Lys-63-linked Ubiquitination by E3 Ubiquitin Ligase Nedd4-1 Facilitates Endosomal Sequestration of Internalized α-Synuclein

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease

(2014) Sian E. Davies et al.   NEUROBIOLOGY OF DISEASE

Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein–coupled receptor kinase–dependent manner

(2013) Susumu Hara et al.   MOLECULAR BIOLOGY OF THE CELL

Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis

(2013) David Freeman et al.   PLoS One

Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates  -Synuclein Toxicity in Neurons

(2013) D. F. Tardiff et al.   SCIENCE

Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation

(2012) Igor F. Tsigelny et al.   FEBS Journal

Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

(2012) Masatoshi Konno et al.   Molecular Neurodegeneration

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Localization of CHMP2B-immunoreactivity in the brainstem of Lewy body disease

(2012) Takashi Kurashige et al.   NEUROPATHOLOGY

Endosomal sorting related protein CHMP2B is localized in Lewy bodies and glial cytoplasmic inclusions in α-synucleinopathy

(2012) Satoshi Tanikawa et al.   NEUROSCIENCE LETTERS

Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking

(2011) Amy Lin et al.   JOURNAL OF NEUROCHEMISTRY

The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of α-Synuclein

(2011) Takafumi Hasegawa et al.   PLoS One

Ubiquitin ligase Nedd4 promotes  -synuclein degradation by the endosomal-lysosomal pathway

(2011) G. K. Tofaris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the β2-adrenergic receptor

(2010) Joseph F Nabhan et al.   EMBO REPORTS

Calcium Activates Nedd4 E3 Ubiquitin Ligases by Releasing the C2 Domain-mediated Auto-inhibition

(2010) Jian Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Lipid-binding Domain of Wild Type and Mutant α-Synuclein

(2010) Elka R. Georgieva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

(2010) Jobin Varkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aggregation of α-Synuclein in S. cerevisiae is Associated with Defects in Endosomal Trafficking and Phospholipid Biosynthesis

(2010) James H. Soper et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Are synucleinopathies prion-like disorders?

(2010) Elodie Angot et al.   LANCET NEUROLOGY

Cell-to-cell transmission of non-prion protein aggregates

(2010) Seung-Jae Lee et al.   Nature Reviews Neurology

The ubiquitin code of yeast permease trafficking

(2010) Elsa Lauwers et al.   TRENDS IN CELL BIOLOGY

K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway

(2009) Elsa Lauwers et al.   JOURNAL OF CELL BIOLOGY

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

(2009) Pei-Hsien Ren et al.   NATURE CELL BIOLOGY

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assembly-dependent endocytosis and clearance of extracellular a-synuclein

(2008) He-Jin Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Serine 129 Phosphorylation of α-Synuclein Induces Unfolded Protein Response-mediated Cell Death

(2008) Naoto Sugeno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHIP Targets Toxic α-Synuclein Oligomers for Degradation

(2008) Julie E. Tetzlaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY