Multi-SKAT: General framework to test for rare-variant association with multiple phenotypes

Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study

(2018) Tanya M Teslovich et al.   HUMAN MOLECULAR GENETICS

Powerful Genetic Association Analysis for Common or Rare Variants with High-Dimensional Structured Traits

(2017) Xiang Zhan et al.   GENETICS

Powerful Genetic Association Analysis for Common or Rare Variants with High-Dimensional Structured Traits

(2017) Xiang Zhan et al.   GENETICS

A Statistical Approach for Testing Cross-Phenotype Effects of Rare Variants

(2016) K. Alaine Broadaway et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A method for analyzing multiple continuous phenotypes in rare variant association studies allowing for flexible correlations in variant effects

(2016) Jianping Sun et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A comparison study of multivariate fixed models and Gene Association with Multiple Traits (GAMuT) for next-generation sequencing

(2016) Chi-Yang Chiu et al.   GENETIC EPIDEMIOLOGY

Rare variant association test with multiple phenotypes

(2016) Selyeong Lee et al.   GENETIC EPIDEMIOLOGY

Sequence Kernel Association Test of Multiple Continuous Phenotypes

(2016) Baolin Wu et al.   GENETIC EPIDEMIOLOGY

A multiple-phenotype imputation method for genetic studies

(2016) Andrew Dahl et al.   NATURE GENETICS

USAT: A Unified Score-Based Association Test for Multiple Phenotype-Genotype Analysis

(2015) Debashree Ray et al.   GENETIC EPIDEMIOLOGY

Pleiotropy Analysis of Quantitative Traits at Gene Level by Multivariate Functional Linear Models

(2015) Yifan Wang et al.   GENETIC EPIDEMIOLOGY

Associating Multivariate Quantitative Phenotypes with Genetic Variants in Family Samples with a Novel Kernel Machine Regression Method

(2015) Q. Yan et al.   GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Rare variant testing across methods and thresholds using the multi-kernel sequence kernel association test (MK-SKAT)

(2015) Eugene Urrutia et al.   Statistics and Its Interface

Maximizing the Power of Principal-Component Analysis of Correlated Phenotypes in Genome-wide Association Studies

(2014) Hugues Aschard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rare-Variant Association Analysis: Study Designs and Statistical Tests

(2014) Seunggeung Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Efficient multivariate linear mixed model algorithms for genome-wide association studies

(2014) Xiang Zhou et al.   NATURE METHODS

Identification of Rare Causal Variants in Sequence-Based Studies: Methods and Applications to VPS13B, a Gene Involved in Cohen Syndrome and Autism

(2014) Iuliana Ionita-Laza et al.   PLoS Genetics

Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes

(2013) W. Xie et al.   DIABETES

Kernel Machine SNP-Set Testing Under Multiple Candidate Kernels

(2013) Michael C. Wu et al.   GENETIC EPIDEMIOLOGY

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

The advantages and limitations of trait analysis with GWAS: a review

(2013) Arthur Korte et al.   Plant Methods

Branched-chain amino acids in liver diseases

(2013) Kazuto Tajiri   WORLD JOURNAL OF GASTROENTEROLOGY

Polygenic Modeling with Bayesian Sparse Linear Mixed Models

(2013) Xiang Zhou et al.   PLoS Genetics

Optimal Unified Approach for Rare-Variant Association Testing with Application to Small-Sample Case-Control Whole-Exome Sequencing Studies

(2012) Seunggeun Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Optimal tests for rare variant effects in sequencing association studies

(2012) S. Lee et al.   BIOSTATISTICS

Metabolic Signatures of Insulin Resistance in 7,098 Young Adults

(2012) P. Wurtz et al.   DIABETES

Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men

(2012) A. Stancakova et al.   DIABETES

Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults

(2012) P. Wurtz et al.   DIABETES CARE

PSEA: Phenotype Set Enrichment Analysis-A New Method for Analysis of Multiple Phenotypes

(2012) Janina S. Ried et al.   GENETIC EPIDEMIOLOGY

Multivariate Phenotype Association Analysis by Marker-Set Kernel Machine Regression

(2012) Arnab Maity et al.   GENETIC EPIDEMIOLOGY

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

(2012) Jeroen R Huyghe et al.   NATURE GENETICS

Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

(2011) Michael C. Wu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Abundant Pleiotropy in Human Complex Diseases and Traits

(2011) Shanya Sivakumaran et al.   AMERICAN JOURNAL OF HUMAN GENETICS

PRIMe: a method for characterization and evaluation of pleiotropic regions from multiple genome-wide association studies

(2011) Jie Huang et al.   BIOINFORMATICS

Pervasive Sharing of Genetic Effects in Autoimmune Disease

(2011) Chris Cotsapas et al.   PLoS Genetics

Robust relationship inference in genome-wide association studies

(2010) Ani Manichaikul et al.   BIOINFORMATICS

Pediatric Endocrinology and Inborn Errors of Metabolism

(2009)   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

A multivariate test of association

(2008) Manuel A. R. Ferreira et al.   BIOINFORMATICS