Article
Biochemistry & Molecular Biology
Ochuko L. Erukainure, Veronica F. Salau, Xin Xiao, Motlalepula G. Matsabisa, Neil A. Koorbanally, Md Shahidul Islam
Summary: The study investigated the antidiabetic mechanism of Chrysophyllum albidum infusion by studying its effects on glucose uptake and modulation of metabolic activities. The infusion was found to improve glucose uptake in muscle and modulate various key metabolic activities related to diabetes. LC-MS analysis revealed the presence of phenolics in the infusion.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Shi-Hai Yan, Li-Mu Hu, Xue-Hui Hao, Jiang Liu, Xi-Ying Tan, Zhi-Rong Geng, Jing Ma, Zhi-Lin Wang
Summary: This study revealed the direct binding target protein of berberine in colorectal cancer cells, which is pyruvate kinase isozyme type M2 (PKM2). Berberine inhibits the progression of colorectal cancer through hydrophobic interaction and pi-pi interaction, and it also inhibits the reprogramming of glucose metabolism.
Review
Biochemistry & Molecular Biology
Jie Gao, Qiaoban Wang, Yan-Dong Tang, Jingbo Zhai, Wei Hu, Chunfu Zheng
Summary: Apoptosis, necrosis, and autophagy are different strategies used by host cells to defend against pathogens such as viruses, bacteria, or fungi. Ferroptosis is a newly discovered regulated cell death that pathogens can manipulate to promote their replication and pathogenesis. However, the interaction between ferroptosis and pathogenic infections is still not fully understood. This review summarizes the advances in understanding how pathogens exploit and regulate ferroptosis and discusses potential therapeutic approaches against pathogen-associated diseases.
TRENDS IN MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Kai Wang, Stephen H. H. Smith, Hirotaka Iijima, Zachary R. R. Hettinger, Adarsh Mallepally, Sanjeev G. G. Shroff, Fabrisia Ambrosio
Summary: Understanding the cell-autonomous changes in skeletal muscle during aging, regeneration, and intervention is crucial for improving functional recovery in the elderly. However, traditional biological aging models have limitations. To overcome these limitations, a 3D muscle aging system was created and it was found that old muscle constructs (OMC) exhibit a sarcopenic phenotype and impaired regenerative capacity. Enhanced expression of complement component 4b (C4b) in aging muscle was identified as a contributing factor to impaired muscle regeneration, but inhibition of C4b improved regeneration in vitro and in vivo, suggesting a novel approach to enhance aged muscle repair.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Jiawei Wu, Ai Egusa, Toshihide Nishimura
Summary: Carnosine and anserine are abundant peptides in vertebrate skeletal muscle and nervous system. Exogenous carnosine improves exercise performance and acts as an antioxidant and antifatigue supplement. This study investigated the physiological roles of endogenous carnosine by analyzing carnosine synthase gene-deficient mice. The findings suggest that carnosine deficiency affects weight maintenance and protein metabolism in skeletal muscle.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Jiazhi Yi, Shuyun Wu, Siwei Tan, Yunfei Qin, Xing Wang, Jie Jiang, Huiling Liu, Bin Wu
Summary: The study found that BBR can alleviate mouse liver fibrosis and restore liver function, but Fer-1 treatment significantly diminishes the pharmacological effects of BBR. BBR induces HSC ferroptosis by affecting the autophagy-lysosome pathway and increasing ROS production in HSCs, thereby slowing down the progression of liver fibrosis.
CELL DEATH DISCOVERY
(2021)
Article
Geriatrics & Gerontology
Francesca M. Alves, Kai Kysenius, Marissa K. Caldow, Justin P. Hardee, Jin D. Chung, Jennifer Trieu, Dominic J. Hare, Peter J. Crouch, Scott Ayton, Ashley Bush, Gordon S. Lynch, Rene Koopman
Summary: Muscle tissues from dystrophic mice showed increased iron levels and dysregulated iron-related proteins associated with the pathology. Muscle iron levels were manipulated by iron chelation and iron-enriched feed, with chelation reducing fibrosis and reactive oxygen species but suppressing certain proteins, while iron supplementation increased specific proteins without altering other aspects of pathology.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Physiology
Mahdi Ahsan, Lea Garneau, Celine Aguer
Summary: Myokines are peptides and proteins secreted by skeletal muscle cells, which can influence energy metabolism via AMPK signalling. Understanding how Myokines affect AMPK signalling and their mutual influence is important for better elucidation of metabolic regulation during exercise and at rest. This review covers the latest research on the relationship between AMPK signalling and Myokines within skeletal muscles.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Debora Santos Rocha, Maiza Von Dentz, Jorge Felipe Argenta Model, Everton Lopes Vogt, Renata Ohlweiler, Matheus Vieira Lima, Samir Khal de Souza, Luiz Carlos Kucharski
Summary: This study investigates the peculiarities of glucose metabolism in female rats subjected to two classic experimental diabetes protocols. The results show that high dosage of single streptozotocin leads to lower glycogen levels in the liver and muscle, while low dosage of streptozotocin reduces lipid synthesis in the liver. After 30 days, diabetic animals have higher blood glucose levels but no decrease in insulin levels, no effects on muscle glucose uptake, and no increase in hepatic gluconeogenesis.
BIOMEDICAL JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Lenka Jourova, Stefan Satka, Veronika Frybortova, Iveta Zapletalova, Pavel Anzenbacher, Eva Anzenbacherova, Petra Petr Hermanova, Barbora Drabonova, Dagmar Srutkova, Hana Kozakova, Tomas Hudcovic
Summary: This study demonstrates that pretreatment with butyrate can alleviate colonic inflammation and affect hepatic drug metabolism enzyme activity in mice, highlighting the importance of investigating the gut-liver axis in inflammatory bowel disease and microbiome-targeted interventions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Physiology
Jacob Frandsen, Ronni Eg Sahl, Tue Romer, Mikkel Thunestvedt Hansen, Andreas Blaaholm Nielsen, Michelle Munk Lie-Olesen, Hanne Kruuse Rasmusen, Ditte Sogaard, Arthur Ingersen, Mads Rosenkilde, Klaas Westerterp, Jens Juul Holst, Jesper Lovind Andersen, Adam Roman Markowski, Agnieszka Blachnio-Zabielska, Christoffer Clemmensen, Massimo Sacchetti, Angelo Cataldo, Marcello Traina, Steen Larsen, Flemming Dela, Jorn Wulff Helge
Summary: This study compared the metabolic and physiological changes in younger and older men after extreme endurance exercise. The results indicated that older individuals experienced a negative adaptive response in cardiovascular function, while both younger and older men showed a positive response in peripheral tissues.
Article
Pharmacology & Pharmacy
Lenka Jourova, Stefan Satka, Veronika Frybortova, Iveta Zapletalova, Pavel Anzenbacher, Eva Anzenbacherova, Petra Petr Hermanova, Barbora Drabonova, Dagmar Srutkova, Hana Kozakova, Tomas Hudcovic
Summary: The development of inflammatory bowel disease (IBD) is closely related to changes in the gut microbiota. Butyrate, a gut microbiome-derived metabolite with anti-inflammatory effects, shows promise as a potential treatment option for IBD. This study aimed to investigate the protective effects of sodium butyrate (SB) administration on colonic inflammation and its effects on hepatic drug metabolism. The results revealed that butyrate pre-treatment can alleviate gut inflammation and improve the integrity of the colonic epithelium in mice with induced colitis. Additionally, butyrate was found to affect the expression and enzyme activity of certain cytochromes P450 (CYPs) in the liver. These findings highlight the importance of understanding the impact of gut inflammation and therapeutic interventions on drug metabolism in the context of IBD therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Jun Chen, Ruilan Du, Chunyan Huang, Lihong Jia, Defu Tie, Zhaohui Fan, Chuting Zhou, Qizhu Chen, Huaben Bo
Summary: This study found that gut microbiota such as Bacteroides affect the efficacy of DBT by influencing the metabolism and absorption of DBT active ingredients such as caffeic acid and formononetin. The use of antibiotics led to a significant decrease in the drug metabolic pathway of gut microbiota, further weakening the efficacy of DBT.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biology
Daniela Gabbia, Marco Roverso, Samantha Sarcognato, Ilaria Zanotto, Nicola Ferri, Francesco Paolo Russo, Maria Guido, Sara Bogialli, Sara De Martin
Summary: This study evaluated the effect of liver steatosis on the metabolism of sofosbuvir, a direct antiviral agent used to treat hepatitis C. The results showed that plasma levels of the inactive metabolite GS-331007 increased significantly in rats with steatosis, while the expression of the enzyme UMP-CMPK, responsible for activating sofosbuvir, was significantly lower. This may explain the reduced efficacy of sofosbuvir in patients with liver steatosis.
Article
Pharmacology & Pharmacy
Seiya Takemoto, Masataka Nakano, Tatsuki Fukami, Miki Nakajima
Summary: The study reveals that m(6)A modification negatively regulates CES2 expression by impacting its protein level, hydrolase activity, and lipid accumulation, thereby affecting pharmacokinetics and lipid metabolism. The regulation of CES2 by m(6)A modification highlights the potential significance of epitranscriptomic modifications in drug response and metabolic processes.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Zhan Ye, Chen Cao, Yuanfa Liu, Peirang Cao, Qiu Li
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2018)
Article
Chemistry, Applied
Pei Cao, Da-Wei Chen, Jiang Liang, Ping-Gu Wu, Sheng Wen, Jing Wei, Si-Jie Liu, Xi-Mei Wu, Yun-Feng Zhao, Hai-Bin Xu
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2019)
Article
Chemistry, Applied
Pei Cao, Ai-Dong Liu, Da-Jin Yang, Jiang Liang, Xiao-Dan Wang, Hai-Bin Xu, Ning Ma
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2019)
Article
Food Science & Technology
Jiang Liang, Xuxia Liang, Pei Cao, Xiaodan Wang, Peng Gao, Ning Ma, Ning Li, Haibin Xu
JOURNAL OF FOOD SCIENCE
(2019)
Article
Food Science & Technology
Wuliang Wang, Xiaoyu Yang, Zhan Ye, Youdong Li, Yuanfa Liu, Peirang Cao
JOURNAL OF FOOD SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Jingjie Ju, Zhaojun Zheng, Yong-jiang Xu, Peirang Cao, Jingwei Li, Qiu Li, Yuanfa Liu
LIPIDS IN HEALTH AND DISEASE
(2019)
Article
Chemistry, Applied
Jiang Liang, Pei Cao, Xiaodan Wang, Peng Gao, Haibin Xu, Ning Ma
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2019)
Article
Chemistry, Applied
Zhan Ye, Ruizhi Li, Chen Cao, Yong-Jiang Xu, Peirang Cao, Qiu Li, Yuanfa Liu
Article
Chemistry, Applied
Hongjian Chen, Yong Wang, Peirang Cao, Yuanfa Liu
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2019)
Article
Public, Environmental & Occupational Health
Weifeng Mao, Yan Song, Haixia Sui, Pei Cao, Zhaoping Liu
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
(2019)
Article
Environmental Sciences
Xiaodan Wang, Jiang Liang, Pei Cao, Shuang Zhou, Aibo Wu, Peng Gao, Haibin Xu, Zhaoping Liu, Yunyun Gong
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Article
Biochemistry & Molecular Biology
Youdong Li, Liang Zhang, Yong-Jiang Xu, Jinwei Li, Peirang Cao, Yuanfa Liu
Correction
Biochemistry & Molecular Biology
Zhan Ye, Chen Cao, Ruizhi Li, Peirang Cao, Qiu Li, Yuanfa Liu
Article
Biochemistry & Molecular Biology
Zhan Ye, Chen Cao, Ruizhi Li, Peirang Cao, Qiu Li, Yuanfa Liu
Letter
Environmental Sciences
Wang Hua Li, Ding Hao, Cao Pei, Zhang Jian Bo, Wu Di, Tian Jing
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2019)