An interaction network between the SNARE VAMP7 and Rab GTPases within a ciliary membrane-targeting complex

BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone

(2018) Fan Ye et al.   JOURNAL OF CELL BIOLOGY

The Arf GEF GBF1 and Arf4 synergize with the sensory receptor cargo, rhodopsin, to regulate ciliary membrane trafficking

(2017) Jing Wang et al.   JOURNAL OF CELL SCIENCE

Loss-of-function of the ciliopathy protein Cc2d2a disorganizes the vesicle fusion machinery at the periciliary membrane and indirectly affects Rab8-trafficking in zebrafish photoreceptors

(2017) Irene Ojeda Naharros et al.   PLoS Genetics

The primary cilium as a cellular receiver: organizing ciliary GPCR signaling

(2016) Keren I Hilgendorf et al.   CURRENT OPINION IN CELL BIOLOGY

A Presenilin-2–ARF4 trafficking axis modulates Notch signaling during epidermal differentiation

(2016) Ellen J. Ezratty et al.   JOURNAL OF CELL BIOLOGY

BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers

(2016) Megan K. Dennis et al.   JOURNAL OF CELL BIOLOGY

Rabin8 regulates neurite outgrowth in both GEF activity–dependent and –independent manners

(2016) Yuta Homma et al.   MOLECULAR BIOLOGY OF THE CELL

Structural and molecular bases of rod photoreceptor morphogenesis and disease

(2016) Theodore G. Wensel et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Molecular basis for photoreceptor outer segment architecture

(2016) Andrew F.X. Goldberg et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Multiple Roles of VARP in Endosomal Trafficking: Rabs, Retromer Components and R-SNARE VAMP7 Meet on VARP

(2016) Mitsunori Fukuda   TRAFFIC

VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8

(2016) Debapriya Ghosh et al.   Nature Communications

Phosphatidylinositol-3-phosphate is light-regulated and essential for survival in retinal rods

(2016) Feng He et al.   Scientific Reports

Ins and outs of GPCR signaling in primary cilia

(2015) K. B. Schou et al.   EMBO REPORTS

Preparation of Xenopus laevis retinal cryosections for electron microscopy

(2015) Beatrice M. Tam et al.   EXPERIMENTAL EYE RESEARCH

Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3

(2015) Georg F. Vogel et al.   JOURNAL OF CELL BIOLOGY

Discs of mammalian rod photoreceptors form through the membrane evagination mechanism

(2015) Jin-Dong Ding et al.   JOURNAL OF CELL BIOLOGY

The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting

(2015) J. Wang et al.   JOURNAL OF CELL SCIENCE

Structure and function of longin SNAREs

(2015) F. Daste et al.   JOURNAL OF CELL SCIENCE

Mechanistic insights into the recycling machine of the SNARE complex

(2015) Minglei Zhao et al.   NATURE

Structure of Rab11–FIP3–Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11

(2015) Melanie Vetter et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment

(2015) Thomas Burgoyne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional organization of nascent rod outer segment disk membranes

(2015) Stefanie Volland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet–Biedl syndrome

(2015) Poppy Datta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spring-loaded unraveling of a single SNARE complex by NSF in one round of ATP turnover

(2015) J.-K. Ryu et al.   SCIENCE

Structure of Rab11–FIP3–Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11

(2015) Melanie Vetter et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Principle of Membrane Fusion in the Cell (Nobel Lecture)

(2014) James Edward Rothman   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

VAMP7 Modulates Ciliary Biogenesis in Kidney Cells

(2014) Christina M. Szalinski et al.   PLoS One

Increased activity of the Vesicular SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor TI-VAMP/VAMP7 by Tyrosine Phosphorylation in the Longin Domain

(2013) Andrea Burgo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary cilia in neurodevelopmental disorders

(2013) Enza Maria Valente et al.   Nature Reviews Neurology

Protein sorting, targeting and trafficking in photoreceptor cells

(2013) Jillian N. Pearring et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Molecular complexes that direct rhodopsin transport to primary cilia

(2013) Jing Wang et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Longin and GAF Domains: Structural Evolution and Adaptation to the Subcellular Trafficking Machinery

(2013) Nicola De Franceschi et al.   TRAFFIC

Structural Basis of the Intracellular Sorting of the SNARE VAMP7 by the AP3 Adaptor Complex

(2012) Helen M. Kent et al.   DEVELOPMENTAL CELL

A Molecular Network for the Transport of the TI-VAMP/VAMP7 Vesicles from Cell Center to Periphery

(2012) Andrea Burgo et al.   DEVELOPMENTAL CELL

The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting

(2012) Jing Wang et al.   EMBO JOURNAL

A Rab8 Guanine Nucleotide Exchange Factor-Effector Interaction Network Regulates Primary Ciliogenesis

(2012) Shanshan Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The pollen-specific R-SNARE/longin PiVAMP726 mediates fusion of endo- and exocytic compartments in pollen tube tip growth

(2012) F. Guo et al.   JOURNAL OF EXPERIMENTAL BOTANY

Absence of TI-VAMP/Vamp7 Leads to Increased Anxiety in Mice

(2012) L. Danglot et al.   JOURNAL OF NEUROSCIENCE

The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation

(2012) Ingmar B Schäfer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Autophagosome Precursor Maturation Requires Homotypic Fusion

(2011) Kevin Moreau et al.   CELL

Ciliary diffusion barrier: The gatekeeper for the primary cilium compartment

(2011) Qicong Hu et al.   Cytoskeleton

The ciliopathy gene cc2d2a controls zebrafish photoreceptor outer segment development through a role in Rab8-dependent vesicle trafficking

(2011) Ruxandra Bachmann-Gagescu et al.   HUMAN MOLECULAR GENETICS

Photoreceptor Signaling: Supporting Vision across a Wide Range of Light Intensities

(2011) Vadim Y. Arshavsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemistry and Biology of Vision

(2011) Krzysztof Palczewski   JOURNAL OF BIOLOGICAL CHEMISTRY

A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1

(2011) Heather H. Ward et al.   MOLECULAR BIOLOGY OF THE CELL

Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

(2011) C. J. Westlake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Longin SNARE VAMP7/TI-VAMP Adopts a Closed Conformation

(2010) Sandro Vivona et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of TI-VAMP and CD82 in EGFR cell-surface dynamics and signaling

(2010) L. Danglot et al.   JOURNAL OF CELL SCIENCE

Functional genomic screen for modulators of ciliogenesis and cilium length

(2010) Joon Kim et al.   NATURE

Coordination of Rab8 and Rab11 in primary ciliogenesis

(2010) A. Knodler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Vertebrate Primary Cilium in Development, Homeostasis, and Disease

(2009) Jantje M. Gerdes et al.   CELL

Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4

(2009) Jana Mazelova et al.   EMBO JOURNAL

Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth

(2009) Andrea Burgo et al.   EMBO REPORTS

Multiple roles of the vesicular-SNARE TI-VAMP in post-Golgi and endosomal trafficking

(2009) Mathilde Chaineau et al.   FEBS LETTERS

Syntaxin 3 and SNAP-25 pairing, regulated by omega-3 docosahexaenoic acid, controls the delivery of rhodopsin for the biogenesis of cilia-derived sensory organelles, the rod outer segments

(2009) J. Mazelova et al.   JOURNAL OF CELL SCIENCE

Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes

(2009) Takeshi Ohya et al.   NATURE

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Basis for the Sorting of the SNARE VAMP7 into Endocytic Clathrin-Coated Vesicles by the ArfGAP Hrb

(2008) Paul R. Pryor et al.   CELL

Depletion of apical transport proteins perturbs epithelial cyst formation and ciliogenesis

(2008) J. M. Torkko et al.   JOURNAL OF CELL SCIENCE

Arf GTPase-activating Protein ASAP1 Interacts with Rab11 Effector FIP3 and Regulates Pericentrosomal Localization of Transferrin Receptor–positive Recycling Endosome

(2008) Hiroki Inoue et al.   MOLECULAR BIOLOGY OF THE CELL

elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8

(2008) Yoshihiro Omori et al.   NATURE CELL BIOLOGY