期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 19, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ijms19113558
关键词
AMPK; HDAC4; 5; p70S6K; MyHC I(); motor endplate remodeling; soleus muscle; mechanical unloading; hindlimb suspension
资金
- Russian Science Foundation (RSF) [18-15-00107]
- Russian Science Foundation [18-15-00107] Funding Source: Russian Science Foundation
Molecular mechanisms that trigger disuse-induced postural muscle atrophy as well as myosin phenotype transformations are poorly studied. This review will summarize the impact of 5 adenosine monophosphate -activated protein kinase (AMPK) activity on mammalian target of rapamycin complex 1 (mTORC1)-signaling, nuclear-cytoplasmic traffic of class IIa histone deacetylases (HDAC), and myosin heavy chain gene expression in mammalian postural muscles (mainly, soleus muscle) under disuse conditions, i.e., withdrawal of weight-bearing from ankle extensors. Based on the current literature and the authors' own experimental data, the present review points out that AMPK plays a key role in the regulation of signaling pathways that determine metabolic, structural, and functional alternations in skeletal muscle fibers under disuse.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据