Review
Hematology
Christian M. Madsen, Anette Varbo, Borge G. Nordestgaard
Summary: Recent studies have suggested that extremely high levels of HDL cholesterol are associated with increased mortality, indicating that HDL may have harmful effects in some instances. Furthermore, observational and genetic studies have shown that HDL might be linked to the development of major noncardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Xiaohan Liu, Peiyi Luo, Weiyun Zhang, Shuxian Zhang, Shulong Yang, Fenfang Hong
Summary: Pyroptosis is a pro-inflammatory type of regulated cell death that is closely related to the formation and development of atherosclerosis. It not only causes local inflammation, but also amplifies the inflammatory response, leading to plaque instability and eventually resulting in acute cardiovascular events.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Clare MacLeod, Patrick W. F. Hadoke, Mark Nixon
Summary: Glucocorticoids play important roles in atherosclerosis, with potential athero-protective and pro-atherogenic responses. The mechanisms underlying their effects are complex and require further investigation. Understanding the regulation of glucocorticoid bioavailability in the vasculature may provide insights into their potential benefit in the treatment of cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Laura Canclini, Amir Mohammad Malvandi, Patrizia Uboldi, Najoua Jabnati, Liliana Grigore, Alberto Zambon, Andrea Baragetti, Alberico Luigi Catapano
Summary: This study aimed to investigate the interaction between PCSK9 and LDL, and found that PCSK9 interacts with a subfraction of LDL, with a binding percentage ranging from 2% to 30%, which is not correlated with plasma or LDL cholesterol levels. The association of PCSK9 with LDL appears to be sensitive to high salt concentrations. FPLC and iodixanol gradient ultracentrifugation are identified as the most suitable methods for studying this association.
Article
Hematology
Erin H. Seeley, Zhipeng Liu, Shuai Yuan, Chad Stroope, Elizabeth Cockerham, Nabil A. Rashdan, Luisa F. Delgadillo, Alexandra C. Finney, Dhananjay Kumar, Sandeep Das, Babak Razani, Wanqing Liu, James Traylor, A. Wayne Orr, Oren Rom, Christopher B. Pattillo, Arif Yurdagul Jr
Summary: Researchers used mass spectrometry imaging to characterize the spatial distribution of metabolites in stable and unstable atherosclerosis. They found that pathways related to lipid metabolism and long-chain fatty acids were enriched in stable plaques, while reactive oxygen species, aromatic amino acid, and tryptophan metabolism were increased in unstable plaques. This study provides valuable insights into the metabolic pathways involved in plaque destabilization and opens new avenues of research in cardiovascular disease.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Hematology
Charles Drummer, Fatma Saaoud, Ying Shao, Yu Sun, Keman Xu, Yifan Lu, Dong Ni, Diana Atar, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Summary: Innate immune cells can develop trained immunity after exposure to stimuli like lipopolysaccharides and oxLDL, leading to altered responses upon subsequent challenges. This phenomenon is important for host defense and inflammation, particularly in cardiovascular and metabolic diseases. Trained immunity involves rewiring cellular metabolism and epigenetic remodeling that enhance gene transcription and proinflammatory immune responses, contributing to chronic inflammation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Hematology
George E. G. Kluck, Alexander S. Qian, Emmanuel H. Sakarya, Henry Quach, Yak D. Deng, Bernardo L. Trigatti
Summary: Atherosclerosis is a chronic disease that affects the artery wall and is a major contributor to cardiovascular diseases. Necrotic cores, which contain debris from dead macrophages, increase the risk of plaque rupture and thrombus formation. HDL (high-density lipoprotein) has direct protective effects on different cells within atherosclerotic plaques, but its role in protecting against necroptosis and necrotic core formation is not fully understood.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Rheumatology
Philipp Jud, Franz Hafner, Andreas Meinitzer, Marianne Brodmann, Christian Dejaco, Guenther Silbernagel
Summary: This study evaluated endothelial dysfunction, lipid metabolism, and the prevalence and development of cardiovascular diseases in patients with giant cell arteritis (GCA). GCA patients had a higher prevalence of arterial disease and higher levels of cholesterol, lipoproteins, and triglycerides. They also had a higher risk of cardiovascular events, with underuse of statins and elevated LDL cholesterol concentrations.
Article
Rheumatology
Anne Grete Semb, Silvia Rollefstad, Eirik Ikdahl, Grunde Wibetoe, Joseph Sexton, Cindy Crowson, Piet van Riel, George Kitas, Ian Graham, Solbritt Rantapaa-Dahlqvist, George Athanasios Karpouzas, Elena Myasoedova, Miguel A. Gonzalez-Gay, Petros P. Sfikakis, Maria G. Tektonidou, Argyro Lazarini, Dimitrios Vassilopoulos, Bindee Kuriya, Carol Hitchon, Maria Simona Stoenoiu, Patrick Durez, Virginia Pascual-Ramos, Dionicio Angel Galarza-Delgado, Pompilio Faggiano, Durga Prasanna Misra, Andrew A. Borg, Rong Mu, Erkin M. Mirrakhimov, Diane Gheta, Karen Douglas, Vikas Agarwal, Svetlana Myasoedova, Lev Krougly, Tatiana Valentinovna Popkova, Alena Tuchynova, Michal Tomcik, Michal Vrablik, Jiri Lastuvka, Pavel Horak, Helena Kaspar Medkova, Anne M. Kerola
Summary: The prevalence of ASCVD was higher in RA-DM compared to RAwoDM, and lipid goals were more frequently obtained in RA-DM. Lessons from CVD prevention programs in diabetes mellitus could benefit patients with rheumatoid arthritis.
Article
Rheumatology
George C. Drosos, George Konstantonis, Petros P. Sfikakis, Maria G. Tektonidou
Summary: This study examined the eligibility for blood pressure and lipid treatment in patients with antiphospholipid syndrome (APS) according to the recommendations of the European Alliance of Associations for Rheumatology (EULAR) and the European Society of Cardiology (ESC). Different risk classifiers were used to calculate predicted cardiovascular risk, and actual cardiovascular risk was determined based on ESC guidelines. The results showed that multimodal risk assessment, including disease-related and cardiometabolic features, can improve cardiovascular risk management in APS.
Review
Hematology
Ashish Misra, Rajan Rehan, Alexander Lin, Sanjay Patel, Edward A. Fisher
Summary: Clonal expansion plays a crucial role in atherosclerosis, particularly in smooth muscle cells and macrophages. Recent studies have revealed the contribution of clonal expansion to disease pathology and provided innovative directions for future therapies of atherosclerosis and associated cardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Hematology
Pierre R. Moreau, Vanesa Tomas Bosch, Maria Bouvy-Liivrand, Kadri Ounap, Tiit Ord, Heidi H. Pulkkinen, Petri Polonen, Merja Heinaniemi, Seppo Yla-Herttuala, Johanna P. Laakkonen, Suvi Linna-Kuosmanen, Minna U. Kaikkonen
Summary: This study aimed to characterize microRNA-related regulatory mechanisms in the aorta during atherosclerosis. The research analyzed miRNA expression changes in different cell types under proatherogenic stimuli and found common miRNA species dominating in all cell types. The study identified potential mechanisms by which miRNAs affect atherogenesis in a cell-type-specific manner.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Amanda C. Doran
Summary: This article discusses the major failures of resolution in atherosclerosis and explores new potential regulators that are of translational significance.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Marco Orecchioni, Dennis Wolf, Vasantika Suryawanshi, Holger Winkels, Kouji Kobiyama, Jeffrey Makings, William B. Kiosses, Klaus Ley
Summary: Atherosclerosis is caused by the retention of lipoproteins and cholesterol in the subendothelial layer, leading to an inflammatory process and plaque formation. Macrophages are found to be the main producers of the anti-inflammatory cytokine IL-10 in atherosclerotic plaques. IL-10 secretion by macrophages is critical for limiting atherosclerosis progression.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Xiao-Chang Liu, Ping-Kun Zhou
Summary: The long-term survival rate of cancer patients has increased, leading to an increase in non-cancer diseases such as cardiovascular disease. There is a strong association between the development of cardiovascular disease in long-term cancer survivors and radiation exposure. The development of radiation-induced cardiovascular diseases is a complex process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Fang Li, Hanrui Zhang
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Huize Pan, Chenyi Xue, Benjamin J. Auerbach, Jiaxin Fan, Alexander C. Bashore, Jian Cui, Dina Y. Yang, Sarah B. Trignano, Wen Liu, Jianting Shi, Chinyere O. Ihuegbu, Erin C. Bush, Jeremy Worley, Lukas Vlahos, Pasquale Laise, Robert A. Solomon, Edward S. Connolly, Andrea Califano, Peter A. Sims, Hanrui Zhang, Mingyao Li, Muredach P. Reilly
Editorial Material
Hematology
Clint L. Miller, Hanrui Zhang
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Canan Kasikara, Maaike Schilperoort, Brennan Gerlach, Chenyi Xue, Xiaobo Wang, Ze Zheng, George Kuriakose, Bernhard Dorweiler, Hanrui Zhang, Gabrielle Fredman, Danish Saleheen, Muredach P. Reilly, Ira Tabas
Summary: The rs9349379-G allele is associated with lower levels of PHACTR1 and impaired efferocytosis in macrophages, potentially contributing to CAD risk by compromising the clearance of apoptotic cells in atherosclerotic lesions.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Editorial Material
Hematology
Hanrui Zhang, Zhen Bouman Chen, Gabrielle Fredman, Delphine Gomez, Isabella M. Grumbach, Ngan F. Huang, Patricia Kim Phuong Nguyen, Mireille Ouimet, Nadia R. Sutton, Elena Aikawa
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Editorial Material
Hematology
Hanrui Zhang, Dennis Wolf
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Leroy C. Joseph, Jianting Shi, Quynh N. Nguyen, Victoria Pensiero, Chris Goulbourne, Robert C. Bauer, Hanrui Zhang, John P. Morrow
Summary: This study examines the response of the heart to a high-fat diet at the metabolomic and transcriptomic levels, revealing significant sex differences in cardiac metabolites and gene expression.
Article
Cardiac & Cardiovascular Systems
Jian Cui, Sewon Lee, Yan Sun, Cuihua Zhang, Michael A. Hill, Yuhang Li, Hanrui Zhang
Summary: Intermittent fasting, particularly ADF, has clinically significant metabolic benefits and can protect against diabetes-associated endothelial dysfunction by modulating adiponectin levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Hematology
Mabruka Alfaidi, Hanrui Zhang, Suellen D. Oliveira
Summary: The COVID-19 pandemic has led to a race in the scientific community to develop new vaccines and treatment options, as well as the development of innovative communication strategies through audiovisual platforms and social media. New roles have emerged in the scientific community, with a recognition of the need to support new forms of communication to advance science.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Hematology
Xin Bi, Sylvia Stankov, Paul C. Lee, Ziyi Wang, Xun Wu, Li Li, Yi-An Ko, Lan Cheng, Hanrui Zhang, Nicholas J. Hand, Daniel J. Rader
Summary: ILRUN is an important regulator of lipoprotein metabolism in mice and plays a role in the development of atherosclerosis. It affects atherosclerosis through both plasma lipid-dependent and lipid-independent mechanisms. These findings provide new insights into the pathogenesis of coronary artery disease.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Hematology
Esther Cynn, Daniel Y. Li, Marcella E. O'Reilly, Ying Wang, Alexander C. Bashore, Anjali Jha, Andrea S. Foulkes, Hanrui Zhang, Hanna Winter, Lars Maegdefessel, Hanying Yan, Mingyao Li, Leila Ross, Chenyi Xue, Muredach P. Reilly
Summary: In this study, researchers identified a non-conserved, human-specific long noncoding RNA called SIMALR that suppresses macrophage apoptosis in atherosclerosis. SIMALR interacts with HIF1α to regulate the transcription of a known macrophage survival factor, NTN1. This research highlights the importance of investigating the functions of human lncRNAs and exploring their translational and therapeutic potential in atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Fang Li, Hanrui Zhang
CIRCULATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Jianting Shi, Xun Wu, Ziyi Wang, Fang Li, Yujiao Meng, Rebecca M. Moore, Jian Cui, Chenyi Xue, Katherine R. Croce, Arif Yurdagul, John G. Doench, Wei Li, Konstantinos S. Zarbalis, Ira Tabas, Ai Yamamoto, Hanrui Zhang
Summary: This study identified WDFY3 as a novel regulator of efferocytosis through a genome-wide CRISPR screen, revealing its role in promoting LC3 lipidation and lysosomal acidification for the degradation of apoptotic cell components.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Hanrui Zhang, Benedek Halmos, Marit Westerterp
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Mualla Ozcan, Xuewei Zhu, Hanrui Zhang, Ali Javaheri
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
