cancer Stem/Progenitor Cells

(2012) D. J. Mulholland et al.   CANCER RESEARCH

TGF-β signaling and epithelial–mesenchymal transition in cancer progression

(2012) Yoko Katsuno et al.   CURRENT OPINION IN ONCOLOGY

Epithelial to mesenchymal transition and cancer stem cell phenotypes leading to liver metastasis are abrogated by the novel TGFβ1-targeting peptides P17 and P144

(2012) Idoia G. Zubeldia et al.   EXPERIMENTAL CELL RESEARCH

Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colon

(2012) Ferenc Sipos   WORLD JOURNAL OF GASTROENTEROLOGY

MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGF R2) in colon cancer cells

(2011) Y. Yu et al.   CARCINOGENESIS

SNAIL Regulates Interleukin-8 Expression, Stem Cell–Like Activity, and Tumorigenicity of Human Colorectal Carcinoma Cells

(2011) Wei–Lun Hwang et al.   GASTROENTEROLOGY

IL-6 Promotes Head and Neck Tumor Metastasis by Inducing Epithelial-Mesenchymal Transition via the JAK-STAT3-SNAIL Signaling Pathway

(2011) A. Yadav et al.   MOLECULAR CANCER RESEARCH

Mesenchymal Transition and Dissemination of Cancer Cells Is Driven by Myeloid-Derived Suppressor Cells Infiltrating the Primary Tumor

(2011) Benjamin Toh et al.   PLOS BIOLOGY

Targeting Notch signaling pathway to overcome drug resistance for cancer therapy

(2010) Zhiwei Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Antiestrogens Induce Transforming Growth Factor  -Mediated Immunosuppression in Breast Cancer

(2010) C. M. Joffroy et al.   CANCER RESEARCH

Targeting Notch to Target Cancer Stem Cells

(2010) A. Pannuti et al.   CLINICAL CANCER RESEARCH

Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression

(2010) Douglas S. Micalizzi et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Notch signaling specifies prosensory domains via lateral induction in the developing mammalian inner ear

(2010) B. H. Hartman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular networks for the study of TCM Pharmacology

(2009) J. Zhao et al.   BRIEFINGS IN BIOINFORMATICS

Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway

(2009) Z. Wang et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

The Epithelial-to-Mesenchymal Transition and Cancer Stem Cells: A Coalition Against Cancer Therapies

(2009) Brett G. Hollier et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells

(2009) N J Sullivan et al.   ONCOGENE

Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways

(2008) T. T. Onder et al.   CANCER RESEARCH

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

(2008) Kyle Niessen et al.   JOURNAL OF CELL BIOLOGY

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA