Differential Effects of Posttranslational Modifications of CXCL8/Interleukin-8 on CXCR1 and CXCR2 Internalization and Signaling Properties

How post-translational modifications influence the biological activity of chemokines

(2018) Vincent Vanheule et al.   CYTOKINE

Glycosaminoglycans Regulate CXCR3 Ligands at Distinct Levels: Protection against Processing by Dipeptidyl Peptidase IV/CD26 and Interference with Receptor Signaling

(2017) Mieke Metzemaekers et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of Regulation of the Chemokine-Receptor Network

(2017) Martin Stone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CCL2 nitration is a negative regulator of chemokine-mediated inflammation

(2017) Catriona E. Barker et al.   Scientific Reports

Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo

(2016) Rik Janssens et al.   Oncotarget

Regulation of Chemokine Activity – A Focus on the Role of Dipeptidyl Peptidase IV/CD26

(2016) Mieke Metzemaekers et al.   Frontiers in Immunology

Heparan Sulphate as a Regulator of Leukocyte Recruitment in Inflammation

(2015) Archana Kumar et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Biased Signaling at Chemokine Receptors

(2015) Jenny Corbisier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging Functional Divergence of β-Arrestin Isoforms in GPCR Function

(2015) Ashish Srivastava et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

CXCL8 – The First Chemokine

(2015) Marco Baggiolini   Frontiers in Immunology

The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases

(2014) Remo C Russo et al.   Expert Review of Clinical Immunology

Neutrophils at work

(2014) William M Nauseef et al.   NATURE IMMUNOLOGY

Biased and G Protein-Independent Signaling of Chemokine Receptors

(2014) Anne Steen et al.   Frontiers in Immunology

In vivo regulation of chemokine activity by post-translational modification

(2013) Eva AV Moelants et al.   IMMUNOLOGY AND CELL BIOLOGY

Signalling bias in new drug discovery: detection, quantification and therapeutic impact

(2013) Terry Kenakin et al.   NATURE REVIEWS DRUG DISCOVERY

Measurements of ligand bias and functional affinity

(2013) Terry Kenakin et al.   NATURE REVIEWS DRUG DISCOVERY

Inflammatory Chemokines Direct and Restrict Leukocyte Migration within Live Tissues as Glycan-Bound Gradients

(2012) Milka Sarris et al.   CURRENT BIOLOGY

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

Overview of the mechanisms regulating chemokine activity and availability

(2012) Anneleen Mortier et al.   IMMUNOLOGY LETTERS

Endogenous Ligand Bias by Chemokines: Implications at the Front Lines of Infection and Leukocyte Trafficking

(2012) David A. Zidar   Endocrine Metabolic & Immune Disorders-Drug Targets

A Simple Method for Quantifying Functional Selectivity and Agonist Bias

(2011) Terry Kenakin et al.   ACS Chemical Neuroscience

Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells

(2011) Barbara Molon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biological Activity of CXCL8 Forms Generated by Alternative Cleavage of the Signal Peptide or by Aminopeptidase-Mediated Truncation

(2011) Anneleen Mortier et al.   PLoS One

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

(2010) S. Massena et al.   BLOOD

Effect of posttranslational processing on the in vitro and in vivo activity of chemokines

(2010) Anneleen Mortier et al.   EXPERIMENTAL CELL RESEARCH

Endothelial Heparan Sulfate Controls Chemokine Presentation in Recruitment of Lymphocytes and Dendritic Cells to Lymph Nodes

(2010) Xingfeng Bao et al.   IMMUNITY

Characterization of the Chemokine CXCL11-Heparin Interaction Suggests Two Different Affinities for Glycosaminoglycans

(2010) India C. Severin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Posttranslational Modification of the NH2-terminal Region of CXCL5 by Proteases or Peptidylarginine Deiminases (PAD) Differently Affects Its Biological Activity

(2010) Anneleen Mortier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Arrestins Scaffold Cofilin with Chronophin to Direct Localized Actin Filament Severing and Membrane Protrusions Downstream of Protease-activated Receptor-2

(2010) Maria Zoudilova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive and chemokine-dependent internalization and recycling of CXCR7 in breast cancer cells to degrade chemokine ligands

(2010) K E Luker et al.   ONCOGENE

Chemokine receptors intracellular trafficking

(2010) Elena M. Borroni et al.   PHARMACOLOGY & THERAPEUTICS

 -Arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation

(2009) R. Molteni et al.   BLOOD

Chemokines and chemokine receptors: an overview

(2009) Raffaella Bonecchi   Frontiers in Bioscience-Landmark

Citrullination of CXCL8 increases this chemokine's ability to mobilize neutrophils into the blood circulation

(2009) T. Loos et al.   HAEMATOLOGICA

Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation

(2008) Paul Proost et al.   JOURNAL OF EXPERIMENTAL MEDICINE

How chemokines invite leukocytes to dance

(2008) Marcus Thelen et al.   NATURE IMMUNOLOGY