The peculiar genetics of the ribosomal DNA blurs the boundaries of transgenerational epigenetic inheritance

New Roles for the Nucleolus in Health and Disease

(2018) Lorena Núñez Villacís et al.   BIOESSAYS

Early life diet conditions the molecular response to post-weaning protein restriction in the mouse

(2018) Amy F. Danson et al.   BMC BIOLOGY

The EGF/Ras pathway controls growth in Drosophila via ribosomal RNA synthesis

(2018) Shrivani Sriskanthadevan-Pirahas et al.   DEVELOPMENTAL BIOLOGY

The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability

(2018) Silvana Paredes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies

(2018) Wenyan Sun et al.   NATURE NEUROSCIENCE

Variation in human chromosome 21 ribosomal RNA genes characterized by TAR cloning and long-read sequencing

(2018) Jung-Hyun Kim et al.   NUCLEIC ACIDS RESEARCH

Identification of a novel TIF-IA–NF-κB nucleolar stress response pathway

(2018) Jingyu Chen et al.   NUCLEIC ACIDS RESEARCH

Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis

(2018) Mikael S. Lindström et al.   ONCOGENE

Impact of sampling strategies and reconstruction protocols in nasal airflow simulations in fossil hominins

(2018) Andrej A. Evteev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleolar Function in Lifespan Regulation

(2018) Varnesh Tiku et al.   TRENDS IN CELL BIOLOGY

Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells

(2018) Kevin L Lu et al.   eLife

Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression

(2018) Matthew M. Parks et al.   Science Advances

The use of cytopathology to identify disturbances in oral squamous cell carcinoma at early stage: A case report

(2018) Natália Batista Daroit et al.   DIAGNOSTIC CYTOPATHOLOGY

Copy Number of Human Ribosomal Genes With Aging: Unchanged Mean, but Narrowed Range and Decreased Variance in Elderly Group

(2018) Elena M. Malinovskaya et al.   Frontiers in Genetics

The involvement of tau in nucleolar transcription and the stress response

(2018) Mahmoud B. Maina et al.   Acta Neuropathologica Communications

SIR2suppresses replication gaps and genome instability by balancing replication between repetitive and unique sequences

(2017) Eric J. Foss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenerational transmission of environmental information in C. elegans

(2017) Adam Klosin et al.   SCIENCE

Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington’s disease

(2017) Sarah Jesse et al.   Scientific Reports

Ribosomal DNA copy number loss and sequence variation in cancer

(2017) Baoshan Xu et al.   PLoS Genetics

DNA replication stress restricts ribosomal DNA copy number

(2017) Devika Salim et al.   PLoS Genetics

Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast

(2017) Joseph C. Sanchez et al.   PLoS Genetics

Ribosomal DNA copy number amplification and loss in human cancers is linked to tumor genetic context, nucleolus activity, and proliferation

(2017) Meng Wang et al.   PLoS Genetics

Nucleolar Proteome Analysis and Proteasomal Activity Assays Reveal a Link between Nucleolus and 26S Proteasome in A. thaliana

(2017) Charlotte Montacié et al.   Frontiers in Plant Science

Small nucleoli are a cellular hallmark of longevity

(2016) Varnesh Tiku et al.   Nature Communications

Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats

(2016) Daniël O. Warmerdam et al.   Cell Reports

rDNA Copy Number Variants Are Frequent Passenger Mutations in Saccharomyces cerevisiae Deletion Collections and de Novo Transformants

(2016) Elizabeth X. Kwan et al.   G3-Genes Genomes Genetics

Nutriepigenomics

(2015) Marlene Remely et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes

(2015) John G. Gibbons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenerational Inheritance of Diet-Induced Genome Rearrangements in Drosophila

(2015) John C. Aldrich et al.   PLoS Genetics

Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity

(2014) Anita Öst et al.   CELL

Transgenerational Epigenetic Inheritance: Myths and Mechanisms

(2014) Edith Heard et al.   CELL

Simple Quantitative PCR Approach to Reveal Naturally Occurring and Mutation-Induced Repetitive Sequence Variation on the Drosophila Y Chromosome

(2014) John C. Aldrich et al.   PLoS One

Ribosomal RNA gene repeats, their stability and cellular senescence

(2014) Takehiko KOBAYASHI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Changes in rRNA Transcription Influence Proliferation and Cell Fate Within a Stem Cell Lineage

(2014) Q. Zhang et al.   SCIENCE

Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development

(2013) Nisha Padmanabhan et al.   CELL

An Unexpected Link Between Notch Signaling and ROS in Restricting the Differentiation of Hematopoietic Progenitors in Drosophila

(2013) Chiyedza Small et al.   GENETICS

A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan

(2013) Elizabeth X. Kwan et al.   PLoS Genetics

Epigenetic control of RNA polymerase I transcription in mammalian cells

(2012) Ingrid Grummt et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Escherichia coli RecG functionally suppresses human Bloom syndrome phenotypes

(2012) Michael W Killen et al.   BMC MOLECULAR BIOLOGY

Nucleolar Dominance of the Y Chromosome in Drosophila melanogaster

(2012) F. Greil et al.   GENETICS

Ribosomal DNA Organization Before and After Magnification in Drosophila melanogaster

(2012) Alessio Bianciardi et al.   GENETICS

Investigations on Transgenerational Epigenetic Response Down the Male Line in F2 Pigs

(2012) Martin Braunschweig et al.   PLoS One

Transgenerational Actions of Environmental Compounds on Reproductive Disease and Identification of Epigenetic Biomarkers of Ancestral Exposures

(2012) Mohan Manikkam et al.   PLoS One

Y chromosome mediates ribosomal DNA silencing and modulates the chromatin state in Drosophila

(2012) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis

(2012) Kimberly Larson et al.   PLoS Genetics

Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change

(2011) Ki-Hyeon Seong et al.   CELL

BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription

(2011) Patrick M. Grierson et al.   HUMAN MOLECULAR GENETICS

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

(2011) Eric L. Greer et al.   NATURE

The CCCTC-Binding Factor (CTCF) of Drosophila Contributes to the Regulation of the Ribosomal DNA and Nucleolar Stability

(2011) Paola A. Guerrero et al.   PLoS One

Ribosomal DNA Deletions Modulate Genome-Wide Gene Expression: “rDNA–Sensitive” Genes and Natural Variation

(2011) Silvana Paredes et al.   PLoS Genetics

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats

(2010) Claudio Guetg et al.   EMBO JOURNAL

Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons

(2010) Valeria Specchia et al.   NATURE

CTCF regulates the local epigenetic state of ribosomal DNA repeats

(2010) Suzanne van de Nobelen et al.   Epigenetics & Chromatin

Human rRNA Gene Clusters Are Recombinational Hotspots in Cancer

(2009) D. M. Stults et al.   CANCER RESEARCH

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Expression of I-CreI Endonuclease Generates Deletions Within the rDNA of Drosophila

(2009) S. Paredes et al.   GENETICS

Ribosomal DNA contributes to global chromatin regulation

(2009) S. Paredes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epigenetics of rRNA Genes: From Molecular to Chromosome Biology

(2008) Brian McStay et al.   Annual Review of Cell and Developmental Biology

Transgenerational Epigenetic Effects

(2008) Neil A. Youngson et al.   Annual Review of Genomics and Human Genetics

A new role of the rDNA and nucleolus in the nucleus—rDNA instability maintains genome integrity

(2008) Takehiko Kobayashi   BIOESSAYS

Epigenetic regulation of heterochromatic DNA stability

(2008) Jamy C Peng et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

UBF levels determine the number of active ribosomal RNA genes in mammals

(2008) Elaine Sanij et al.   JOURNAL OF CELL BIOLOGY

Epigenetic Regulation of Retrotransposons within the Nucleolus of Drosophila

(2008) D. G. Eickbush et al.   MOLECULAR AND CELLULAR BIOLOGY

NOPdb: Nucleolar Proteome Database--2008 update

(2008) Y. Ahmad et al.   NUCLEIC ACIDS RESEARCH