Integrative genomic analysis predicts novel functional enhancer-SNPs for bone mineral density

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

(2018) Carolina Medina-Gomez et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Comprehensive Analysis of Non-Synonymous Natural Variants of G Protein-Coupled Receptors

(2018) Hee Ryung Kim et al.   Biomolecules & Therapeutics

Bone loss in women with BRCA1 and BRCA2 mutations

(2018) C. Bethan Powell et al.   GYNECOLOGIC ONCOLOGY

Assessing the Associations of Blood Metabolites With Osteoporosis: A Mendelian Randomization Study

(2018) Li Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

circRNA disease: a manually curated database of experimentally supported circRNA-disease associations

(2018) Zheng Zhao et al.   Cell Death & Disease

Meta-Analysis of Genome-Wide Association Studies Identifies Novel Functional CpG-SNPs Associated with Bone Mineral Density at Lumbar Spine

(2018) Chuan Qiu et al.   International Journal of Genomics

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

(2017) John P Kemp et al.   NATURE GENETICS

Analysis of the mechanism by which nerve growth factor promotes callus formation in mice with tibial fracture

(2017) Xi-Guang Sang et al.   Experimental and Therapeutic Medicine

De Novo Synonymous Mutations in Regulatory Elements Contribute to the Genetic Etiology of Autism and Schizophrenia

(2016) Atsushi Takata et al.   NEURON

3DSNP: a database for linking human noncoding SNPs to their three-dimensional interacting genes

(2016) Yiming Lu et al.   NUCLEIC ACIDS RESEARCH

Enhancer Sequence Variants and Transcription-Factor Deregulation Synergize to Construct Pathogenic Regulatory Circuits in B-Cell Lymphoma

(2015) Olivia I. Koues et al.   IMMUNITY

Identification ofIDUAandWNT16Phosphorylation-Related Non-Synonymous Polymorphisms for Bone Mineral Density in Meta-Analyses of Genome-Wide Association Studies

(2015) Tianhua Niu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture

(2015) Hou‐Feng Zheng et al.   NATURE

The selection and function of cell type-specific enhancers

(2015) Sven Heinz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Paternally Inherited IGF2 Mutation and Growth Restriction

(2015) Matthias Begemann et al.   NEW ENGLAND JOURNAL OF MEDICINE

dbSUPER: a database of super-enhancers in mouse and human genome

(2015) Aziz Khan et al.   NUCLEIC ACIDS RESEARCH

Circulating monocytes: an appropriate model for bone-related study

(2015) Y. Zhou et al.   OSTEOPOROSIS INTERNATIONAL

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

(2015) Harmen H. M. Draisma et al.   Nature Communications

SNiPA: an interactive, genetic variant-centered annotation browser

(2014) Matthias Arnold et al.   BIOINFORMATICS

The Recent Prevalence of Osteoporosis and Low Bone Mass in the United States Based on Bone Mineral Density at the Femoral Neck or Lumbar Spine

(2014) Nicole C Wright et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibitory Immunoglobulin-Like Receptors LILRB and PIR-B Negatively Regulate Osteoclast Development

(2014) Y. Mori et al.   JOURNAL OF IMMUNOLOGY

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2

(2014) Vaibhav Bhatia et al.   NATURE

An atlas of genetic influences on human blood metabolites

(2014) So-Youn Shin et al.   NATURE GENETICS

MiR-125a TNF receptor-associated factor 6 to inhibit osteoclastogenesis

(2013) Li-Juan Guo et al.   EXPERIMENTAL CELL RESEARCH

Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits

(2013) O. Corradin et al.   GENOME RESEARCH

Multistage genome-wide association meta-analyses identified two new loci for bone mineral density

(2013) Lei Zhang et al.   HUMAN MOLECULAR GENETICS

Split-hand/foot malformation - molecular cause and implications in genetic counseling

(2013) Anna Sowińska-Seidler et al.   JOURNAL OF APPLIED GENETICS

The role of estrogen and androgen receptors in bone health and disease

(2013) Stavros C. Manolagas et al.   Nature Reviews Endocrinology

Comprehensive Characterization of Human Genome Variation by High Coverage Whole-Genome Sequencing of Forty Four Caucasians

(2013) Hui Shen et al.   PLoS One

Systematic functional regulatory assessment of disease-associated variants

(2013) Konrad J. Karczewski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing Pluripotency and Lineage Specification

(2013) W. Xie et al.   SCIENCE

Monocytes from patients with osteoarthritis display increased osteoclastogenesis and bone resorption: The In Vitro Osteoclast Differentiation in Arthritis study

(2012) Marianne Durand et al.   ARTHRITIS AND RHEUMATISM

Signaling Networks that Control the Lineage Commitment and Differentiation of Bone Cells

(2012) Carrie S. Soltanoff et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Patient specific proteolytic activity of monocyte-derived macrophages and osteoclasts predicted with temporal kinase activation states during differentiation

(2012) Keon-Young Park et al.   Integrative Biology

Meta-analysis of genome-wide studies identifiesWNT16andESR1SNPs associated with bone mineral density in premenopausal women

(2012) Daniel L Koller et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Systemic Circulation and Bone Recruitment of Osteoclast Precursors Tracked by Using Fluorescent Imaging Techniques

(2012) M. Kotani et al.   JOURNAL OF IMMUNOLOGY

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

(2012) Karol Estrada et al.   NATURE GENETICS

Fast and accurate genotype imputation in genome-wide association studies through pre-phasing

(2012) Bryan Howie et al.   NATURE GENETICS

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

Genetic variation in metabolic phenotypes: study designs and applications

(2012) Karsten Suhre et al.   NATURE REVIEWS GENETICS

Integrative annotation of chromatin elements from ENCODE data

(2012) Michael M. Hoffman et al.   NUCLEIC ACIDS RESEARCH

Inhibition of osteoclast differentiation and matrix metalloproteinase production by CD4+CD25+ T cells in mice

(2012) P. T. Yang et al.   OSTEOPOROSIS INTERNATIONAL

Characterization and Identification of Subpopulations of Mononuclear Preosteoclasts Induced by TNF-α in Combination with TGF-β in Rats

(2012) Rei Matsubara et al.   PLoS One

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Enhancers as information integration hubs in development: lessons from genomics

(2012) Christa Buecker et al.   TRENDS IN GENETICS

Random-Effects Model Aimed at Discovering Associations in Meta-Analysis of Genome-wide Association Studies

(2011) Buhm Han et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Post-genome wide association studies and functional analyses identify association of MPP7 gene variants with site-specific bone mineral density

(2011) Su-Mei Xiao et al.   HUMAN MOLECULAR GENETICS

Genome-wide association of an integrated osteoporosis-related phenotype: Is there evidence for pleiotropic genes?

(2011) David Karasik et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

(2011) L. D. Ward et al.   NUCLEIC ACIDS RESEARCH

SMOC1 Is Essential for Ocular and Limb Development in Humans and Mice

(2010) Ippei Okada et al.   AMERICAN JOURNAL OF HUMAN GENETICS

LocusZoom: regional visualization of genome-wide association scan results

(2010) R. J. Pruim et al.   BIOINFORMATICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Sbds is required for Rac2-mediated monocyte migration and signaling downstream of RANK during osteoclastogenesis

(2010) R. Leung et al.   BLOOD

Genetics of Osteoporosis

(2010) Stuart H. Ralston et al.   ENDOCRINE REVIEWS

MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes

(2010) Yun Li et al.   GENETIC EPIDEMIOLOGY

Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation

(2010) Liang Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Polymorphisms in predicted miRNA binding sites and osteoporosis

(2010) Shu-Feng Lei et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Identification of a gene module associated with BMD through the integration of network analysis and genome-wide association data

(2010) Charles R Farber   JOURNAL OF BONE AND MINERAL RESEARCH

Secretome Analysis of Human BMSCs and Identification of SMOC1 as an Important ECM Protein in Osteoblast Differentiation

(2010) Young-Ae Choi et al.   JOURNAL OF PROTEOME RESEARCH

IGF expression patterns and regulation in growth plate chondrocytes

(2010) Werner Schlegel et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Discovery and characterization of chromatin states for systematic annotation of the human genome

(2010) Jason Ernst et al.   NATURE BIOTECHNOLOGY

Genome-Wide Association Study Identifies ALDH7A1 as a Novel Susceptibility Gene for Osteoporosis

(2010) Yan Guo et al.   PLoS Genetics

Zerumbone Abolishes RANKL-Induced NF-κB Activation, Inhibits Osteoclastogenesis, and Suppresses Human Breast Cancer–Induced Bone Loss in Athymic Nude Mice

(2009) Bokyung Sung et al.   CANCER RESEARCH

The homeobox gene Mohawk represses transcription by recruiting the sin3A/HDAC co-repressor complex

(2009) Douglas M. Anderson et al.   DEVELOPMENTAL DYNAMICS

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

(2009) Fernando Rivadeneira et al.   NATURE GENETICS

Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation

(2009) J. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The proliferative human monocyte subpopulation contains osteoclast precursors

(2009) Roya Lari et al.   ARTHRITIS RESEARCH & THERAPY

SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms

(2008) C. Chelala et al.   BIOINFORMATICS

GOEAST: a web-based software toolkit for Gene Ontology enrichment analysis

(2008) Qi Zheng et al.   NUCLEIC ACIDS RESEARCH