Disruption of MET Receptor Tyrosine Kinase, an Autism Risk Factor, Impairs Developmental Synaptic Plasticity in the Hippocampus

The autism-associated MET receptor tyrosine kinase engages early neuronal growth mechanism and controls glutamatergic circuits development in the forebrain

(2016) Y Peng et al.   MOLECULAR PSYCHIATRY

Complete or partial reduction of the Met receptor tyrosine kinase in distinct circuits differentially impacts mouse behavior

(2015) Barbara L. Thompson et al.   Journal of Neurodevelopmental Disorders

MET Receptor Tyrosine Kinase Controls Dendritic Complexity, Spine Morphogenesis, and Glutamatergic Synapse Maturation in the Hippocampus

(2014) Shenfeng Qiu et al.   JOURNAL OF NEUROSCIENCE

Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

(2014) Miquel Bosch et al.   NEURON

Dendrite morphogenesis depends on relative levels of NT-3/TrkC signaling

(2014) W. Joo et al.   SCIENCE

A novel computational biostatistics approach implies impaired dephosphorylation of growth factor receptors as associated with severity of autism

(2014) K M Wittkowski et al.   Translational Psychiatry

Integrative Functional Genomic Analyses Implicate Specific Molecular Pathways and Circuits in Autism

(2013) Neelroop N. Parikshak et al.   CELL

Prenatal Expression of MET Receptor Tyrosine Kinase in the Fetal Mouse Dorsal Raphe Nuclei and the Visceral Motor/Sensory Brainstem

(2013) Hsiao-Huei Wu et al.   DEVELOPMENTAL NEUROSCIENCE

Synaptic and extrasynaptic location of the receptor tyrosine kinase met during postnatal development in the mouse neocortex and hippocampus

(2013) Kathie L. Eagleson et al.   JOURNAL OF COMPARATIVE NEUROLOGY

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity

(2013) O. A. Shipton et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome

(2013) J T Plummer et al.   Translational Psychiatry

Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses

(2012) James P. Clement et al.   CELL

Synaptic plasticity of NMDA receptors: mechanisms and functional implications

(2012) David L Hunt et al.   CURRENT OPINION IN NEUROBIOLOGY

Neurotrophin regulation of neural circuit development and function

(2012) Hyungju Park et al.   NATURE REVIEWS NEUROSCIENCE

Autism-Associated Promoter Variant in MET Impacts Functional and Structural Brain Networks

(2012) Jeffrey D. Rudie et al.   NEURON

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

(2012) H. Y. Zoghbi et al.   Cold Spring Harbor Perspectives in Biology

Autism genetics: searching for specificity and convergence

(2012) Jamee M Berg et al.   GENOME BIOLOGY

Structural plasticity of dendritic spines

(2011) Miquel Bosch et al.   CURRENT OPINION IN NEUROBIOLOGY

A new synaptic player leading to autism risk: Met receptor tyrosine kinase

(2011) Matthew C. Judson et al.   Journal of Neurodevelopmental Disorders

Circuit-Specific Intracortical Hyperconnectivity in Mice with Deletion of the Autism-Associated Met Receptor Tyrosine Kinase

(2011) S. Qiu et al.   JOURNAL OF NEUROSCIENCE

Regulation of MET by FOXP2, Genes Implicated in Higher Cognitive Dysfunction and Autism Risk

(2011) Z. Mukamel et al.   JOURNAL OF NEUROSCIENCE

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

AMPA receptor regulation during synaptic plasticity in hippocampus and neocortex

(2011) Hey-Kyoung Lee et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Conserved Subcortical and Divergent Cortical Expression of Proteins Encoded by Orthologs of the Autism Risk Gene MET

(2010) Matthew C. Judson et al.   CEREBRAL CORTEX

Evidence of cell-nonautonomous changes in dendrite and dendritic spine morphology in the met-signaling-deficient mouse forebrain

(2010) Matthew C. Judson et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Further evidence for the role of MET in autism susceptibility

(2010) Ismail Thanseem et al.   NEUROSCIENCE RESEARCH

Further evidence that the rs1858830 C variant in the promoter region of theMETgene is associated with autistic disorder

(2009) Pamela B. Jackson et al.   Autism Research

The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders

(2009) Pat Levitt et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain

(2009) Matthew C. Judson et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Synaptic Circuit Abnormalities of Motor-Frontal Layer 2/3 Pyramidal Neurons in an RNA Interference Model of Methyl-CpG-Binding Protein 2 Deficiency

(2009) L. Wood et al.   JOURNAL OF NEUROSCIENCE

Human-specific transcriptional regulation of CNS development genes by FOXP2

(2009) Genevieve Konopka et al.   NATURE

MET and autism susceptibility: family and case–control studies

(2008) Inês Sousa et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Neuroligins and neurexins link synaptic function to cognitive disease

(2008) Thomas C. Südhof   NATURE

Hepatocyte growth factor and c-Met promote dendritic maturation during hippocampal neuron differentiation via the Akt pathway

(2007) Chol Seung Lim et al.   CELLULAR SIGNALLING