AMP-Activated Protein Kinase as a Key Trigger for the Disuse-Induced Skeletal Muscle Remodeling

Early endplate remodeling and skeletal muscle signaling events following rat hindlimb suspension

(2018) Alexander V. Chibalin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of interleukin-6 decreases atrogene expression and ameliorates tail suspension-induced skeletal muscle atrophy

(2018) Mitsutaka Yakabe et al.   PLoS One

AMPK Mediates Muscle Mass Change But Not the Transition of Myosin Heavy Chain Isoforms during Unloading and Reloading of Skeletal Muscles in Mice

(2018) Tatsuro Egawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sarcolemmal loss of active nNOS (Nos1) is an oxidative stress-dependent, early event driving disuse atrophy

(2018) Anna Lechado i Terradas et al.   JOURNAL OF PATHOLOGY

Posters

(2017)   FEBS Journal

Rapid decline in MyHC I(β) mRNA expression in rat soleus during hindlimb unloading is associated with AMPK dephosphorylation

(2017) Natalia A. Vilchinskaya et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exercise-mediated modulation of autophagy in skeletal muscle

(2017) M. Martin-Rincon et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Morphological Regeneration and Functional Recovery of Neuromuscular Junctions after Tourniquet-Induced Injuries in Mouse Hindlimb

(2017) Huiyin Tu et al.   Frontiers in Physiology

AMP-activated kinase α2 deficiency protects mice from denervation-induced skeletal muscle atrophy

(2016) Yuting Guo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

PGC-1α over-expression suppresses the skeletal muscle atrophy and myofiber-type composition during hindlimb unloading

(2016) Jing Wang et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Effects of hindlimb unloading on neurotrophins in the rat spinal cord and soleus muscle

(2016) Wei Yang et al.   BRAIN RESEARCH

Key Markers of mTORC1-Dependent and mTORC1-Independent Signaling Pathways Regulating Protein Synthesis in Rat Soleus Muscle During Early Stages of Hindlimb Unloading

(2016) Timur Mirzoev et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Characterization of neuromuscular synapse function abnormalities in multiple Duchenne muscular dystrophy mouse models

(2016) Elizabeth M. van der Pijl et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Myriocin prevents muscle ceramide accumulation but not muscle fiber atrophy during short-term mechanical unloading

(2016) Erwann Salaun et al.   JOURNAL OF APPLIED PHYSIOLOGY

PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells

(2016) Kimberly A. Coughlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct α2 Na,K-ATPase membrane pools are differently involved in early skeletal muscle remodeling during disuse

(2016) Violetta V. Kravtsova et al.   JOURNAL OF GENERAL PHYSIOLOGY

Immobilization induces nuclear accumulation of HDAC4 in rat skeletal muscle

(2016) Toshinori Yoshihara et al.   Journal of Physiological Sciences

Age-related Differences in Dystrophin: Impact on Force Transfer Proteins, Membrane Integrity, and Neuromuscular Junction Stability

(2016) David C. Hughes et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Specialized Functional Diversity and Interactions of the Na,K-ATPase

(2016) Vladimir V. Matchkov et al.   Frontiers in Physiology

Age-related fragmentation of the motor endplate is not associated with impaired neuromuscular transmission in the mouse diaphragm

(2016) Silvia Willadt et al.   Scientific Reports

Involvement of AMPK in regulating slow-twitch muscle atrophy during hindlimb unloading in mice

(2015) Tatsuro Egawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

General and specific lipid–protein interactions in Na,K-ATPase

(2015) F. Cornelius et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Role of Cholesterol in the Maintenance of Endplate Electrogenesis in Rat Diaphragm

(2015) V. V. Kravtsova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Reduced expression of MyHC slow isoform in rat soleus during unloading is accompanied by alterations of endogenous inhibitors of calcineurin/NFAT signaling pathway

(2015) Yulia N. Lomonosova et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

HDAC4 Regulates Muscle Fiber Type-Specific Gene Expression Programs

(2015) Todd J. Cohen et al.   MOLECULES AND CELLS

Chronic Treatment with the AMPK Agonist AICAR Prevents Skeletal Muscle Pathology but Fails to Improve Clinical Outcome in a Mouse Model of Severe Spinal Muscular Atrophy

(2015) Clàudia Cerveró et al.   Neurotherapeutics

Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting

(2015) Lionel A. Tintignac et al.   PHYSIOLOGICAL REVIEWS

Dystrophin–glycoprotein complex regulates muscle nitric oxide production through mechanoregulation of AMPK signaling

(2015) Joanne F. Garbincius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expanding roles for AMPK in skeletal muscle plasticity

(2015) Rémi Mounier et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Isoform-Specific Na,K-ATPase Alterations Precede Disuse-Induced Atrophy of Rat Soleus Muscle

(2015) Violetta V. Kravtsova et al.   Biomed Research International

Pre- and postsynaptic changes in the neuromuscular junction in dystrophic mice

(2015) Stephen J. P. Pratt et al.   Frontiers in Physiology

Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation

(2014) D. Lee Hamilton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle

(2014) Chang-Ting Hsieh et al.   CELLULAR SIGNALLING

Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress

(2014) Sean L. McGee et al.   FASEB JOURNAL

Peripheral nerve and neuromuscular junction pathology in Pompe disease

(2014) Darin J. Falk et al.   HUMAN MOLECULAR GENETICS

PGC1-α over-expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice

(2014) Jessica Cannavino et al.   JOURNAL OF PHYSIOLOGY-LONDON

Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

(2014) Silvia Carnio et al.   Cell Reports

Degeneration of Neuromuscular Junction in Age and Dystrophy

(2014) Rüdiger Rudolf et al.   Frontiers in Aging Neuroscience

The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle

(2014) Marta Gonzalez-Freire et al.   Frontiers in Aging Neuroscience

Altered content of AMP-activated protein kinase isoforms in skeletal muscle from spinal cord injured subjects

(2013) Emil Kostovski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors

(2013) Muzamil Majid Khan et al.   Autophagy

The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis

(2013) Elaine A. Dunlop et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Disuse-induced muscle wasting

(2013) Sue C. Bodine   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Effect of Muscle Unloading, Reloading and Exercise on Inflammation during a Head-down Bed Rest

(2013) M. Mutin-Carnino et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

Neutral Phospholipids Stimulate Na,K-ATPase Activity

(2013) Haim Haviv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism

(2013) Zhenji Gan et al.   JOURNAL OF CLINICAL INVESTIGATION

ROLE of exercise in maintaining the integrity of the neuromuscular junction

(2013) Hiroshi Nishimune et al.   MUSCLE & NERVE

Sequence of Age-Associated Changes to the Mouse Neuromuscular Junction and the Protective Effects of Voluntary Exercise

(2013) Anson Cheng et al.   PLoS One

AMP-activated protein kinase at the nexus of therapeutic skeletal muscle plasticity in Duchenne muscular dystrophy

(2013) Vladimir Ljubicic et al.   TRENDS IN MOLECULAR MEDICINE

Alterations in muscle mass and contractile phenotype in response to unloading models: role of transcriptional/pretranslational mechanisms

(2013) Kenneth M. Baldwin et al.   Frontiers in Physiology

AMPK Activation Stimulates Autophagy and Ameliorates Muscular Dystrophy in the mdx Mouse Diaphragm

(2012) Marion Pauly et al.   AMERICAN JOURNAL OF PATHOLOGY

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

(2012) D. Grahame Hardie et al.   CHEMISTRY & BIOLOGY

AMPK Enhances Insulin-Stimulated GLUT4 Regulation via Lowering Membrane Cholesterol

(2012) Kirk M. Habegger et al.   ENDOCRINOLOGY

Activation of AMP-activated Protein Kinase Stimulates Na+,K+-ATPase Activity in Skeletal Muscle Cells

(2012) Boubacar Benziane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Various Jobs of Proteolytic Enzymes in Skeletal Muscle during Unloading: Facts and Speculations

(2012) E. V. Kachaeva et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Chronic Nicotine Modifies Skeletal Muscle Na,K-ATPase Activity through Its Interaction with the Nicotinic Acetylcholine Receptor and Phospholemman

(2012) Alexander V. Chibalin et al.   PLoS One

AICAR inhibits ceramide biosynthesis in skeletal muscle

(2012) Katherine A Erickson et al.   Diabetology & Metabolic Syndrome

Cross-Talk between AMPK and mTOR in Regulating Energy Balance

(2011) Jia Xu et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Protein kinase D: coupling extracellular stimuli to the regulation of cell physiology

(2011) Ya Fu et al.   EMBO REPORTS

Effect of branched-chain amino acid supplementation during unloading on regulatory components of protein synthesis in atrophied soleus muscles

(2011) Gustavo Bajotto et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Stabilization of the α2 Isoform of Na,K-ATPase by Mutations in a Phospholipid Binding Pocket

(2011) Einat Kapri-Pardes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of α1 Na/K-ATPase Expression by Cholesterol

(2011) Yiliang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Na,K-ATPase Activity in Mouse Muscle is Regulated by AMPK and PGC-1α

(2011) Maria S. Ingwersen et al.   JOURNAL OF MEMBRANE BIOLOGY

Endplate contributions to the safety factor for neuromuscular transmission

(2011) Robert L. Ruff   MUSCLE & NERVE

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Electrostimulation during hindlimb unloading modulates PI3K-AKT downstream targets without preventing soleus atrophy and restores slow phenotype through ERK

(2010) Erwan Dupont et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

AMPK-mediated regulation of transcription in skeletal muscle

(2010) Sean L. McGee et al.   CLINICAL SCIENCE

Time course of ribosomal kinase activity during hindlimb unloading

(2010) E. A. Lysenko et al.   Doklady Biochemistry and Biophysics

Long-term dry immersion: review and prospects

(2010) Nastassia M. Navasiolava et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Differential muscle-driven synaptic remodeling in the neuromuscular junction after denervation

(2010) Pessah Yampolsky et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

AMPK β subunits display isoform specific affinities for carbohydrates

(2010) Ann Koay et al.   FEBS LETTERS

The Nicotinic Acetylcholine Receptor and the Na,K-ATPase α2 Isoform Interact to Regulate Membrane Electrogenesis in Skeletal Muscle

(2010) Judith A. Heiny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitric oxide and AMPK cooperatively regulate PGC-1α in skeletal muscle cells

(2010) Vitor A. Lira et al.   JOURNAL OF PHYSIOLOGY-LONDON

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading

(2009) Clay E. Pandorf et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Stress and Signaling Responses of Rat Skeletal Muscle to Brief Endurance Exercise During Hindlimb Unloading: a Catch-Up Process for Atrophied Muscle

(2009) Taesik Gwag et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

(2009) V. B. Matthews et al.   DIABETOLOGIA

Important role for AMPKα1 in limiting skeletal muscle cell hypertrophy

(2009) Rémi Mounier et al.   FASEB JOURNAL

Rapid muscle atrophy response to unloading: pretranslational processes involving MHC and actin

(2009) Julia M. Giger et al.   JOURNAL OF APPLIED PHYSIOLOGY

Exercise in space: human skeletal muscle after 6 months aboard the International Space Station

(2009) Scott Trappe et al.   JOURNAL OF APPLIED PHYSIOLOGY

Molecular events and signalling pathways involved in skeletal muscle disuse-induced atrophy and the impact of countermeasures

(2009) Angèle Chopard et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Calcium-dependent signaling mechanisms and soleus fiber remodeling under gravitational unloading

(2009) Boris S. Shenkman et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Ubiquitin Ligase Cbl-b Is a Negative Regulator for Insulin-Like Growth Factor 1 Signaling during Muscle Atrophy Caused by Unloading

(2009) R. Nakao et al.   MOLECULAR AND CELLULAR BIOLOGY

AMP-activated protein kinase in skeletal muscle: From structure and localization to its role as a master regulator of cellular metabolism

(2008) C. A. Witczak et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Role of Adenosine 5′-Monophosphate-Activated Protein Kinase in Interleukin-6 Release from Isolated Mouse Skeletal Muscle

(2008) Stephan Glund et al.   ENDOCRINOLOGY

Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase α1 following overload in LKB1 knockout mice

(2008) Sean L. McGee et al.   JOURNAL OF PHYSIOLOGY-LONDON

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Embedded cholesterol in the nicotinic acetylcholine receptor

(2008) G. Brannigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA