Current Treatment Strategies and Future Treatment Options for Dravet Syndrome

Treatment Strategies for Dravet Syndrome

(2018) Kelly G. Knupp et al.   CNS DRUGS

Antiepileptic Drugs in Clinical Development: Differentiate or Die?

(2018) Gaetano Zaccara et al.   CURRENT PHARMACEUTICAL DESIGN

Stiripentol efficacy and safety in Dravet syndrome: a 12-year observational study

(2018) Kenneth A Myers et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Influence of contraindicated medication use on cognitive outcome in Dravet syndrome and age at first afebrile seizure as a clinical predictor in SCN1A -related seizure phenotypes

(2018) Iris M. de Lange et al.   EPILEPSIA

Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center

(2018) Giulia S. Porcari et al.   EPILEPSY & BEHAVIOR

Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial

(2018) Elizabeth A Thiele et al.   LANCET

Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome

(2018) Orrin Devinsky et al.   NEUROLOGY

Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome

(2018) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ketogenic diet effects on 52 children with pharmacoresistant epileptic encephalopathy: A clinical prospective study

(2018) Qiong Wu et al.   Brain and Behavior

Interactions between cannabidiol and commonly used antiepileptic drugs

(2017) Tyler E. Gaston et al.   EPILEPSIA

Marked efficacy of combined three-drug therapy (Sodium Valproate, Topiramate and Stiripentol) in a patient with Dravet syndrome

(2017) M. Morimoto et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

(2017) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Optimizing the Diagnosis and Management of Dravet Syndrome: Recommendations From a North American Consensus Panel

(2017) Elaine C. Wirrell et al.   PEDIATRIC NEUROLOGY

Parental Perception of Comorbidities in Children With Dravet Syndrome

(2017) Kelly G. Knupp et al.   PEDIATRIC NEUROLOGY

Growth and endocrine function in children with Dravet syndrome

(2017) Krista Eschbach et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Efficacy of adjunctive vagus nerve stimulation in patients with Dravet syndrome: A meta-analysis of 68 patients

(2017) Maxine Dibué-Adjei et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Treatment of Dravet Syndrome

(2016) Elaine C. Wirrell   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Palliative epilepsy surgery in Dravet syndrome—case series and review of the literature

(2016) Brian J. Dlouhy et al.   CHILDS NERVOUS SYSTEM

Readthrough-Promoting Drugs Gentamicin and PTC124 Fail to Rescue Na v 1.5 Function of Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes Carrying Nonsense Mutations in the Sodium Channel Gene SCN5A

(2016) Georgios Kosmidis et al.   Circulation-Arrhythmia and Electrophysiology

Five-year extended follow-up status of 10 patients with Dravet syndrome treated with fenfluramine

(2016) Berten Ceulemans et al.   EPILEPSIA

Disorders of early language development in Dravet syndrome

(2016) Daniela Chieffo et al.   EPILEPSY & BEHAVIOR

Outlining a core neuropsychological phenotype for Dravet syndrome

(2016) Domenica Battaglia et al.   EPILEPSY RESEARCH

Patients with dravet syndrome in the era of stiripentol: A French cohort cross-sectional study

(2016) Paola De Liso et al.   EPILEPSY RESEARCH

Mortality in Dravet syndrome

(2016) Monica S. Cooper et al.   EPILEPSY RESEARCH

Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures

(2016) Marcello Venzi et al.   NEUROPHARMACOLOGY

Proposing a mechanism of action for ataluren

(2016) Nadeem Siddiqui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacotherapy for Dravet Syndrome

(2016) Adam Wallace et al.   PEDIATRIC DRUGS

Pitfalls in genetic testing: the story of missedSCN1Amutations

(2016) Tania Djémié et al.   Molecular Genetics & Genomic Medicine

Seizure precipitants in Dravet syndrome: What events and activities are specifically provocative compared with other epilepsies?

(2015) Nienke E. Verbeek et al.   EPILEPSY & BEHAVIOR

Efficacy and tolerability of the ketogenic diet in Dravet syndrome – Comparison with various standard antiepileptic drug regimen

(2015) Anastasia Dressler et al.   EPILEPSY RESEARCH

Incidence of Dravet Syndrome in a US Population

(2015) Y. W. Wu et al.   PEDIATRICS

Pharmacokinetics of Clobazam and N-Desmethylclobazam in Children with Dravet Syndrome Receiving Concomitant Stiripentol and Valproic Acid

(2014) Vincent Jullien et al.   CLINICAL PHARMACOKINETICS

Role(s) of the 5-HT2C Receptor in the Development of Maximal Dentate Activation in the Hippocampus of Anesthetized Rats

(2014) Gergely Orban et al.   CNS Neuroscience & Therapeutics

Lamotrigine can be beneficial in patients with Dravet syndrome

(2014) Linda Dalic et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Dravet syndrome-From epileptic encephalopathy to channelopathy

(2014) Andreas Brunklaus et al.   EPILEPSIA

Antecollis and levodopa-responsive parkinsonism are late features of Dravet syndrome

(2014) A. Fasano et al.   NEUROLOGY

Stiripentol in Dravet syndrome: Results of a retrospective U.S. study

(2013) Elaine C. Wirrell et al.   EPILEPSIA

Encephalopathy in children with Dravet syndrome is not a pure consequence of epilepsy

(2013) Rima Nabbout et al.   Orphanet Journal of Rare Diseases

Efficacy of verapamil as an adjunctive treatment in children with drug-resistant epilepsy: A pilot study

(2013) Francesco Nicita et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment

(2013) Scott C. Baraban et al.   Nature Communications

Progressive Gait Deterioration in Adolescents With Dravet Syndrome

(2012) Jill M. Rodda et al.   ARCHIVES OF NEUROLOGY

Prognostic, clinical and demographic features in SCN1A mutation-positive Dravet syndrome

(2012) A. Brunklaus et al.   BRAIN

Dravet syndrome: Seizure control and gait in adults with different SCN1A mutations

(2012) Jennifer J. Rilstone et al.   EPILEPSIA

Successful use of fenfluramine as an add-on treatment for Dravet syndrome

(2012) Berten Ceulemans et al.   EPILEPSIA

Comorbidities and predictors of health-related quality of life in Dravet syndrome

(2011) Andreas Brunklaus et al.   EPILEPSIA

Ketogenic diet also benefits Dravet syndrome patients receiving stiripentol: A prospective pilot study

(2011) Rima Nabbout et al.   EPILEPSIA

Electroencephalographic Features in Dravet Syndrome

(2011) Nicola Specchio et al.   JOURNAL OF CHILD NEUROLOGY

A prospective open-labeled trial with levetiracetam in pediatric epilepsy syndromes: Continuous spikes and waves during sleep is definitely a target

(2011) S. Chhun et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Optogenetic Localization and Genetic Perturbation of Saccade-Generating Neurons in Zebrafish

(2010) P. J. Schoonheim et al.   JOURNAL OF NEUROSCIENCE

Addition of verapamil in the treatment of severe myoclonic epilepsy in infancy

(2009) Paola Iannetti et al.   EPILEPSY RESEARCH

Valvular regurgitation and surgery associated with fenfluramine use: an analysis of 5743 individuals

(2008) Charles F Dahl et al.   BMC Medicine