High frequency of H3 K27M mutations in adult midline gliomas

A suggestion to introduce the diagnosis of “diffuse midline glioma of the pons, H3 K27 wildtype (WHO grade IV)”

(2018) André O. von Bueren et al.   ACTA NEUROPATHOLOGICA

cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutant

(2018) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Adult Brainstem Gliomas With H3K27M Mutation: Radiology, Pathology, and Prognosis

(2018) Elena V Daoud et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

DNA methylation-based classification of central nervous system tumours

(2018) David Capper et al.   NATURE

Pediatric ganglioglioma with an H3 K27M mutation arising from the cervical spinal cord

(2018) Tomohiro Okuda et al.   NEUROPATHOLOGY

Brainstem pilocytic astrocytoma with H3 K27M mutation: case report

(2017) Shuhei Morita et al.   JOURNAL OF NEUROSURGERY

Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location

(2017) Michael Karremann et al.   NEURO-ONCOLOGY

Characteristics of H3 K27M-mutant gliomas in adults

(2017) David Meyronet et al.   NEURO-ONCOLOGY

Low FoxG1 and high Olig-2 labelling indices define a prognostically favourable subset in isocitrate dehydrogenase (IDH)-mutant gliomas

(2017) S. Schäfer et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

K27M mutation inH3F3Ain ganglioglioma grade I with spontaneous malignant transformation extends the histopathological spectrum of the histone H3 oncogenic pathway

(2017) N. Joyon et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Absence of MGMT promoter methylation in diffuse midline glioma, H3 K27M-mutant

(2017) Rouzbeh Banan et al.   Acta Neuropathologica Communications

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

(2016) Scott A. Foster et al.   CANCER CELL

Validation of the high-performance of pyrosequencing for clinical MGMT testing on a cohort of glioblastoma patients from a prospective dedicated multicentric trial

(2016) Véronique Quillien et al.   Oncotarget

Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics

(2016) Lindsey M. Hoffman et al.   Acta Neuropathologica Communications

Targeted detection of genetic alterations reveal the prognostic impact of H3K27M and MAPK pathway aberrations in paediatric thalamic glioma

(2016) Scott Ryall et al.   Acta Neuropathologica Communications

ATRX immunostaining predicts IDH and H3F3A status in gliomas

(2016) Azadeh Ebrahimi et al.   Acta Neuropathologica Communications

Pilocytic astrocytoma and glioneuronal tumor with histone H3 K27M mutation

(2016) Cordelia Orillac et al.   Acta Neuropathologica Communications

Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers

(2015) Andrey Korshunov et al.   ACTA NEUROPATHOLOGICA

Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes

(2015) David Castel et al.   ACTA NEUROPATHOLOGICA

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets

(2015) Felix Sahm et al.   ACTA NEUROPATHOLOGICA

Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity

(2015) Andrey Korshunov et al.   ACTA NEUROPATHOLOGICA

Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations

(2015) David A. Solomon et al.   BRAIN PATHOLOGY

The H3.3 K27M mutation results in a poorer prognosis in brainstem gliomas than thalamic gliomas in adults

(2015) Jie Feng et al.   HUMAN PATHOLOGY

Adult brainstem gliomas: Correlation of clinical and molecular features

(2015) Brett J. Theeler et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Histopathological spectrum of paediatric diffuse intrinsic pontine glioma: diagnostic and therapeutic implications

(2014) Pawel Buczkowicz et al.   ACTA NEUROPATHOLOGICA

A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas

(2014) Sriram Venneti et al.   ACTA NEUROPATHOLOGICA

Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas

(2014) Denise Bechet et al.   ACTA NEUROPATHOLOGICA

Diffuse intrinsic pontine glioma: a reassessment

(2014) Nathan J. Robison et al.   JOURNAL OF NEURO-ONCOLOGY

The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

(2014) Gang Wu et al.   NATURE GENETICS

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

(2014) Pawel Buczkowicz et al.   NATURE GENETICS

Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

(2014) Kathryn R Taylor et al.   NATURE GENETICS

Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma

(2014) Adam M Fontebasso et al.   NATURE GENETICS

Predicting the likelihood of an isocitrate dehydrogenase 1 or 2 mutation in diagnoses of infiltrative glioma

(2014) L. Chen et al.   NEURO-ONCOLOGY

Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children

(2013) Tene A. Cage et al.   CHILDS NERVOUS SYSTEM

Molecular analysis of diffuse intrinsic brainstem gliomas in adults

(2013) German Reyes-Botero et al.   JOURNAL OF NEURO-ONCOLOGY

A multi-disciplinary consensus statement concerning surgical approaches to low-grade, high-grade astrocytomas and diffuse intrinsic pontine gliomas in childhood (CPN Paris 2011) using the Delphi method

(2013) D. A. Walker et al.   NEURO-ONCOLOGY

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

Diffuse intrinsic pontine tumors: a study of primitive neuroectodermal tumors versus the more common diffuse intrinsic pontine gliomas

(2012) Alexandra Sufit et al.   Journal of Neurosurgery-Pediatrics

Mesenchymal Transition and PDGFRA Amplification/Mutation Are Key Distinct Oncogenic Events in Pediatric Diffuse Intrinsic Pontine Gliomas

(2012) Stephanie Puget et al.   PLoS One

Confirmation of R132H mutation of isocitrate dehydrogenase 1 as an independent prognostic factor in anaplastic astrocytoma

(2011) Jens Schittenhelm et al.   ACTA NEUROPATHOLOGICA

Genome-Wide Analyses Identify Recurrent Amplifications of Receptor Tyrosine Kinases and Cell-Cycle Regulatory Genes in Diffuse Intrinsic Pontine Glioma

(2011) Barbara S. Paugh et al.   JOURNAL OF CLINICAL ONCOLOGY

Brainstem gliomas in children and adults

(2008) Florence Laigle-Donadey et al.   CURRENT OPINION IN ONCOLOGY