IL-33 in obesity: where do we go from here?

IL-33 stimulates expression of the GPR84 ( EX33 ) fatty acid receptor gene and of cytokine and chemokine genes in human adipocytes

(2018) Mohamed S. Zaibi et al.   CYTOKINE

IL-33 attenuates mortality by promoting IFN-γ production in sepsis

(2018) Qi Bao et al.   INFLAMMATION RESEARCH

The IL-33/ST2 pathway, inflammation and atherosclerosis: Trigger and target?

(2018) Alberto Aimo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family

(2017) Corinne Cayrol et al.   IMMUNOLOGICAL REVIEWS

IL-33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs

(2017) Chien-Chang Chen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population

(2017) Daniele C. Nascimento et al.   Nature Communications

Perinatal Licensing of Thermogenesis by IL-33 and ST2

(2016) Justin I. Odegaard et al.   CELL

Interleukin-33 acts as a transcriptional repressor and extracellular cytokine in fibroblast-like synoviocytes in patients with rheumatoid arthritis

(2016) Eun-Ju Lee et al.   CYTOKINE

Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain

(2016) Ana C. Zarpelon et al.   FASEB JOURNAL

IL-33-driven ILC2/eosinophil axis in fat is induced by sympathetic tone and suppressed by obesity

(2016) Xiaofeng Ding et al.   JOURNAL OF ENDOCRINOLOGY

Interleukin-33 facilitates neutrophil recruitment and bacterial clearance in S. aureus-caused peritonitis

(2016) Fang Lan et al.   MOLECULAR IMMUNOLOGY

IL-33-Induced Cytokine Secretion and Survival of Mouse Eosinophils Is Promoted by Autocrine GM-CSF

(2016) Ralf Willebrand et al.   PLoS One

Extracellular IL-33 cytokine, but not endogenous nuclear IL-33, regulates protein expression in endothelial cells

(2016) Violette Gautier et al.   Scientific Reports

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis

(2015) Min-Woo Lee et al.   CELL

Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice

(2015) Dmitriy Kolodin et al.   Cell Metabolism

IL-33 activates eosinophils of visceral adipose tissue both directly and via innate lymphoid cells

(2015) Masaaki Hashiguchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

(2015) Ari B. Molofsky et al.   IMMUNITY

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance

(2015) Jonathan M. Han et al.   JOURNAL OF IMMUNOLOGY

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

(2015) Ajithkumar Vasanthakumar et al.   NATURE IMMUNOLOGY

Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation

(2015) Fahima Madouri et al.   Journal of Molecular Cell Biology

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

(2015) E. Suzanne Cohen et al.   Nature Communications

The Protective Role of Interleukin-33 in Myocardial Ischemia and Reperfusion Is Associated with Decreased HMGB1 Expression and Up-Regulation of the P38 MAPK Signaling Pathway

(2015) Ma Ruisong et al.   PLoS One

IL-33 is negatively associated with the BMI and confers a protective lipid/metabolic profile in non-diabetic but not diabetic subjects

(2014) Amal Hasan et al.   BMC IMMUNOLOGY

An IL-1 Cytokine Member, IL-33, Induces Human Basophil Activation via Its ST2 Receptor

(2014) M. Suzukawa et al.   JOURNAL OF IMMUNOLOGY

Involvement of IL-33 in the pathogenesis of rheumatoid arthritis: the effect of etanercept on the serum levels of IL-33

(2014) Yasunori Kageyama et al.   Modern Rheumatology

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

(2014) Jonathan R. Brestoff et al.   NATURE

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The IL-33/ST2 Pathway Controls Coxsackievirus B5-Induced Experimental Pancreatitis

(2013) R. Sesti-Costa et al.   JOURNAL OF IMMUNOLOGY

Spinal interleukin-33 and its receptor ST2 contribute to bone cancer-induced pain in mice

(2013) J. Zhao et al.   NEUROSCIENCE

Correction: Transcriptome Analysis of Medicinal Plant Salvia miltiorrhiza and Identification of Genes Related to Tanshinone Biosynthesis

(2013) Lei Yang et al.   PLoS One

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

(2013) Irina G. Shabalina et al.   Cell Reports

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue

(2012) M Zeyda et al.   INTERNATIONAL JOURNAL OF OBESITY

Endogenous IL-33 Is Highly Expressed in Mouse Epithelial Barrier Tissues, Lymphoid Organs, Brain, Embryos, and Inflamed Tissues: In Situ Analysis Using a Novel Il-33-LacZ Gene Trap Reporter Strain

(2012) M. Pichery et al.   JOURNAL OF IMMUNOLOGY

IL-33 Priming Regulates Multiple Steps of the Neutrophil-Mediated Anti-Candida albicans Response by Modulating TLR and Dectin-1 Signals

(2012) H. T. Le et al.   JOURNAL OF IMMUNOLOGY

A Perspective on Mammalian Caspases as Positive and Negative Regulators of Inflammation

(2012) Seamus J. Martin et al.   MOLECULAR CELL

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

(2012) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Alarmin Interleukin-33 Drives Protective Antiviral CD8+ T Cell Responses

(2012) W. V. Bonilla et al.   SCIENCE

The Dual Function Cytokine IL-33 Interacts with the Transcription Factor NF- B To Dampen NF- B-Stimulated Gene Transcription

(2011) S. Ali et al.   JOURNAL OF IMMUNOLOGY

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Primary sources and immunological prerequisites for sST2 secretion in humans

(2010) M. Mildner et al.   CARDIOVASCULAR RESEARCH

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

The enigmatic processing and secretion of interleukin-33

(2010) Weihua Zhao et al.   Cellular & Molecular Immunology

Interleukin-33 Induces Protective Effects in Adipose Tissue Inflammation During Obesity in Mice

(2010) Ashley M. Miller et al.   CIRCULATION RESEARCH

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection

(2010) Jose C Alves-Filho et al.   NATURE MEDICINE

Systemically dispersed innate IL-13-expressing cells in type 2 immunity

(2010) A. E. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes

(2009) I. Stuart Wood et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Caspase 3 inactivates biologically active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocation

(2009) Shafaqat Ali et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-γ production

(2009) Elvire Bourgeois et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

(2009) Alexander U. Lüthi et al.   IMMUNITY

Interleukin-33 Is Biologically Active Independently of Caspase-1 Cleavage

(2009) Dominique Talabot-Ayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis

(2009) Naim Alkhouri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages

(2009) T. Ohno et al.   JOURNAL OF IMMUNOLOGY

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

The cytokine interleukin-33 mediates anaphylactic shock

(2009) P. N. Pushparaj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

(2009) C. Cayrol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK Cells

(2008) M. D. Smithgall et al.   INTERNATIONAL IMMUNOLOGY

IL-33 reduces the development of atherosclerosis

(2008) Ashley M. Miller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

(2008) Christine Moussion et al.   PLoS One